Modulight news & articles

Modulight news & articles

Research Articles

Engineering Photodynamics for Treatment, Priming and Imaging

Published in: Nature Reviews Bioengineering Authors: Girgis Obaid, University of Texas at Dallas Jonathan P. Celli, University of Massachusetts Boston Mans Broekgaarden, Grenoble Alpes University Anne-Laure Bulin, Grenoble Alpes University Petteri Uusimaa, Modulight Corporation Brian Pogue, University of Wisconsin School of Medicine Tayyaba Hasan, Harvard Medical School Huang-Chiao Huang, University of Maryland   The review article explores the advanced applications of PDT, a photochemistry-based treatment approach that utilizes light-activated photosensitizers to generate reactive oxygen species for localized cellular cytotoxicity. The paper discusses the underlying mechanisms Continue reading →

Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells

Published in: eBioMedicine Authors: Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S. Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L. Choyke, Martin J. Schnermann, Hisataka Kobayashi A new method called phototruncation-assisted cell tracking (PACT) can be used to noninvasively track migration of immune cells to understand anti-cancer immunity mechanisms. PACT is based on irreversible photo-induced truncation reaction, transforming Cy7 into Cy5 when exposed to NIR light (780 nm). PACT was used in this study to monitor spatiotemporal migration of immune cells between tumor and Continue reading →

Carrier-Free, Amorphous Verteporfin Nanodrug for Enhanced Photodynamic Cancer Therapy and Brain Drug Delivery

Published in: Advanced Science Authors: John A. Quinlan, Collin T. Inglut, Payal Srivastava, Idrisa Rahman, Jillian Stabile, Brandon Gaitan, Carla Arnau Del Valle, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Baktiar Karim, Nina Connolly, Robert W. Robey, Graeme F. Woodworth, Michael M. Gottesman, Huang-Chiao Huang University of Maryland Glioblastoma (GBM) is hard to treat due to cellular invasion into functioning brain tissues, limited drug delivery, and evolved treatment resistance. Recurrence is nearly universal even after surgery, chemotherapy, and radiation. Photodynamic therapy (PDT) involves photosensitizer administration followed by light activation to generate reactive oxygen species at tumor sites, thereby killing cells or Continue reading →

Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids

Published in: Cell & Bioscience Authors: Aaron Sorrin, Anika Dasgupta, Kathryn McNaughton, Carla Arnau Del Valle, Keri Zhou, Cindy Liu, Dana M. Roque & Huang Chiao Huang Within the last decade, poly(ADP-ribose) polymerase inhibitors (PARPi) have emerged in the clinic as an effective treatment for numerous malignancies. Preclinical data have demonstrated powerful combination effects of PARPi paired with photodynamic therapy (PDT), which involves light-activation of specialized dyes (photosensitizers) to stimulate cancer cell death through reactive oxygen species generation. In this study, a novel combination strategy was Continue reading →

Multiwavelength narrow linewidth laser system for Ba+ quantum computing applications

Published in: QUANTUM WEST SPIE 2024 Authors: Kostiantyn Nechay, Luukas Kuusela, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa Quantum information processing (QIP) approach based on trapped ions is a promising technology that exploits different ion species as individual qubits and qubit gates, while featuring long coherence times, high fidelity of operations, fast readout, and ion-ion gate entanglement. The practical usefulness of trapped-ion quantum computer depends on its further scaling to a large number of qubits. Meanwhile, trapped-ion quantum computer relies on a set of single-frequency lasers, utilizing Continue reading →

Narrow linewidth 650 nm DBR laser diode for quantum applications

Published in: QUANTUM WEST SPIE 2024 Authors: Riina Ulkuniemi, Luukas Kuusela, Mika Mähönen, Timo Aho, Jussi Hämelahti, Andreas Schramm, Soile Talmila, Pekko Sipilä, Petteri Uusimaa Laser systems are utilized in quantum for various applications. Multiple wavelengths and tailored solutions are required depending on the technology that the laser will be applied to. For instance, lasers can be used for controlling particles and molecules, including excitations of the quantum systems. Key performance requirements for lasers used in these applications include narrow linewidth, frequency stability, and single-frequency Continue reading →

Application notes

AI-based laser alignment for Flow Cytometry

Next generation flow cytometry Lasers have been historically the key light sources utilized in flow cytometry due to their ability to deliver the precise amount of energy needed to trigger the Stokes shift, which is the key phenomena underlying flow cytometry operation. For the same reason lasers and optical system in general are referred to as the “heart of flow cytometer”, since they are the integral component initiating the instrument operation. To ensure smooth and repeatable flow cytometer performance laser source needs to exhibit excellent Continue reading →

Photobiomodulation for pain treatment using ML6600

Customer case University of Toyama is a Japanese national university located in Toyama City and Takaoka City and established in 1949. It is comprised of 3 former national universities Toyama University, Toyama Medical and Pharmaceutical University, and Takaoka National College. Naoya Ishibashi Daisuke Uta Modulight products: ML6600 Laser use: Studying pain treatment with photobiomodulation. Links to articles:     Background Photobiomodulation with low-level laser or light therapy is an effective treatment for pain. It has various effects, such as analgesic (pain-relieving) effects, anti-inflammatory effects, tissue regeneration Continue reading →

Development of thermosensitive liposomes with the help of ML8500

Customer case Pharmaceutical Nanotechnology Group at University of Helsinki is specialized in top-level pharmaceutical research. Led by Professor Timo Laaksonen, the group focuses on controlled drug release and delivery using modern methods and materials. Particular interest lies in using light to both monitor nanomaterial behavior and to trigger e.g. drug release processes. Modulight products: ML8500, ML6600, MLAKIT   Prof. Timo Laaksonen Dr. Tatu Lajunen Laser use: Light-triggered drug release studies from light-activated liposomes. ML8500 with 808 nm wavelength was used to induce the release of calcein from liposomes under Continue reading →

ML7710 for photoactivated treatment of lung cancer

Deadliest cancer Lung cancer is the leading cause of cancer deaths worldwide, with more than 2.2 million cases and 1.8 million deaths each year [1]. Lung cancer can be divided into two types, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), with the latter accounting for about 85% of all lung cancer cases. NSCL is usually less sensitive to chemo- and radiotherapy and in many cases tumor cannot be removed surgically or has spread from lungs to distant sites at the time Continue reading →

Distributed Bragg Reflector (DBR) Laser Diodes

Introduction to DRB lasers Distributed Bragg Reflector (DBR) laser diodes are a class of single-frequency monolithic semiconductor lasers. Monolithic semiconductor lasers in general are small in size, mechanically robust, and have good power conversion efficiency. They also provide opportunities for hybrid integration with photonic integrated circuits (PICs). This application note provides an overview of DBR lasers, their principles of operation, their modal behavior, and their diverse applications. Principles of DBR Laser Operation A DBR laser is a semiconductor laser with one or several quantum wells Continue reading →

Light-induced drug delivery with indocyanine green liposomes

Customer case Faculty of Pharmacy at University of Helsinki is specialized in top-level pharmaceutical research. Multidisciplinary research fields include clinical pharmacy, experimental drugs, nanomedicines, and pharmaceutical drug design. Drug delivery unit led by Professor Arto Urtti focuses on design and testing of advanced drug delivery systems especially for ocular indications. Light is studied as an important tool to control the drug delivery to the target tissues. Modulight products: ML6600 (810 nm) + Modulight in vitro illumination kit (MLAKIT) Professor Arto Urtti   Senior Pharmaceutical Researcher Tatu Continue reading →

Laser-Sharp Research

Modulight Spotlights: LASER-SHARP RESEARCH – June 2024

Modulight Spotlights: LASER-SHARP RESEARCH – June 2024 A promising new therapy against viruses was developed at University of Manitoba and Theralase Technologies. Infectious agents are a global problem, causing millions of deaths every year. The study evaluated antiviral effectiveness of a cancer drug (Ruvidar), which is currently in clinical development for bladder cancer. When this drug was activated with green laser using Modulight’s ML6600, it resulted in a rapid elimination of many different human viruses. Impressively, it was >99% effective at low doses in inactivating human coronavirus, influenza Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – May 2024

Modulight Spotlights: LASER-SHARP RESEARCH – May 2024 A new publication by Professor Bryan Spring and his team at Northeastern University has shown promising results for improved photoimmunotherapy protocols using patient-derived ovarian cancer cells. Using Modulight’s ML6000-series laser as part of the new protocol, they successfully minimized non-specific damage to cells that was caused by a small fraction of non-covalently bound (free) photosensitive drug, which is typically cleared in vivo by lymph and blood flow. They also showed the importance of using more biologically relevant cancer Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – April 2024

Modulight Spotlights: LASER-SHARP RESEARCH – April 2024 First-in-human, phase 1 clinical trial results with ML7710 have been published in a renowned journal Radiology by Timothy Baran and team at University of Rochester Medical Center. The trial investigated treatment of deep tissue abscesses using photodynamic therapy with methylene blue and ML7710 laser. Abscesses are painful collection of pus, usually caused by a bacterial infection. Standard treatment is abscess drainage and antibiotics, however treatment responses vary widely and are linked to prolonged hospital stay, costs, and patient discomfort, as well as increasing concerns for antibiotic-resistance. The trial in 18 Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – March 2024

Modulight Spotlights: LASER-SHARP RESEARCH – March 2024 Glioblastoma is the most aggressive type of brain tumor. It is hard to treat because of its invasion into functioning brain tissues, limited drug delivery due to blood-brain-barrier, and evolved treatment resistance. To address these challenges, a light-activated nanoformulation, called nanoVP, was developed for glioblastoma in a new study co-led by John Quinlan and Collin Inglut in Dr. Huang’s team at the University of Maryland. Published in a prestigious journal Advanced Science, this novel therapy resulted in an improved tumor control and survival Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – February 2024

Modulight Spotlights: LASER-SHARP RESEARCH – February 2024 Photoactivated chemotherapy (PACT) is a novel anticancer therapy where cytotoxic drug is attached into a photocage, which is cleaved by light to release the drug at the tumor site. A new study led by Prof. Sylvestre Bonnet’s group at Leiden University, demonstrated a significantly improved agent for photoactivated chemotherapy. ML6600 laser was used to study the drug release from the photocage, comparing efficacy between red and green light. It was shown that the agent could be effectively released Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – January 2024

Modulight Spotlights: LASER-SHARP RESEARCH – January 2024 Phototherapy is widely established treatment for skin diseases like actinic keratosis, cutaneous infections, and skin tumors, resulting in excellent cosmetic outcomes. However, some clinically used light sensitizing drugs have drawbacks such as limited penetration depth and high painfulness to patient. In a new study by Andreea Burloiu and the teams at Carol Davila University of Medicine and Pharmacy, new photoactivated drugs were developed for treatment of skin diseases. ML6600 laser with MLAKIT was used to evaluate the effect Continue reading →

Press releases

Photodynamic Therapy for Cancer Treatment – Review Article by Nature

Modulight Corp., a leader in innovative laser solutions, is proud to announce a significant contribution to the field of cancer treatment through the publication of a comprehensive review on Photodynamic Therapy (PDT) in Nature Reviews Bioengineering. This review article, co-authored by Modulight’s CTO Dr. Petteri Uusimaa, alongside several other leading experts, highlights the transformative potential of PDT in cancer treatment, priming, and imaging. The review article, titled “Engineering Photodynamics for Treatment, Priming, and Imaging”, explores the advanced applications of PDT, a photochemistry-based treatment approach that Continue reading →

ML6600 Multiwavelength Distributed Bragg Reflector Laser Platform for Quantum Applications

Modulight ML6600 Distributed Bragg Reflector laser cores are available at various wavelengths - 650 nm, 760 nm, 780 nm, 785 nm, 795 nm, and 935 nm - relevant to quantum and spectroscopy applications. The fully in-house manufactured laser diodes exhibit reliable high-power operation with down to below 500 kHz linewidth. Designed for highest-quality mechanical, optical and acoustical isolation, and integrated with ML6600 platform’s ultra-low-noise current drivers and accurate temperature controllers, these laser cores show top-notch performance. Both free-space output and single-mode polarization maintaining fiber are Continue reading →

ML6600 Narrow linewidth VECSEL for photoionization of Ba for trapped ion computing

Modulight’s in-house vertical-external-cavity surface-emitting laser (VECSEL) technology integration into ML6600 laser cores paves the way for Barium trapped ion applications at wavelengths 493 nm, 532 nm and 553 nm, featuring free-running linewidth of <100 kHz with Watt-level emission. Linewidth can be further narrowed using linewidth narrowing techniques such as Pound-Drever Hall method and a stable reference. Modulight ML6600 VECSEL laser platform offers scalable and tunable high-power single-frequency emission pumped by inexpensive multimode lasers. VECSELs possess several advantages as a narrow linewidth laser platform. The external Continue reading →

ISO 27001 – information security standard for Modulight

Modulight achieved the international ISO 27001 information security standard certification today on February 28, 2024. The certification of the information security management system demonstrates the organization's commitment to protecting information and managing high-level of information security. "We are expanding the use of cloud services in accordance with our SaaS business model and are making strong progress in transitioning to a pay-per-treatment (PPT) payment model. Managing patient information requires very high-level information security processes, which is why we started to pursue the ISO 27001 certification in Continue reading →

Modulight Announces Involvement in GlioLighT Project for Glioma Treatment

Modulight is pleased to announce its participation in the GlioLighT project, aimed at developing new treatment options for gliomas. This project has received substantial funding of approximately EUR 2.2 million over three years from the European Innovation Council's Pathfinder program. The GlioLighT project partners include Johannes Gutenberg University Mainz, Aston University in Birmingham, the University of Barcelona, LMU Munich, and MODUS Research and Innovation Ltd. The budgetary allotment of the project for Modulight is about EUR 400,000 over the duration of the project. Gliomas, known Continue reading →

Modulight Forges Strategic Partnership with Laser 2000 UK for Market Expansion in the UK and Ireland

Modulight is pleased to announce a sales partnership with Laser 2000 UK Ltd, a renowned reseller of laser-based solutions in the UK and Ireland. The partnership marks a significant step in expanding Modulight's presence in the UK and Irish markets, leveraging Laser 2000 UK's established customer base, broad sales team, and technical expertise. Under this collaboration, Laser 2000 UK will integrate Modulight's cutting-edge laser technologies into their diverse range of photonics solutions. This synergy is expected to enrich Laser 2000 UK's system solutions offering, particularly Continue reading →

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Press releases archive



2010–2015

16 Sep 2015 Rising star in immunotherapy competition »

28 Jan 2015 Modulight launches the world’s first multi indication CE and ETL certified medical laser »

09 Sep 2014 Modulight ML7710-PDT laser platform CB testing completed »

30 Jan 2014 Modulight broadens their OEM laser system family to single-mode and multi-wavelength laser modules »

14 Nov 2013Modulight launches a product family for photodynamic therapy »

29 Aug 2013Modulight launches a turnkey OEM laser system platform to photodynamic therapy »

20 Jun 2013Kalle Palomaki nominated to Modulight Board »

28 Jan 2013Modulight launches new 1W RGB LimeLight laser modules with the smallest form factor in the industry »

01 Nov 2012Medical Design Briefs: Therapeutic Laser Systems Improve Quality of Life and Save in Healthcare »

17 Apr2012Modulight receives a contract for manufacturing CE certified medical laser systems for cancer therapy »

15 Nov 2011Modulight expands LimeLight product family with blue wavelength »

06 Oct 2011Modulight receives ISO 13485:2003 certification for medical laser manufacturing »

19 May 2011Modulight releases multi-chip red laser modules for industrial, display and medical applications »

20 Jan 2011LimeLight laser systems on display in Photonics West at booth #4635 »

13 Jan 2011Modulight adds features and scales up power from FiberLight product platform »

11 Nov 2010Modulight releases OEM laser systems for medical and industrial applications »

16 Sep 2010Modulight releases high-power single-mode lasers at 1310-1650nm for OTDR »

25 Aug 2010Modulight celebrates 10 years anniversary with 35% growth in business »

26 May 2010Modulight welcomes summer by releasing a series of colourful and powerful mounted single-emitters »

30 Apr 2010Modulight appoints new partners in Italy and Singapore »


2008–2009

10 Dec 2009Modulight turning Christmas all red, by adding new red lasers to ChiliLase product »

21 Oct 2009Modulight lasers launched to space on ESA’s SMOS satellite mission »

06 Oct 2009Modulight appoints distribution partner in the United Kingdon and Republic of Ireland »

20 May 2009Modulight establishes distribution partner in China and wins new contract for laser display application »

14 May 2009Modulight celebrates spring by releasing a series of colourful Butterfly lasers »

02 Apr 2009Modulight announces 7 Watt 635nm Conduction Cooled Diode Laser; Applications include Laser Display, Medical, and Illumination »

26 Jan 2009Modulight “FiberLight”, the platform for fiber-coupled high-power lasers from 635 nm to 1550 nm »

14 Nov 2008Modulight introduces “SparkLight”, the turnkey platform for high-power lasers »

06 Nov 2008Modulight scales up power to 20 W at 1470 nm »

11 Sep 2008Modulight receives 2008 Frost & Sullivan Award for North American Laser Diode Emerging Company of the Year »

04 Sep 2008A new generation of high-power collimated laser modules shines from Modulight »

28 Aug 2008Modulight introduces 1470 nm high-power lasers »

19 Jun 2008Modulight introduces 830 nm high-power lasers »

29 May 2008Modulight to continue supply agreement with Vaisala for meteorological applications »

08 May 2008Modulight to develop high-brightness pump laser technology for European Space Agency »

06 Mar 2008Modulight’s RangerLase provides up to 20 W laser power at 1550 nm »

01 Feb 2008ROAD MONITORING: Laser systems monitoring slipperiness of roadways (Laser Focus World, February 2008) »




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