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Articles by Modulight and customers

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Self-Assembled Verteporfin Nanoparticles for Photodynamic and Light-Independent Therapy in Glioblastoma
Advanced NanoBioMed Research

Self-Assembled Verteporfin Nanoparticles for Photodynamic and Light-Independent Therapy in Glioblastoma

John A. Quinlan, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Robert W. Robey, Michael M. Gottesman, Huang-Chiao Huang
September 28, 2024
Screening of photosensitizers-ATP binding cassette (ABC) transporter interactions in vitro
Cancer Drug Resistance

Screening of photosensitizers-ATP binding cassette (ABC) transporter interactions in vitro

Shruti Vig, Payal Srivastava, Idrisa Rahman, Renee Jaranson, Anika Dasgupta, Robert Perttilä, Petteri Uusimaa, Huang-Chiao Huang
September 20, 2024
Engineering Photodynamics for Treatment, Priming and Imaging
Nature Reviews Bioengineering

Engineering Photodynamics for Treatment, Priming and Imaging

Girgis Obaid, Jonathan Celli, Mans Broekgaarden, Anne-Laure Bulin, Petteri Uusimaa, Brian Pogue, Tayyaba Hasan, Huang-Chiao Huang
June 19, 2024
Comparative study of immune response to local tumor destruction modalities in a murine breast cancer model
Frontiers in Oncology

Comparative study of immune response to local tumor destruction modalities in a murine breast cancer model

Sadna Budhu, Kwanghee Kim, Wesley Yip, Stephen La Rosa, Sylvia Jebiwott, Liqun Cai, Aliya Holland, Jasmine Thomas, Dina Preise, Alex Somma, Benjamin Gordon, Avigdor Scherz, Jedd D. Wolchok, Joseph Erinjeri, Taha Merghoub, Jonathan A. Coleman
June 18, 2024
Ru(II) Oligothienyl Complexes with Fluorinated Ligands: Photophysical, Electrochemical, and Photobiological Properties
Inorganic Chemistry

Ru(II) Oligothienyl Complexes with Fluorinated Ligands: Photophysical, Electrochemical, and Photobiological Properties

Houston D. Cole, Abbas Vali, John A. Roque III, Ge Shi, Alisher Talgatov, Gurleen Kaur, Antonio Francés-Monerris, Marta E. Alberto, Colin G. Cameron, Sherri A. McFarland
May 10, 2024
Near‐infrared photoimmunotherapy targeting PD‐L1: Improved efficacy by preconditioning the tumor microenvironment
Cancer Science

Near‐infrared photoimmunotherapy targeting PD‐L1: Improved efficacy by preconditioning the tumor microenvironment

Fuyuki F. Inagaki, Makoto Kano, Aki Furusawa, Takuya Kato, Ryuhei Okada, Hiroshi Fukushima, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi
April 26, 2024
Near-infrared photoimmunotherapy targeting Nectin-4 in a preclinical model of bladder cancer
Cancer Letters

Near-infrared photoimmunotherapy targeting Nectin-4 in a preclinical model of bladder cancer

Hiroshi Fukushima, Seiichiro Takao, Aki Furusawa, Vladimir Valera Romero, Sandeep Gurram, Takuya Kato, Shuhei Okuyama, Makoto Kano, Peter L. Choyke, Hisataka Kobayashi
March 31, 2024
Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells
eBioMedicine

Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells

Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S. Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L. Choyke, Martin J. Schnermann, Hisataka Kobayashi
March 14, 2024
Photoimmuno-antimicrobial therapy for Staphylococcus aureus implant infection
PLoS One

Photoimmuno-antimicrobial therapy for Staphylococcus aureus implant infection

Bruce van Dijk, Sabrina Oliveira, J. Fred F. Hooning van Duyvenbode, F. Ruben H. A. Nurmohamed, Vida Mashayekhi, Irati Beltrán Hernández, Jos van Strijp, Lisanne de Vor, Piet C. Aerts, H. Charles Vogely, Harrie Weinans, Bart C. H. van der Wal
March 8, 2024
Carrier-Free, Amorphous Verteporfin Nanodrug for Enhanced Photodynamic Cancer Therapy and Brain Drug Delivery
Advanced Science

Carrier-Free, Amorphous Verteporfin Nanodrug for Enhanced Photodynamic Cancer Therapy and Brain Drug Delivery

John A. Quinlan, Collin T. Inglut, Payal Srivastava, Idrisa Rahman, Jillian Stabile, Brandon Gaitan, Carla Arnau Del Valle, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Baktiar Karim, Nina Connolly, Robert W. Robey, Graeme F. Woodworth, Michael M. Gottesman, Huang-Chiao Huang
March 6, 2024
Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids
Cell & Bioscience

Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids

Aaron Sorrin, Anika Dasgupta, Kathryn McNaughton, Carla Arnau Del Valle, Keri Zhou, Cindy Liu, Dana M. Roque & Huang Chiao Huang
February 6, 2024
Multiwavelength narrow linewidth laser system for Ba+ quantum computing applications
QUANTUM WEST SPIE 2024

Multiwavelength narrow linewidth laser system for Ba+ quantum computing applications

Kostiantyn Nechay, Luukas Kuusela, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa
January 31, 2024
Narrow linewidth 650 nm DBR laser diode for quantum applications
QUANTUM WEST SPIE 2024

Narrow linewidth 650 nm DBR laser diode for quantum applications

Riina Ulkuniemi, Luukas Kuusela, Mika Mähönen, Timo Aho, Jussi Hämelahti, Andreas Schramm, Soile Talmila, Pekko Sipilä, Petteri Uusimaa
January 31, 2024
Narrow linewidth VECSELs for Ba+ cooling at 493 nm
LASE SPIE 2024

Narrow linewidth VECSELs for Ba+ cooling at 493 nm

Kostiantyn Nechay, Andreas Schramm, Mika Mähönen, Soile Talmila, Jussi Hämelahti, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa
January 31, 2024
Narrow linewidth 935 nm DBR laser diode for quantum applications
OPTO SPIE 2024

Narrow linewidth 935 nm DBR laser diode for quantum applications

Mika Mähönen, Riina Ulkuniemi, Luukas Kuusela, Timo Aho, Andreas Schramm, Soile Talmila, Pekko Sipilä, Petteri Uusimaa
January 31, 2024
Narrow linewidth DBR and MOPA laser systems for quantum applications in the 7xx nm regime
OPTO SPIE 2024

Narrow linewidth DBR and MOPA laser systems for quantum applications in the 7xx nm regime

Luukas Kuusela, Timo Aho, Riina Ulkuniemi, Mika Mähönen, Jussi Hämelahti, Andreas Schramm, Soile Talmila, Pekko Sipilä, Petteri Uusimaa
January 31, 2024
High brightness long lifetime 650nm single-mode laser diodes and arrays for display, printing, and quantum applications
LASE SPIE 2024

High brightness long lifetime 650nm single-mode laser diodes and arrays for display, printing, and quantum applications

Riina Ulkuniemi, Andreas Schramm, Ville Vilokkinen, Jari Nikkinen, Petteri Uusimaa
January 30, 2024
Tailorable semiconductor laser platform in the 7xx nm regime
LASE SPIE 2024

Tailorable semiconductor laser platform in the 7xx nm regime

Andreas Schramm, Luukas Kuusela, Mika Mähönen, Soile Talmila, Ville Vilokkinen, Petteri Uusimaa
January 29, 2024
Hyperspectral imaging for flow cytometry
SPIE BIOS 2024

Hyperspectral imaging for flow cytometry

Anna Filipchuk, Robert Perttilä, Ana Colucci, Petteri Uusimaa
January 28, 2024
High-power VECSEL with intracavity UV generation for flow cytometry applications
SPIE BIOS 2024

High-power VECSEL with intracavity UV generation for flow cytometry applications

Kostiantyn Nechay, Robert Perttilä, Anna Essaulova, Petteri Uusimaa
January 28, 2024
Fluorescence-guided photoimmunotherapy for peritoneal carcinomatosis
SPIE BIOS 2024

Fluorescence-guided photoimmunotherapy for peritoneal carcinomatosis

Barry Liang, Sumiao Pang, Robert Perttilä, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Nada Fadul, Idrisa Rahman, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang
January 28, 2024
Automated drug detection and dynamic measurement prioritization with medical laser platform
SPIE BIOS 2024

Automated drug detection and dynamic measurement prioritization with medical laser platform

Henri Auvinen, Lassi Luokkanen, Zoe Ylöniemi, Natalia Leinonen, Ana Colucci, Petteri Uusimaa
January 27, 2024
Red-Light Activation of a Microtubule Polymerization Inhibitor via Amide Functionalization of the Ruthenium Photocage
Angew Chem Int Ed

Red-Light Activation of a Microtubule Polymerization Inhibitor via Amide Functionalization of the Ruthenium Photocage

Ludovic Bretin, Yurii Husiev, Vadde Ramu, Liyan Zhang, Matthijs Hakkennes, Selda Abyar, Andrew C. Johns, Sylvia E. Le Dévédec, Tania Betancourt, Alexander Kornienko, Sylvestre Bonnet
December 7, 2023
Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development
Cell Chemical Biology

Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development

Dave L. Carlson, Mark Kowalewski, Khaldon Bodoor, Matthew R. Redinbo, Neil Spector, Timothy A.J. Haystead
November 1, 2023
Development of Robust Cationic Light-Activated Thermosensitive Liposomes: Choosing the Right Lipids
Molecular Pharmaceutics

Development of Robust Cationic Light-Activated Thermosensitive Liposomes: Choosing the Right Lipids

Puja Gangurde, Mohammad Mahmoudzadeh, Zahra Gounani, Artturi Koivuniemi, Patrick Laurén, Tatu Lajunen, Timo Laaksonen
October 24, 2023
Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses
Nature Protocols

Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses

Tadayuki Iwase, Kimihiro Ito, Takashi Nishimura, Kei Miyakawa, Akihide Ryo, Hisataka Kobayashi, Makoto Mitsunaga
October 4, 2023
Fluorescence-guided photoimmunotherapy using targeted nanotechnology and ML7710 to manage peritoneal carcinomatosis
Science Advances

Fluorescence-guided photoimmunotherapy using targeted nanotechnology and ML7710 to manage peritoneal carcinomatosis

Barry J. Liang, Sumiao Pang, Robert Perttilä, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron J. Sorrin, Nada Fadul, Zoe Ylöniemi, Dana M. Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang
September 6, 2023
Photodynamic Therapy of an Abdominal Abscess at the Time of Percutaneous Drainage
CardioVascular and Interventional Radiology

Photodynamic Therapy of an Abdominal Abscess at the Time of Percutaneous Drainage

Timothy M. Baran, Ashwani Kumar Sharma
July 18, 2023
Intratumoral interleukin-15 improves efficacy of near-infrared photoimmunotherapy
Molecular Cancer Therapeutics

Intratumoral interleukin-15 improves efficacy of near-infrared photoimmunotherapy

Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Hiroaki Wakiyama, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi
July 18, 2023
Transient fluid flow improves photoimmunoconjugate delivery and photoimmunotherapy efficacy
iScience

Transient fluid flow improves photoimmunoconjugate delivery and photoimmunotherapy efficacy

Aaron J. Sorrin, Keri Zhou, Katherine May, Cindy Liu, Kathryn McNaughton, Idrisa Rahman, Barry J. Liang, Imran Rizvi, Dana M. Roque, Huang-Chiao Huang
June 26, 2023
Immune checkpoint inhibition combined with targeted therapy using a novel virus‑like drug conjugate induces complete responses in a murine model of local and distant tumors
Cancer Immunology, Immunotherapy

Immune checkpoint inhibition combined with targeted therapy using a novel virus‑like drug conjugate induces complete responses in a murine model of local and distant tumors

Ruben V. Huis in ‘t Veld, Sen Ma, Rhonda C. Kines, Anneli Savinainen, Cadmus Rich, Ferry Ossendorp, Martine J. Jager
March 30, 2023
Fluorescence-guided, targeted photochemotherapy of peritoneal carcinomatosis
SPIE BIOS 2023

Fluorescence-guided, targeted photochemotherapy of peritoneal carcinomatosis

Barry J. Liang, Robert Perttilä, Sumiao Pang, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron J. Sorrin, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang
March 17, 2023
Novel ophthalmic laser system paired with focal electroretinography for subthreshold laser therapy of DME
SPIE BIOS 2023

Novel ophthalmic laser system paired with focal electroretinography for subthreshold laser therapy of DME

Jukka-Pekka Alanko, Eero Koivumäki, Laura Vesala, Johannes Kivelä, Zoe Ylöniemi, Petteri Uusimaa, Ossi Kaikkonen, Teemu Turunen, Jaakko Nieminen, Jani Tirronen
March 17, 2023
Output beam engineering with 2-step ridge etching
SPIE OPTO 2023

Output beam engineering with 2-step ridge etching

Riina Ulkuniemi, Ville Vilokkinen, Petri Melanen, Petteri Uusimaa
March 17, 2023
Laser platform and light delivery optimization for bladder cancer treatment with a novel photosensitive drug
SPIE BIOS 2023

Laser platform and light delivery optimization for bladder cancer treatment with a novel photosensitive drug

Zoe Ylöniemi, Elias Kokko, Visa Kaivosoja, Ana Colucci, Eerika Suokas, Jukka-Pekka Alanko, Petteri Uusimaa, Modulight Corp.
March 14, 2023
Novel ophthalmic PDT laser platform to target oncology and various other retinal indications
SPIE BIOS 2023

Novel ophthalmic PDT laser platform to target oncology and various other retinal indications

Laura Vesala, Eero Koivumäki, Jukka-Pekka Alanko, Timo Tanila, Ivan Baldin, Zoe Ylöniemi, Petteri Uusimaa, Modulight Corp.
March 14, 2023
Optimization of light delivery for non-muscle invasive bladder cancer PDT
SPIE BIOS 2023

Optimization of light delivery for non-muscle invasive bladder cancer PDT

Elias Kokko, Robert Perttilä, Zoe Ylöniemi, Visa Kaivosoja, Jukka-Pekka Alanko, Petteri Uusimaa, Modulight Corp.
March 14, 2023
Configurable multiwavelength narrow linewidth laser system for quantum applications
SPIE Quantum West 2023

Configurable multiwavelength narrow linewidth laser system for quantum applications

Kostiantyn Nechay, Luukas Kuusela, Ossi Mäkinen, Riina Ulkuniemi, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa
March 8, 2023
Optimization and fabrication of 780 nm DFB lasers for quantum systems
SPIE Quantum West 2023

Optimization and fabrication of 780 nm DFB lasers for quantum systems

Riina Ulkuniemi, Luukas Kuusela, Timo Aho, Petteri Uusimaa
March 8, 2023
High aspect ratio DBR gratings for narrow linewidth red lasers
SPIE Quantum West 2023

High aspect ratio DBR gratings for narrow linewidth red lasers

Luukas Kuusela, Riina Ulkuniemi, Timo Aho, Petteri Uusimaa
March 8, 2023
Light-induced cytotoxicity in cells utilizing an automated well plate illuminator
SPIE BIOS 2023

Light-induced cytotoxicity in cells utilizing an automated well plate illuminator

Laura Vesala, Robert Perttilä, Elias Kokko, Johannes Kivelä, Lasse Orsila, Petteri Uusimaa
March 7, 2023
Selective depletion of polymorphonuclear myeloid derived suppressor cells in tumor beds with near infrared photoimmunotherapy enhances host immune response
OncoImmunology

Selective depletion of polymorphonuclear myeloid derived suppressor cells in tumor beds with near infrared photoimmunotherapy enhances host immune response

Takuya Kato, Hiroshi Fukushima, Aki Furusawa, Ryuhei Okada, Hiroaki Wakiyama, Hideyuki Furumoto, Shuhei Okuyama, Seiichiro Takao, Peter L. Choyke, Hisataka Kobayashi
November 30, 2022
A Non-Invasive Deep Photoablation Technique to Inhibit DCIS Progression and Induce Antitumor Immunity
Cancers

A Non-Invasive Deep Photoablation Technique to Inhibit DCIS Progression and Induce Antitumor Immunity

Kensuke Kaneko, Hiroshi Nagata, Xiao-Yi Yang, Joshua Ginzel, Zachary Hartman, Jeffrey Everitt, Philip Hughes, Timothy Haystead, Michael Morse, Herbert Kim Lyerly, Takuya Osada
November 23, 2022
Treg-Dominant Tumor Microenvironment Is Responsible for Hyperprogressive Disease after PD-1 Blockade Therapy
Cancer Immunology Research

Treg-Dominant Tumor Microenvironment Is Responsible for Hyperprogressive Disease after PD-1 Blockade Therapy

Hiroaki Wakiyama, Takuya Kato, Aki Furusawa, Ryuhei Okada, Fuyuki Inagaki, Hideyuki Furumoto, Hiroshi Fukushima, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi
November 2, 2022
Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers
Journal for ImmunoTherapy of Cancer

Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers

Kensuke Kaneko, Chaitanya R Acharya, Hiroshi Nagata, Xiao Yang, Zachary Conrad Hartman, Amy Hobeika, Philip F Hughes, Timothy A J Haystead, Michael A Morse, Herbert Kim Lyerly, Takuya Osada
September 28, 2022
Pharmaceutical nanotechnology applied to phthalocyanines for the promotion of antimicrobial photodynamic therapy: A literature review
Photodiagnosis and Photodynamic Therapy

Pharmaceutical nanotechnology applied to phthalocyanines for the promotion of antimicrobial photodynamic therapy: A literature review

Luciana Betzler de Oliveira de Siqueira, Ana Paula dos Santos Matos, Marcio Robert Mattos da Silva, Suvene Rocha Pinto, Ralph Santos-Oliveira, Eduardo Ricci-Júnior
September 1, 2022
Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW
Frontiers in Oncology

Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW

Chanda Bhandari, John Fakhry, Menitte Eroy, Jane Junghwa Song, Kimberley Samkoe, Tayyaba Hasan, Kenneth Hoyt, Girgis Obaid
June 28, 2022
Cyanine Phototruncation Enables Spatiotemporal Cell Labeling
Journal of the American Chemical Society

Cyanine Phototruncation Enables Spatiotemporal Cell Labeling

Hiroshi Fukushima, Siddharth S. Matikonda, Syed Muhammad Usama, Aki Furusawa, Takuya Kato, Lenka Štacková, Petr Klán, Hisataka Kobayashi, Martin J. Schnermann
June 13, 2022
Ophthalmic laser platform utilizing AI to enhance treatment planning of liposomal drug release
BIOS 2022

Ophthalmic laser platform utilizing AI to enhance treatment planning of liposomal drug release

Eero Koivumäki, Laura Vesala, Jukka-Pekka Alanko, Timo Tanila, Petteri Uusimaa, Modulight Corporation
March 7, 2022
Laser illumination platform with real-time spectral monitoring and treatment
SPIE BIOS 2022

Laser illumination platform with real-time spectral monitoring and treatment

Visa Kaivosoja, Robert Perttilä, Elias Kokko, Timo Tanila, Zoe Ylöniemi, Petteri Uusimaa, Modulight Corporation (Finland)
March 7, 2022
Thermal management optimization in high-power 3D sensing VCSELs
LASE SPIE 2022

Thermal management optimization in high-power 3D sensing VCSELs

A. Filipchuk, K. Nechay, R. Ulkuniemi, S. Talmila, P. Uusimaa
March 4, 2022
High-power individually addressable visible and MID-IR laser arrays for display and other applications
LASE SPIE 2022

High-power individually addressable visible and MID-IR laser arrays for display and other applications

Riina Ulkuniemi, Ilpo Suominen, Ville Vilokkinen, Jari Sillanpää, Petteri Uusimaa
March 4, 2022
Light-activated drug release using an automated well plate illuminator
BIOS 2022

Light-activated drug release using an automated well plate illuminator

Laura Vesala, Robert Perttilä, Elias Kokko, Lasse Orsila, Modulight Corporation (Finland), Tampere Univ. Hospital (Finland); Petteri Uusimaa, Modulight Corporation (Finland)
March 4, 2022
Theranostic laser system for multi-function drug activation and monitoring
BIOS 2022

Theranostic laser system for multi-function drug activation and monitoring

Robert Perttilä, Visa Kaivosoja, Elias Kokko, Zoe Ylöniemi, Lasse Orsila, Modulight Corporation (Finland), Tampere Univ. Hospital (Finland); Timo Tanila, Petteri Uusimaa, Modulight Corporation (Finland)
March 3, 2022
Configurable multi-wavelength laser light engine for endoscopic fluorescence imaging
BIOS 2022

Configurable multi-wavelength laser light engine for endoscopic fluorescence imaging

Zoe Ylöniemi, Visa Kaivosoja, Lasse Orsila, Tero Vierimaa, Petteri Uusimaa, Modulight Corporation
March 3, 2022
High-density single-mode laser arrays for quantum systems
OPTO 2022

High-density single-mode laser arrays for quantum systems

Riina Ulkuniemi, Petri Melanen, Jari Nikkinen, Jari Ovaskainen, Petteri Uusimaa
March 1, 2022
Antitumor Effect and Induced Immune Response Following Exposure of Hexaminolevulinate and Blue Light in Combination with Checkpoint Inhibitor in an Orthotopic Model of Rat Bladder Cancer
Biomedicines

Antitumor Effect and Induced Immune Response Following Exposure of Hexaminolevulinate and Blue Light in Combination with Checkpoint Inhibitor in an Orthotopic Model of Rat Bladder Cancer

Laureline Lamy, Jacques Thomas, Agnès Leroux, Jean-François Bisson, Kari Myren, Aslak Godal, Gry Stensrud, Lina Bezdetnaya
February 25, 2022
CD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a pigmented melanoma model
OncoImmunology

CD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a pigmented melanoma model

Aki Furusawa, Ryuhei Okada, Fuyuki Inagaki, Hiroaki Wakiyama, Takuya Kato, Hideyuki Furumoto, Hiroshi Fukushima, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi
January 4, 2022
Nanobody-targeted photodynamic therapy for the treatment of feline oral carcinoma: a step towards translation to the veterinary clinic
Nanophotonics

Nanobody-targeted photodynamic therapy for the treatment of feline oral carcinoma: a step towards translation to the veterinary clinic

Irati Beltrán Hernández, Guillaume C.M. Grinwis, Alessia Di Maggio, Paul M.P. van Bergen en Henegouwen, Wim E. Hennink, Erik Teske, Jan W. Hesselink, Sebastiaan A. van Nimwegen, Jan A. Mol, Sabrina Oliveira
August 2, 2021
Rapid Depletion of Intratumoral Regulatory T cells Induces Synchronized CD8 T and NK Cell Activation and IFN-γ-dependent Tumor Vessel Regression
Cancer Research

Rapid Depletion of Intratumoral Regulatory T cells Induces Synchronized CD8 T and NK Cell Activation and IFN-γ-dependent Tumor Vessel Regression

Yutaka Kurebayashi, Colleen P. Olkowski, Kelly C. Lane, Olga V. Vasalatiy, Biying C. Xu, Ryuhei Okada, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi, Noriko Sato
June 1, 2021
Virus-like particle-drug conjugates induce protective, long-lasting adaptive anti-tumor immunity in the absence of specifically targeted tumor antigens
Cancer Immunology Research

Virus-like particle-drug conjugates induce protective, long-lasting adaptive anti-tumor immunity in the absence of specifically targeted tumor antigens

Rhonda C Kines, Cynthia D Thompson, Sean Spring, Zhenyu Li, Elisabet de los Pinos, Stephen Monks, John T Schiller
June 1, 2021
Eye-safe laser illuminators for long-reach LIDAR and gated imaging in harsh weather conditions
LASE 2021

Eye-safe laser illuminators for long-reach LIDAR and gated imaging in harsh weather conditions

Lasse Orsila, Visa Kaivosoja, Petri Melanen, Petteri Uusimaa
March 5, 2021
Medical laser platform to induce and monitor drug release from nano-constructs in vitro and in vivo
BIOS 2021

Medical laser platform to induce and monitor drug release from nano-constructs in vitro and in vivo

Zoe Ylöniemi, Johannes Kivelä, Elias Kokko, Robert Perttilä, Visa Kaivosoja, Lasse Orsila, Petteri Uusimaa
March 5, 2021
Cloud-based medical laser platform for phototherapy and treatment monitoring for glioblastoma
BIOS 2021

Cloud-based medical laser platform for phototherapy and treatment monitoring for glioblastoma

Zoe Ylöniemi, Visa Kaivosoja, Juha Lemmetti, Timo Tanila, Eero Koivumäki, Lasse Orsila, Petteri Uusimaa
March 5, 2021
High temperature AlGaInAs-based 25g DML-DFB lasers operating in O-band for data center use
OPTO 2021

High temperature AlGaInAs-based 25g DML-DFB lasers operating in O-band for data center use

Antti Saarela, Petri Melanen, Ville Vilokkinen, Luukas Kuusela, Petteri Uusimaa, Pekko Sipilä, Riina Ulkuniemi, Ossi Mäkinen
March 5, 2021
Towards high-throughput light-activated drug discovery using automated plate illuminator
BIOS 2021

Towards high-throughput light-activated drug discovery using automated plate illuminator

Robert Perttilä, John Roque III, Lasse Orsila, Zoe Ylöniemi, Elias Kokko, Colin G. Cameron, Sherri A. McFarland, Petteri Uusimaa
March 5, 2021
Long-range all-solid-state flash LiDAR sensor for autonomous driving
LASE 2021

Long-range all-solid-state flash LiDAR sensor for autonomous driving

Juha Lemmetti, Niklas Sorri, Ilkka Kallioniemi, Petri Melanen, Petteri Uusimaa
March 5, 2021
Configurable cloud based medical laser platform with real-time treatment monitoring
BIOS 2021

Configurable cloud based medical laser platform with real-time treatment monitoring

Visa Kaivosoja, Zoe Ylöniemi, Juha Lemmetti, Timo Tanila, Lasse Orsila, Petteri Uusimaa, Modulight, Inc. (Finland)
March 5, 2021
High-efficiency vertically-emitting chipsets for 3D and proximity sensing
LASE 2021

High-efficiency vertically-emitting chipsets for 3D and proximity sensing

K. Nechay, R. Ulkuniemi, A. Filipchuk, T. Hartikainen, V. Kaivosoja, R. Hietikko, J. Nikkinen, J. Sillanpaa, P. Melanen, V. Vilokkinen, S. Talmila, P. Uusimaa
March 5, 2021
Configurable automated well plate illuminator for in vitro research in drug discovery and optogenetics
BIOS 2021

Configurable automated well plate illuminator for in vitro research in drug discovery and optogenetics

Elias Kokko, Robert Perttilä, Lasse Orsila, Zoe Ylöniemi, Johannes Kivelä, Petteri Uusimaa
March 5, 2021
Configurable cloud-connected iPad controlled multimodal ophthalmic laser
BIOS 2021

Configurable cloud-connected iPad controlled multimodal ophthalmic laser

Jukka-Pekka Alanko, Visa Kaivosoja, Ivan Baldin, Timo Tanila, Eero Koivumäki, Petteri Uusimaa, Zoe Ylöniemi, Modulight, Inc. (Finland)
March 5, 2021
Individually addressable visible laser arrays for display and printing applications
LASE 2021

Individually addressable visible laser arrays for display and printing applications

Riina Ulkuniemi, Ville Vilokkinen, Ilpo Suominen, Soile Talmila, Jari Sillanpää, Petteri Uusimaa
March 5, 2021
High-efficiency and reliable pump lasers for fiber lasers
LASE 2021

High-efficiency and reliable pump lasers for fiber lasers

Jari Nikkinen, Soile Talmila, Ville Vilokkinen, Petri Melanen, Antti Saarela, Lasse Orsila, Jari Sillanpää, Petteri Uusimaa, Seppo Orsila
March 5, 2021
Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers
Frontiers in Immunology

Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers

Tone Otterhaug, Sylvia Janetzki, Marij J. P. Welters, Monika Håkerud, Anne Grete Nedberg, Victoria Tudor Edwards, Sanne Boekestijn, Nikki M. Loof, Pål Kristian Selbo, Hans Olivecrona, Sjoerd H. van der Burg, Anders Høgset
January 8, 2021
Theranostic Prospects of Graphene Quantum Dots in Breast Cancer
ACS Biomaterials Science and Engineering

Theranostic Prospects of Graphene Quantum Dots in Breast Cancer

Rahul S. Tade, Pravin O. Patil
October 26, 2020
Near-infrared Absorbing Ru(II) Complexes Act as Immunoprotective Photodynamic Therapy (PDT) Agents Against Aggressive Melanoma
Chemical Science

Near-infrared Absorbing Ru(II) Complexes Act as Immunoprotective Photodynamic Therapy (PDT) Agents Against Aggressive Melanoma

Liubov M. Lifshits, A. Roque III, Prathyusha Konda, Susan Monro, Houston D. Cole, David von Dohlen, Susy Kim, Gagan Deep, Randolph P. Thummel, Colin G. Cameron, Shashi Gujar, Sherri A. McFarland
September 9, 2020
Breaking the barrier: an osmium photosensitizer with unprecedented hypoxic phototoxicity for real world photodynamic therapy
Chemical Science

Breaking the barrier: an osmium photosensitizer with unprecedented hypoxic phototoxicity for real world photodynamic therapy

John A. Roque III, Patrick C. Barrett, Houston D. Cole, Liubov M. Lifshits, Ge Shi, Susan Monro, David von Dohlen, Susy Kim, Nino Russo, Gagan Deep, Colin G. Cameron, Marta E. Alberto, Sherri A. McFarland
August 3, 2020
Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors
Communications Biology

Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors

Kensuke Kaneko, Takuya Osada, Michael A. Morse, William R. Gwin, Joshua D. Ginzel, Joshua C. Snyder, Xiao-Yi Yang, Cong-Xiao Liu, Márcio A. Diniz, Khaldon Bodoor, Philip F. Hughes, Timothy AJ. Haystead, H. Kim Lyerly
May 8, 2020
High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies
Nature Biomedical Engineering

High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies

Katja Haedicke, Lilach Agemy, Murad Omar, Andrei Berezhnoi, Sheryl Roberts, Camila Longo-Machado, Magdalena Skubal, Karan Nagar, Hsiao-Ting Hsu, Kwanghee Kim, Thomas Reiner, Jonathan Coleman, Vasilis Ntziachristos, Avigdor Scherz, Jan Grimm
March 12, 2020
Light Sources and Dosimetry Techniques for Photodynamic Therapy
Photochemistry and Photobiology

Light Sources and Dosimetry Techniques for Photodynamic Therapy

Michele M. Kim, Arash Darafsheh
January 31, 2020
Combination of ALA-induced fluorescence-guided resection and intraoperative open photodynamic therapy for recurrent glioblastoma: case series on a promising dual strategy for local tumor control
Journal of Neurosurgery

Combination of ALA-induced fluorescence-guided resection and intraoperative open photodynamic therapy for recurrent glioblastoma: case series on a promising dual strategy for local tumor control

Stephanie Schipmann, Michael Müther, Louise Stögbauer, Sebastian Zimmer, Benjamin Brokinkel, Markus Holling, Oliver Grauer, Eric Suero Molina, Nils Warneke, Walter Stummer
January 24, 2020
Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging
Theranostics

Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging

Henriette S. de Bruijn, Vida Mashayekhi, Tom J.L. Schreurs, Pieter B.A.A. van Driel, Gustav J. Strijkers, Paul J. van Diest, Clemens W.G.M. Lowik, Ann L.B. Seynhaeve, Timo L.M. ten Hagen, Jeanine J. Prompers, Paul M.P. van Bergen en Henegouwen, Dominic J. Robinson, Sabrina Oliveira
January 20, 2020
Breaking the selectivity‑uptake trade‑off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi‑tier cancer targeting
Journal of Nanobiotechnology

Breaking the selectivity‑uptake trade‑off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi‑tier cancer targeting

Barry J. Liang, Michael Pigula, Yan Baglo, Daniel Najafali , Tayyaba Hasan, Huang‑Chiao Huang
January 2, 2020
Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells
Cancer Letters

Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells

Yan Baglo, Barry J. Liang, Robert W. Robey, Suresh V. Ambudkar, Michael M. Gottesman, Huang-Chiao Huang
August 10, 2019
Effects and side-effects of plasmonic photothermal therapy in brain tissue
Cancer Nanotechnology

Effects and side-effects of plasmonic photothermal therapy in brain tissue

Yue He, Kristoffer Laugesen, Dana Kamp, Salik Ahmad Sultan, Lene Broeng Oddershede, Liselotte Jauffred
February 18, 2019
Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels
Materials Science & Engineering C

Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels

Kaisa Vuornos, Miina Ojansivu, Janne T. Koivisto, Heikki Häkkänen, Birhanu Belay, Toni Montonen, Heini Huhtala, Minna Kääräinen, Leena Hupa, Minna Kellomäki, Jari Hyttinen, Janne A. Ihalainen, Susanna Miettinen
February 13, 2019
Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer
British Journal of Cancer

Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer

Gal Shafirstein, David A. Bellnier, Emily Oakley, Sasheen Hamilton, Michael Habitzruther, Lawrence Tworek, Alan Hutson, Joseph A. Spernyak, Sandra Sexton, Leslie Curtin, Steven G. Turowski, Hassan Arshad, Barbara Henderson
October 24, 2018
The effect of light sensitizer localization on the stability of indocyanine green liposomes
Journal of Controlled Release

The effect of light sensitizer localization on the stability of indocyanine green liposomes

Tatu Lajunen, Riikka Nurmi, Danny Wilbie, Teemu Ruoslahti, Niklas G. Johansson, Ossi Korhonen, Tomasz Rog, Alex Bunker, Marika Ruponen, Arto Urtti
August 28, 2018
Platinum nanoparticles: a non-toxic, effective and thermally stable alternative plasmonic material for cancer therapy and bioengineering
Nanoscale

Platinum nanoparticles: a non-toxic, effective and thermally stable alternative plasmonic material for cancer therapy and bioengineering

Akbar Samadi, Henrik Klingberg, Liselotte Jauffred, Andreas Kjær, Poul Martin Bendix, Lene B. Oddershede
April 25, 2018
An Infrared Dye–Conjugated Virus-like Particle for the Treatment of Primary Uveal Melanoma
Molecular Cancer Therapeutics

An Infrared Dye–Conjugated Virus-like Particle for the Treatment of Primary Uveal Melanoma

Rhonda C. Kines, Isabella Varsavsky, Sanghamitra Choudhary, Debaditya Bhattacharya, Sean Spring, Roger McLaughlin, Shin J. Kang, Hans E. Grossniklaus, Demetrios Vavvas, Stephen Monks, John R. MacDougall, Elisabet de los Pinos, and John T. Schiller
February 1, 2018
WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice
Theranostics

WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice

Volker Neuschmelting, Kwanghee Kim, Jaber Malekzadeh-Najafabadi, Sylvia Jebiwott, Jaya Prakash, Avigdor Scherz, Jonathan A. Coleman, Moritz F. Kircher, Vasilis Ntziachristos
January 1, 2018
Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation
Cardiovascular therapeutics

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation

Manish Jain, Matthieu Zellweger, Georges Wagnières, Hubert van den Bergh, Stéphane Cook, Marie-Noelle Giraud
November 28, 2016
Fast quantitative ROS detection based on dual-color single rare-earth nanoparticle imaging reveals signaling pathway kinetics in living cells
Nanoscale

Fast quantitative ROS detection based on dual-color single rare-earth nanoparticle imaging reveals signaling pathway kinetics in living cells

M. Abdesselem, R. Ramodiharilafy, L. Devys, T. Gacoin, A. Alexandrou, C. I. Bouzigues
November 28, 2016
Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial
Lancet Oncology

Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial

Ahmed A Sultan, Waseem Jerjes, Kristian Berg, Anders Høgset, Charles A Mosse, Rifat Hamoudi, Zaid Hamdoon, Celia Simeon, Dawn Carnell, Martin Forster, Colin Hopper
July 27, 2016
EGFR targeted nanobody–photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer
Journal of Controlled Release

EGFR targeted nanobody–photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer

Pieter B.A.A. van Driel, Martin C. Boonstra, Maxime D. Slooter, Raimond Heukers, Marieke A. Stammes, Thomas J.A. Snoeks, Henriette S. de Bruijn, Paul J. van Diest, Alexander L. Vahrmeijer, Paul M.P. van Bergen en Henegouwen, Cornelis J.H. van de Velde, Clemens W.G.M. Löwik, Dominic J. Robinson, Sabrina Oliveira
May 10, 2016
Photodynamic Therapy of Non–Small Cell Lung Cancer. Narrative Review and Future Directions
Annals of the American Thoracic Society

Photodynamic Therapy of Non–Small Cell Lung Cancer. Narrative Review and Future Directions

Gal Shafirstein, Athar Battoo, Kassem Harris, Heinz Baumann, Sandra O. Gollnick, Joerg Lindenmann, and Chukwumere E. Nwogu
February 1, 2016
Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met
Nature Medicine

Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met

Jacobus Burggraaf, Ingrid M C Kamerling, Paul B Gordon, Lenneke Schrier, Marieke L de Kam, Andrea J Kales, Ragnar Bendiksen, Bård Indrevoll, Roger M Bjerke, Siver A Moestue, Siavash Yazdanfar, Alexandra M J Langers, Marit Swaerd-Nordmo, Geir Torheim, Madhuri V Warren, Hans Morreau, Philip W Voorneveld, Tessa Buckle, Fijs W B van Leeuwen, Liv-Ingrid Ødegårdstuen, Grethe T Dalsgaard, Andrew Healey, James C H Hardwick
July 13, 2015