Tag Archives: Lung cancer

ML7710 for photoactivated treatment of lung cancer

Deadliest cancer Precision with photoactivation Photoimmunotherapy with ML7710 offers a clinical therapeutic option for NSCLC patients even with advanced disease stage. Besides laser light, this therapy involves photoactivated drug, which can be activated precisely at the tumor site with laser fibers, hence minimizing drug effects to healthy tissues. Smaller invasiveness compared to surgery can enable patients to stay less time recovering at the hospital. It can also be repeated if needed multiple times without cumulating toxicities, unlike radiation therapy. Some previously inoperable tumors can decrease Continue reading →Deadliest cancer Lung cancer is the leading cause of cancer deaths worldwide, with more than 2.2 million cases and 1.8 million deaths each year [1]. Lung cancer can be divided into two types, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), with the latter accounting for about 85% of all lung cancer cases. NSCL is usually less sensitive to chemo- and radiotherapy and in many cases tumor cannot be removed surgically or has spread from lungs to distant sites at the time Continue reading →

Fluorescence imaging & endoscopy for tumor visualization and diagnostics

Several fluorescent agents have been approved for fluorescence based diagnosis & intraoperative imaging: Dye generic name Countries Excitation Detection Indications Indocyanine Green (ICG) Worldwide 800 nm Near-infrared (820 nm) Multiple uses: lymphatic mapping, tissue perfusion, visualization of biliary ducts and blood veins, retinal angiography Fluorescein Worldwide 490 nm Green fluorescence (525 nm) Fluorescein angiography or angioscopy (ophthalmology) Methylene Blue Worldwide 665 nm 688 nm Endoscopic polypectomy, chromoendoscopy, lymphatic drainage 5-ALA Hydrochloride (converted to Pp-IX) Worldwide 400 – 410 nm Red fluorescence (620 – 710 nm) Continue reading →Introduction to fluorescence imaging Fluorescence is a phenomenon where substance that has absorbed certain wavelength of light emits it back at another wavelength. These substances are called fluorophores or fluorescent dyes. The emitted light has a longer wavelength than the absorbed one since some energy of the photon is lost in the process. The difference in wavelengths between absorbed and emitted light, called Stokes shift, allows very low background for fluorescence detection by separating it from the excitation light. The process of fluorescence generation is Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – June 2021

Modulight Spotlights: LASER-SHARP RESEARCH – June 2021 The findings by Prof. Lothar Lilge and his team might enable improved treatment of diffuse lung metastasis which are difficult to treat with standard therapies. A novel lung perfusion platform significantly reduced tissue absorption and allowed better light penetration, resulting in up to 3-fold increased treatment volumes.   Read original publication   Modulight is very happy to be supporting this research. We would like to deliver our warmest congratulations to the research team!   #LaserSharpResearch  #ModulightInScience   #LasersInScience Continue reading →

Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer

Published in: British Journal of Cancer Authors: Gal Shafirstein, David A. Bellnier, Emily Oakley, Sasheen Hamilton, Michael Habitzruther, Lawrence Tworek, Alan Hutson, Joseph A. Spernyak, Sandra Sexton, Leslie Curtin, Steven G. Turowski, Hassan Arshad, Barbara Henderson    Published in: British Journal of Cancer Authors: Gal Shafirstein, David A. Bellnier, Emily Oakley, Sasheen Hamilton, Michael Habitzruther, Lawrence Tworek, Alan Hutson, Joseph A. Spernyak, Sandra Sexton, Leslie Curtin, Steven G. Turowski, Hassan Arshad, Barbara Henderson   Currently delivered light dose (J/cm2) is the principal parameter guiding interstitial photodynamic therapy (I-PDT) of refractory locally advanced cancer. The aim of this study was to investigate the impact of light dose rate (irradiance, mW/cm2) and associated heating on tumour response and cure. Laser was used to activate Continue reading →

ML7710 for lung cancer treatments at Roswell Park

Treating lung cancer has been a huge challenge, but now, a treatment that’s been around for decades is being used in a new way, and the results so far have been encouraging. In this video thoraic surgeon Dr. Nwogu at Roswell  Park Comprehensive Cancer Center explains the benefits of PDT treatment for lung cancer. A patient, George Grace, tells how being in this clinical trial  saved his life. ML7710 laser system is shown on the video and has been in use for lung cancer treatments Continue reading →Treating lung cancer has been a huge challenge, but now, a treatment that’s been around for decades is being used in a new way, and the results so far have been encouraging. In this video thoraic surgeon Dr. Nwogu at Roswell  Park Comprehensive Cancer Center explains the benefits of PDT treatment for lung cancer. A patient, George Grace, tells how being in this clinical trial  saved his life. ML7710 laser system is shown on the video and has been in use for lung cancer treatments Continue reading →

Photodynamic Therapy of Non–Small Cell Lung Cancer. Narrative Review and Future Directions

Published in: Annals of the American Thoracic Society Authors: Gal Shafirstein 1,2, Athar Battoo 3, Kassem Harris 4, Heinz Baumann 5, Sandra O. Gollnick 1,6, Joerg Lindenmann 1,7, and Chukwumere E. Nwogu 3 1Photodynamic Therapy Center 2Department of Cell Stress Biology 3Department of Thoracic Surgery 4Department of Medicine, Interventional Pulmonology 5Department of Molecular and Cellular Biology, and 6Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York; and 7Division of Thoracic and Hyperbaric Surgery, Medical University Graz, Graz, Austria Corresponding Author: Gal Shafirstein    Published in: Annals of the American Thoracic Society Authors: Gal Shafirstein 1,2, Athar Battoo 3, Kassem Harris 4, Heinz Baumann 5, Sandra O. Gollnick 1,6, Joerg Lindenmann 1,7, and Chukwumere E. Nwogu 3 1Photodynamic Therapy Center 2Department of Cell Stress Biology 3Department of Thoracic Surgery 4Department of Medicine, Interventional Pulmonology 5Department of Molecular and Cellular Biology, and 6Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York; and 7Division of Thoracic and Hyperbaric Surgery, Medical University Graz, Graz, Austria Corresponding Author: Gal Shafirstein     The paper describes the history of lung cancer PDT and results from relevant studies. Continue reading →