Published in: Annals of the American Thoracic Society
Authors: Gal Shafirstein 1,2, Athar Battoo 3, Kassem Harris 4, Heinz Baumann 5, Sandra O. Gollnick 1,6, Joerg Lindenmann 1,7, and Chukwumere E. Nwogu 3
1Photodynamic Therapy Center
2Department of Cell Stress Biology
3Department of Thoracic Surgery
4Department of Medicine, Interventional Pulmonology
5Department of Molecular and Cellular Biology, and
6Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York; and
7Division of Thoracic and Hyperbaric Surgery, Medical University Graz, Graz, Austria
The paper describes the history of lung cancer PDT and results from relevant studies. ML7710 was used by Roswell Park in a clinical study for intraoperative PDT with temoporfin to treat patients with resectable non-small cell lung cancer (NCT01854684). PDT was coupled with resection to eliminate the microscopic cells that are often associated with disease recurrence. A balloon light applicator was used for light delivery, and light dose was monitored with dosimetry system in 8 locations within thoracic cavity.
