Modulight Spotlights: LASER-SHARP RESEARCH – March 2025

March 19, 2025 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – March 2025 Bladder cancer is the fourth most common cancer in men, and despite good prognosis, recurrences are very common with standard therapies. In a new publication by Jonathan Coleman and the group at the Memorial Sloan Kettering Cancer Center, vascular-targeted therapy was studied for bladder cancer as a minimally invasive treatment option. The therapy involves a photosensitive drug, padeliporfin, which binds to blood albumin and accumulates to tumor vasculature. When the bladder was illuminated with the Modulight’s ML7710 laser, Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – February 2025

February 17, 2025 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – February 2025 This month’s spotlight goes to A. Lepland and the teams at University of Tartu, Estonia and Veneto Institute of Oncology, Italy, who developed a new immunotherapy for triple negative breast cancer. This subtype of breast cancer is often very aggressive and notoriously difficult to treat as it lacks hormone receptors. In the new publication in Advanced Science, researchers developed a peptide-drug conjugate against tumor-promoting immune cells that suppress the immune response against tumor. The developed drug consists of Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – January 2025

January 22, 2025 by Modulight Content
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   Modulight Spotlights: LASER-SHARP RESEARCH – January 2025 We are pleased to highlight this month a new study published in Cancer Immunology, Immunotherapy by Hisataka Kobayashi’s team at National Cancer Institute, NIH. They developed light-activated immunotherapy targeting a specific protein found on the surface of many cancer cells, called tissue factor. This therapy consists of antibody-photoabsorber conjugate that binds to cancer cell surface, and in response to near-infrared light, induces photochemical reaction that results in membrane destruction and immunogenic cell death. When this novel agent was Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – December 2024

December 17, 2024 by Modulight Content
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   Modulight Spotlights: LASER-SHARP RESEARCH – December 2024 This month we are highlighting work by Timothy C. Zhu and the team at University of Pennsylvania, USA. They have investigated the use of photodynamic therapy for mesothelioma, an aggressive cancer that usually occurs in the thin layer of tissue that lines the lungs and is typically caused by asbestos exposure. 24 malignant pleural mesothelioma patients were treated with photodynamic therapy using Photofrin and the ML7710 laser following surgical tumor debulking. The researchers derived oxygenation information inside the Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – November 2024

November 19, 2024 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – November 2024 The lungs are common site of cancer metastasis, with isolated pulmonary metastases most often affecting patients with colorectal cancer and sarcomas. Surgical metastasectomy is the standard treatment, however, only 1 in 10 patients qualify for surgical resection thus the management remains a significant clinical challenge. To tackle this challenge, K. Ramadan et al. studied photodynamic therapy in an isolated lung perfusion model where the blood is replaced with acellular perfusate, allowing greater light penetration. The feasibility and safety Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – October 2024

October 24, 2024 by Modulight Content
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Modulight Spotlights: LASER-SHARP RESEARCH – October 2024 This month, we are highlighting new findings published in RSC Materials Advances by Olga Lem, Roosa Kekki and researchers at Pharmaceutical Nanotechnology research group and Tampere University. The study provides key insights into the role of lipid oxidation in cargo release from light-activated liposomes. These spherical lipid vesicles can be controlled by light to provide time- and site-specific drug delivery, for example for cancer treatment. Red light provides a non-invasive, selective, and safe trigger for releasing liposomal cargo. Modulight’s Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – September 2024

September 23, 2024 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – September 2024 University of Maryland and Modulight have published together a new research study about the mechanisms of cancer drug resistance. Drug resistance is a leading cause of treatment failure and often has dramatic consequences for survival of cancer patients. Cancer cells have developed various ways to protect themselves from drugs. When several clinically used photoactive drugs were studied, it was shown that some of them were being actively pumped out by cancer cells, thus likely limiting the full therapeutic potential Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – August 2024

August 7, 2024 by Modulight Content
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                    Modulight Spotlights: LASER-SHARP RESEARCH – August 2024 This month’s research highlight goes to Hirofumi Hanaoka and the team at Kansai Medical University, Japan. They developed a new laser fiber and method for illumination of narrow cavities, such as esophagus. With typical laser fibers, it is difficult to precisely illuminate target tumor in a narrow space at an oblique angle, since there is not enough space for fiber bending. The new lateral (side) emitting laser fiber was developed and evaluated for near-infrared photoimmunotherapy, which combines light, Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – July 2024

July 26, 2024 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – July 2024 Exciting new findings in prostate cancer research were reported by Xinning Wang and team at Case Western University, Comprehensive Cancer Center. Prostate cancer is the most common cancer among men and despite typically good prognosis, is a leading cause of cancer-related death. In the new study, the team combined chemotherapy with a novel light-activated, theranostic agent to enable targeted imaging and treatment of prostate cancer. Using ML7710 laser at 672 nm for activation of the drug, they were Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – June 2024

June 12, 2024 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – June 2024 A promising new therapy against viruses was developed at University of Manitoba and Theralase Technologies. Infectious agents are a global problem, causing millions of deaths every year. The study evaluated antiviral effectiveness of a cancer drug (Ruvidar), which is currently in clinical development for bladder cancer. When this drug was activated with green laser using Modulight’s ML6600, it resulted in a rapid elimination of many different human viruses. Impressively, it was >99% effective at low doses in inactivating human coronavirus, influenza Continue reading →