Photodynamic Therapy of Non–Small Cell Lung Cancer. Narrative Review and Future Directions

Published in: Annals of the American Thoracic Society

Authors: Gal Shafirstein 1,2Athar Battoo 3Kassem Harris 4Heinz Baumann 5Sandra O. Gollnick 1,6Joerg Lindenmann 1,7, and Chukwumere E. Nwogu 3

1Photodynamic Therapy Center

2Department of Cell Stress Biology

3Department of Thoracic Surgery

4Department of Medicine, Interventional Pulmonology

5Department of Molecular and Cellular Biology, and

6Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York; and

7Division of Thoracic and Hyperbaric Surgery, Medical University Graz, Graz, Austria

Corresponding Author: Gal Shafirstein



The paper describes the history of lung cancer PDT and results from relevant studies. ML7710 was used by Roswell Park in a clinical study for intraoperative PDT with temoporfin to treat patients with resectable non-small cell lung cancer (NCT01854684). PDT was coupled with resection to eliminate the microscopic cells that are often associated with disease recurrence. A balloon light applicator was used for light delivery, and light dose was monitored with dosimetry system in 8 locations within thoracic cavity.


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