Modulight news & articles

Published in: Cytometry Part B: Clinical Cytometry Authors: Alice Yue, Ryan R. Brinkman, Veronica Nash, Fabian Junker, Goce Bogdanoski, Anagha Divekar, Aaron Tyznik, Josef Spidlen, Wolfgang Kern, Jordi Petriz, Kaska Wloka, Kamila Czechowska  

Published in: Cancer Immunology, Immunotherapy Authors: Motofumi Suzuki, Aki Furusawa, Hiroshi Yamamoto, Makoto Kano, Miyu Kano, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi  

Published in: Annals of Medicine Authors: Aki Furusawa ,Seiichiro Takao, Motofumi Suzuki, Makoto Kano, Hiroshi Yamamoto, Miyu Kano, Peter Choyke, Hisataka Kobayashi  

Published in: Langmuir Authors: Sumiao Pang, Rebecca J. Johnson, Nikhil Pandey, Anshika Kapur, Pavlos Anastasiadis, Pranjali Kanvinde, Emylee McFarland, Jeffrey A. Winkles, Graeme F. Woodworth, Anthony J. Kim, Huang Chiao Huang  

Published in: npj Acoustics Authors: Andrew Langley, Allison Sweeney, Ronak T. Shethia, Brooke Bednarke, Faizah Wulandana, Marvin Xavierselvan, Srivalleesha Mallidi  

Published in: Bioengineering & Translational Medicine Authors: Chen-Hua Ma, Jeffrey Yang, John A. Quinlan, Kathryn McNaughton, Michele L. Kaluzienski, Tessa Hauser, Matthew F. Starost, Jenna L. Mueller, Huang-Chiao Huang  

Age-related Macular Degeneration (AMD) Age-related Macular Degeneration (AMD) is a disease causing choroidal neovascularization (CNV) and consequent irreversible damage in the macula. AMD is classified into dry (atrophic) and wet (exudative) forms, with the latter causing faster vision loss and being the leading cause of blindness in people over 65. Introduction to AMD Age-related Macular [...]

Next generation flow cytometry Lasers have been historically the key light sources utilized in flow cytometry due to their ability to deliver the precise amount of energy needed to trigger the Stokes shift, which is the key phenomena underlying flow cytometry operation. For the same reason lasers and optical system in general are referred to [...]

Background Photobiomodulation with low-level laser or light therapy is an effective treatment for pain. It has various effects, such as analgesic (pain-relieving) effects, anti-inflammatory effects, tissue regeneration promoting effects, and wound healing effects. Photobiomodulation can be used to relief both acute and chronic pain and has the advantage of being noninvasive and safe. Earlier studies […]

Background The proper delivery and release of therapeutic drugs to a specific site or cell type is one of the main challenges in the treatment of diseases. Liposomes, which are vesicles composed of lipids, serve as carriers for drug delivery thanks to their long circulation time. This results to reduced toxicity in healthy tissues and […]

Deadliest cancer Precision with photoactivation Photoimmunotherapy with ML7710 offers a clinical therapeutic option for NSCLC patients even with advanced disease stage. Besides laser light, this therapy involves photoactivated drug, which can be activated precisely at the tumor site with laser fibers, hence minimizing drug effects to healthy tissues. Smaller invasiveness compared to surgery can enable […]

Introduction to DRB lasers Distributed Bragg Reflector (DBR) laser diodes are a class of single-frequency monolithic semiconductor lasers. Monolithic semiconductor lasers in general are small in size, mechanically robust, and have good power conversion efficiency. They also provide opportunities for hybrid integration with photonic integrated circuits (PICs). This application note provides an overview of DBR [...]

This month we are highlighting exciting findings by S. Takao et al. from Hisataka Kobayashi’s lab at the National Cancer Institute, NIH. Published in Cancer Letters, the study shows that near-infrared photoimmunotherapy can destroy cancer cells by targeting intercellular adhesion molecule-1.

Published in journal Cancer Medicine, the study shows that the therapeutic effect of photoimmunotherapy is highly dependent on the used light irradiation conditions. Application of the ML7710 medical laser at different durations and powers resulted in highest anti-tumor effect with increased light dose but lowering fluence rate below what is currently used in clinic.

Laser-sharp research of the month is by Furusawa et al. at Center for Cancer Research, National Cancer Institute, USA. The discovery, published in Annals of Medicine, showed the potential of photoimmunotherapy for treating breast cancer. To expand the usefulness of photoimmunotherapy outside the clinically approved head & neck indication, the new therapy targeted epithelial cell adhesion molecule in breast cancer.

The spotlight of the month goes to Andrew Langley et al. at Tufts University, USA, for their impressive work in leveraging photoacoustic imaging for real-time monitoring of phototherapy. Photoacoustic imaging is 3D, non-ionizing and non-invasive imaging method, based on optical absorption that creates pressure waves detected by ultrasound transducer.

Chen-Hua Ma et al. ​​Optical Therapeutics & Nanotechnology Laboratory at University of Maryland combined photoimmunotherapy with ethanol ablation to achieve improved drug retention and light penetration, especially important for treating pigmented organs like liver and pancreas. Modulight’s ML7710 laser was used for both therapeutic activation of the nanoconstruct, as well as for theranostic monitoring of the process.

Cheng-Yu Lai et al. at Florida International University explores a solution for antibiotic-free wound healing. A photothermally controllable hydrogel was illuminated by NIR light from ML6600 laser, causing complete eradication of bacteria.

Introducing Modulight’s Versatile DBR Laser platform Modulight announces the launch of its latest Distributed Bragg Reflector (DBR) lasers, offering a configurable wavelength range from 630 nm to 1100 nm. These advanced lasers are designed to meet the high demands in quantum systems, quantum sensing, Raman spectroscopy, and metrology.  Key wavelengths of Modulight DBR laser platform [...]

Advancing Flow Cytometry Precision with VECSEL-Based Flow Cytometry Lasers Modulight expands its ML6600 product family with new high-performance flow cytometry lasers designed to meet the rigorous demands of cell analysis and sorting. Featuring Modulight’s OP-VECSEL (Optically-Pumped Vertical-External-Cavity Surface-Emitting Laser) core technology, these latest ML6600 variants offer unparalleled stability, beam quality, and efficiency for biomedical research [...]

Modulight Introduces High-Performance Tapered Amplifiers and DBR MOPA Devices Modulight is broadening its advanced laser solutions portfolio with a range of tapered amplifier products and monolithic DBR MOPA devices, delivering high output power with excellent beam quality.  Designed for Master Oscillator Power Amplifier (MOPA) configurations, Modulight’s tapered amplifiers ensure efficient amplification while preserving the seed [...]

Modulight Introduces ML6640: Redefining Flow Cytometry Performance

Introducing VECSEL Technology to the Modulight ML6600 Platform for Quantum Applications Modulight ML6600 Expands to Meet Quantum Application Needs Modulight is proud to announce new additions to its ML6600 product platform, tailored specifically for quantum applications. Building on the proven ML6600 platform, these latest variants integrate Modulight’s innovative VECSEL (Vertical-External-Cavity Surface-Emitting Laser) core technology, redefining [...]

Modulight proudly announces new variants of its ML6600 platform, designed specifically for the demanding requirements of microscopy illumination, such as super-resolution microscopy. These advanced solutions support both single-wavelength and multi-wavelength configurations, tailored to meet diverse customer needs in imaging applications. ML6600 platform provides all key wavelengths for microscopy—for example 355nm, 405 nm, 488 nm, 532nm, 561 nm, and 638 nm.