Modulight news & articles

Modulight news & articles

Research Articles

Carrier-Free, Amorphous Verteporfin Nanodrug for Enhanced Photodynamic Cancer Therapy and Brain Drug Delivery

Published in: Advanced Science Authors: John A. Quinlan, Collin T. Inglut, Payal Srivastava, Idrisa Rahman, Jillian Stabile, Brandon Gaitan, Carla Arnau Del Valle, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Baktiar Karim, Nina Connolly, Robert W. Robey, Graeme F. Woodworth, Michael M. Gottesman, Huang-Chiao Huang University of Maryland Glioblastoma (GBM) is hard to treat due to cellular invasion into functioning brain tissues, limited drug delivery, and evolved treatment resistance. Recurrence is nearly universal even after surgery, chemotherapy, and radiation. Photodynamic therapy (PDT) involves photosensitizer administration followed by light activation to generate reactive oxygen species at tumor sites, thereby killing cells or Continue reading →

Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids

Published in: Cell & Bioscience Authors: Aaron Sorrin, Anika Dasgupta, Kathryn McNaughton, Carla Arnau Del Valle, Keri Zhou, Cindy Liu, Dana M. Roque & Huang Chiao Huang Within the last decade, poly(ADP-ribose) polymerase inhibitors (PARPi) have emerged in the clinic as an effective treatment for numerous malignancies. Preclinical data have demonstrated powerful combination effects of PARPi paired with photodynamic therapy (PDT), which involves light-activation of specialized dyes (photosensitizers) to stimulate cancer cell death through reactive oxygen species generation. In this study, a novel combination strategy was Continue reading →

Multiwavelength narrow linewidth laser system for Ba+ quantum computing applications

Published in: QUANTUM WEST SPIE 2024 Authors: Kostiantyn Nechay, Luukas Kuusela, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa Quantum information processing (QIP) approach based on trapped ions is a promising technology that exploits different ion species as individual qubits and qubit gates, while featuring long coherence times, high fidelity of operations, fast readout, and ion-ion gate entanglement. The practical usefulness of trapped-ion quantum computer depends on its further scaling to a large number of qubits. Meanwhile, trapped-ion quantum computer relies on a set of single-frequency lasers, utilizing Continue reading →

Narrow linewidth 650 nm DBR laser diode for quantum applications

Published in: QUANTUM WEST SPIE 2024 Authors: Riina Ulkuniemi, Luukas Kuusela, Mika Mähönen, Timo Aho, Jussi Hämelahti, Andreas Schramm, Soile Talmila, Pekko Sipilä, Petteri Uusimaa Laser systems are utilized in quantum for various applications. Multiple wavelengths and tailored solutions are required depending on the technology that the laser will be applied to. For instance, lasers can be used for controlling particles and molecules, including excitations of the quantum systems. Key performance requirements for lasers used in these applications include narrow linewidth, frequency stability, and single-frequency Continue reading →

Narrow linewidth VECSELs for Ba+ cooling at 493 nm

Published in: LASE SPIE 2024 Authors: Kostiantyn Nechay, Andreas Schramm, Mika Mähönen, Soile Talmila, Jussi Hämelahti, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa Quantum information processing based on trapped ion technology is one of the leading platforms, heavily relying on a set of single-frequency lasers in its core operations. Narrow linewidth lasers perform atom photoionization, cooling, state-preparation and read-out. In this work we demonstrate in-house designed and fabricated optically pumped semiconductor laser gain mirror comprised of InGaAs quantum wells and GaAs/AlAs distributed Bragg reflector. We demonstrate Continue reading →

Narrow linewidth 935 nm DBR laser diode for quantum applications

Published in: OPTO SPIE 2024 Authors: Mika Mähönen, Riina Ulkuniemi, Luukas Kuusela, Timo Aho, Andreas Schramm, Soile Talmila, Pekko Sipilä, Petteri Uusimaa Laser systems with ultra-stable and narrow linewidth operation are a crucial part for many quantum computing and quantum sensing technologies, such as trapped ion and neutral ion approaches. The particular interest in this work is the fabrication of a 935 nm Distributed Bragg reflector (DBR) laser which can be used to repump Yb ions permitting Doppler cooling. DBR’s can provide output powers in Continue reading →

Application notes

Photobiomodulation for pain treatment using ML6600

Customer case University of Toyama is a Japanese national university located in Toyama City and Takaoka City and established in 1949. It is comprised of 3 former national universities Toyama University, Toyama Medical and Pharmaceutical University, and Takaoka National College. Toshiaki Kume Daisuke Uta Modulight products: ML6600 Laser use: Studying pain treatment with photobiomodulation. Links to articles:     Background Photobiomodulation with low-level laser or light therapy is an effective treatment for pain. It has various effects, such as analgesic (pain-relieving) effects, anti-inflammatory effects, tissue regeneration Continue reading →

Development of thermosensitive liposomes with the help of ML8500

Customer case Pharmaceutical Nanotechnology led by Professor Timo Laaksonen on controlled drug release and delivery using modern methods and materials. Particular interest lies in using light to both monitor nanomaterial behavior and to trigger e.g. drug release processes. Modulight products: ML8500, ML6600, MLAKIT Prof. Timo Laaksonen Dr. Tatu Lajunen Laser use: Light-triggered drug release studies from light-activated liposomes. ML8500 with 808 nm wavelength was used to induce the release of calcein from liposomes under different temperatures. The effect of different type of lipids on liposomal Continue reading →

ML7710 for photoactivated treatment of lung cancer

Deadliest cancer Lung cancer is the leading cause of cancer deaths worldwide, with more than 2.2 million cases and 1.8 million deaths each year [1]. Lung cancer can be divided into two types, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), with the latter accounting for about 85% of all lung cancer cases. NSCL is usually less sensitive to chemo- and radiotherapy and in many cases tumor cannot be removed surgically or has spread from lungs to distant sites at the time Continue reading →

Distributed Bragg Reflector (DBR) Laser Diodes

Introduction to DRB lasers Distributed Bragg Reflector (DBR) laser diodes are a class of single-frequency monolithic semiconductor lasers. Monolithic semiconductor lasers in general are small in size, mechanically robust, and have good power conversion efficiency. They also provide opportunities for hybrid integration with photonic integrated circuits (PICs). This application note provides an overview of DBR lasers, their principles of operation, their modal behavior, and their diverse applications. Principles of DBR Laser Operation A DBR laser is a semiconductor laser with one or several quantum wells Continue reading →

Light-induced drug delivery with indocyanine green liposomes

Customer case Faculty of Pharmacy at University of Helsinki is specialized in top-level pharmaceutical research. Multidisciplinary research fields include clinical pharmacy, experimental drugs, nanomedicines, and pharmaceutical drug design. Drug delivery unit led by Professor Arto Urtti focuses on design and testing of advanced drug delivery systems especially for ocular indications. Light is studied as an important tool to control the drug delivery to the target tissues. Modulight products: ML6600 (810 nm) + Modulight in vitro illumination kit (MLAKIT) Professor Arto Urtti   Senior Pharmaceutical Researcher Tatu Continue reading →

Fluorescence imaging & endoscopy for tumor visualization and diagnostics

Introduction to fluorescence imaging Fluorescence is a phenomenon where substance that has absorbed certain wavelength of light emits it back at another wavelength. These substances are called fluorophores or fluorescent dyes. The emitted light has a longer wavelength than the absorbed one since some energy of the photon is lost in the process. The difference in wavelengths between absorbed and emitted light, called Stokes shift, allows very low background for fluorescence detection by separating it from the excitation light. The process of fluorescence generation is Continue reading →

Laser-Sharp Research

Modulight Spotlights: LASER-SHARP RESEARCH – March 2024

Modulight Spotlights: LASER-SHARP RESEARCH – March 2024 Glioblastoma is the most aggressive type of brain tumor. It is hard to treat because of its invasion into functioning brain tissues, limited drug delivery due to blood-brain-barrier, and evolved treatment resistance. To address these challenges, a light-activated nanoformulation, called nanoVP, was developed for glioblastoma in a new study co-led by John Quinlan and Collin Inglut in Dr. Huang’s team at the University of Maryland. Published in a prestigious journal Advanced Science, this novel therapy resulted in an improved tumor control and survival Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – February 2024

Modulight Spotlights: LASER-SHARP RESEARCH – February 2024 Photoactivated chemotherapy (PACT) is a novel anticancer therapy where cytotoxic drug is attached into a photocage, which is cleaved by light to release the drug at the tumor site. A new study led by Prof. Sylvestre Bonnet’s group at Leiden University, demonstrated a significantly improved agent for photoactivated chemotherapy. ML6600 laser was used to study the drug release from the photocage, comparing efficacy between red and green light. It was shown that the agent could be effectively released Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – January 2024

Modulight Spotlights: LASER-SHARP RESEARCH – January 2024 Phototherapy is widely established treatment for skin diseases like actinic keratosis, cutaneous infections, and skin tumors, resulting in excellent cosmetic outcomes. However, some clinically used light sensitizing drugs have drawbacks such as limited penetration depth and high painfulness to patient. In a new study by Andreea Burloiu and the teams at Carol Davila University of Medicine and Pharmacy, new photoactivated drugs were developed for treatment of skin diseases. ML6600 laser with MLAKIT was used to evaluate the effect Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – December 2023

Modulight Spotlights: LASER-SHARP RESEARCH – December 2023 Organic compounds are one of the leading causes of water pollution. Rhodamine 6G is a commonly used dye in the food and textile industries and can cause cancer when consumed in contaminated water. To tackle this problem, Professor T. Nyokong’s team at Rhodes University studied photocatalysis with ML7710 for degrading rhodamine, and showed increased degradation efficiency when photocatalysis was combined with ultrasound (sonocatalysis). This Laser-Sharp study offers a new method for more efficient degradation of organic pollutants for environmental Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – November 2023

Modulight Spotlights: LASER-SHARP RESEARCH – November 2023 The development of modern antibiotics is recognized as one of the major achievements of medicine and has saved millions of lives. However, many infectious agents have developed resistance to antibiotics over time, and defining new antibiotic targets has been difficult since very few genes are essential for pathogens. To combat this growing problem, Professor Timothy Haystead’s team at Duke University developed a novel light-based antimicrobial strategy that targets non-essential enzyme on the surface of bacteria. Light activation was Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – October 2023

Modulight Spotlights: LASER-SHARP RESEARCH – October 2023 ​Antimicrobial resistance is an increasing healthcare problem, with new effective treatment strategies urgently needed. Professor Mitsunaga and team at The Jikei University Medical School, Japan, describe a promising treatment called photoimmuno-antimicrobial strategy (PIAS) in a new Nature publication. Detailed instructions how to design and implement the treatment are given, with Modulight’s ML7710 and ML6600 series lasers validated for drug activation in the protocol. This treatment enables targeted elimination of different microbes, regardless of the species or drug resistance Continue reading →

Press releases

ISO 27001 – information security standard for Modulight

Modulight achieved the international ISO 27001 information security standard certification today on February 28, 2024. The certification of the information security management system demonstrates the organization's commitment to protecting information and managing high-level of information security. "We are expanding the use of cloud services in accordance with our SaaS business model and are making strong progress in transitioning to a pay-per-treatment (PPT) payment model. Managing patient information requires very high-level information security processes, which is why we started to pursue the ISO 27001 certification in Continue reading →

Modulight Announces Involvement in GlioLighT Project for Glioma Treatment

Modulight is pleased to announce its participation in the GlioLighT project, aimed at developing new treatment options for gliomas. This project has received substantial funding of approximately EUR 2.2 million over three years from the European Innovation Council's Pathfinder program. The GlioLighT project partners include Johannes Gutenberg University Mainz, Aston University in Birmingham, the University of Barcelona, LMU Munich, and MODUS Research and Innovation Ltd. The budgetary allotment of the project for Modulight is about EUR 400,000 over the duration of the project. Gliomas, known Continue reading →

Modulight Forges Strategic Partnership with Laser 2000 UK for Market Expansion in the UK and Ireland

Modulight is pleased to announce a sales partnership with Laser 2000 UK Ltd, a renowned reseller of laser-based solutions in the UK and Ireland. The partnership marks a significant step in expanding Modulight's presence in the UK and Irish markets, leveraging Laser 2000 UK's established customer base, broad sales team, and technical expertise. Under this collaboration, Laser 2000 UK will integrate Modulight's cutting-edge laser technologies into their diverse range of photonics solutions. This synergy is expected to enrich Laser 2000 UK's system solutions offering, particularly Continue reading →

Modulight launches ML6600 for Flow Cytometry and Quantum Computing

Next week at Photonics West 2024, Modulight will unveil significant new additions to the ML6600 laser solution platform. These new innovations include a specialized laser engine tailored for Flow Cytometry applications, and advanced DBR laser cores designed specifically for the Quantum Computing market. Our #LaserFamily are presenting 11 conference papers plus participating in a technical panel, across the Photonics West conferences BIOS, OPTO, LASE and QUANTUM WEST. You can see the list here. ML6600 for Flow Cytometry – Laser engine with active beam steering The newest product utilizing the ML6600 platform is a specialized laser engine for the Continue reading →

Pioneering study confirms benefits of Modulight’s technology and photoimmunotherapy for ovarian cancer

A study published in Science Advances has for the first time scientifically demonstrated the potential of fluorescence-guided photoimmunotherapy enabled with Modulight's laser platform and cloud technology. The study, a collaboration between the University of Maryland (UMD) and Modulight, confirms the benefits of targeted nanomedicine, Modulight’s medical laser system, and fluorescence-guided intervention in both achieving better treatment outcomes and predicting tumor response. "We have already published over a hundred scientific articles on our website from world-leading research groups that have used Modulight products in their studies. This Continue reading →

World Congress organized by Modulight and the International Photodynamic Association brings world leading experts in Photodynamic therapy to Tampere

During this week, Tampere Hall will be filled with experts and scientists in photodynamic therapy as the international congress organized by Modulight gets underway. The biennial congress, the scientific content of which are carefully screened by the International Photodynamic Association (IPA), will give medical researchers, and doctors the opportunity to share their ideas, research results and new discoveries in the field of medicine and technology. The congress, which starts on Monday 10 July, will be opened by Anna-Kaisa Ikonen, Minister of Local Government of Finland, Continue reading →

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Press releases archive



2010–2015

16 Sep 2015 Rising star in immunotherapy competition »

28 Jan 2015 Modulight launches the world’s first multi indication CE and ETL certified medical laser »

09 Sep 2014 Modulight ML7710-PDT laser platform CB testing completed »

30 Jan 2014 Modulight broadens their OEM laser system family to single-mode and multi-wavelength laser modules »

14 Nov 2013Modulight launches a product family for photodynamic therapy »

29 Aug 2013Modulight launches a turnkey OEM laser system platform to photodynamic therapy »

20 Jun 2013Kalle Palomaki nominated to Modulight Board »

28 Jan 2013Modulight launches new 1W RGB LimeLight laser modules with the smallest form factor in the industry »

01 Nov 2012Medical Design Briefs: Therapeutic Laser Systems Improve Quality of Life and Save in Healthcare »

17 Apr2012Modulight receives a contract for manufacturing CE certified medical laser systems for cancer therapy »

15 Nov 2011Modulight expands LimeLight product family with blue wavelength »

06 Oct 2011Modulight receives ISO 13485:2003 certification for medical laser manufacturing »

19 May 2011Modulight releases multi-chip red laser modules for industrial, display and medical applications »

20 Jan 2011LimeLight laser systems on display in Photonics West at booth #4635 »

13 Jan 2011Modulight adds features and scales up power from FiberLight product platform »

11 Nov 2010Modulight releases OEM laser systems for medical and industrial applications »

16 Sep 2010Modulight releases high-power single-mode lasers at 1310-1650nm for OTDR »

25 Aug 2010Modulight celebrates 10 years anniversary with 35% growth in business »

26 May 2010Modulight welcomes summer by releasing a series of colourful and powerful mounted single-emitters »

30 Apr 2010Modulight appoints new partners in Italy and Singapore »


2008–2009

10 Dec 2009Modulight turning Christmas all red, by adding new red lasers to ChiliLase product »

21 Oct 2009Modulight lasers launched to space on ESA’s SMOS satellite mission »

06 Oct 2009Modulight appoints distribution partner in the United Kingdon and Republic of Ireland »

20 May 2009Modulight establishes distribution partner in China and wins new contract for laser display application »

14 May 2009Modulight celebrates spring by releasing a series of colourful Butterfly lasers »

02 Apr 2009Modulight announces 7 Watt 635nm Conduction Cooled Diode Laser; Applications include Laser Display, Medical, and Illumination »

26 Jan 2009Modulight “FiberLight”, the platform for fiber-coupled high-power lasers from 635 nm to 1550 nm »

14 Nov 2008Modulight introduces “SparkLight”, the turnkey platform for high-power lasers »

06 Nov 2008Modulight scales up power to 20 W at 1470 nm »

11 Sep 2008Modulight receives 2008 Frost & Sullivan Award for North American Laser Diode Emerging Company of the Year »

04 Sep 2008A new generation of high-power collimated laser modules shines from Modulight »

28 Aug 2008Modulight introduces 1470 nm high-power lasers »

19 Jun 2008Modulight introduces 830 nm high-power lasers »

29 May 2008Modulight to continue supply agreement with Vaisala for meteorological applications »

08 May 2008Modulight to develop high-brightness pump laser technology for European Space Agency »

06 Mar 2008Modulight’s RangerLase provides up to 20 W laser power at 1550 nm »

01 Feb 2008ROAD MONITORING: Laser systems monitoring slipperiness of roadways (Laser Focus World, February 2008) »




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