Protected: Modulight Spotlights: LASER-SHARP RESEARCH – June 2026
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ML7710
Modulight Spotlights: LASER-SHARP RESEARCH – April 2026
Modulight Spotlights: LASER-SHARP RESEARCH – April 2026 This month we are pleased to highlight new interesting article by Naoya Kondo and the team at Kansai Medical University in Japan. They developed a cancer cell-targeted photoimmunotherapy compound consisting of IR700 photoabsorber conjugated to bicyclic peptide. Use of small peptide could speed drug clearance from the body
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Modulight Spotlights: LASER-SHARP RESEARCH – March 2026
Modulight Spotlights: LASER-SHARP RESEARCH – March 2026 The development of chemoresistance presents a major challenge in treating peritoneal metastasis, which often occurs in advanced ovarian cancer. To tackle this, Kaitlyn Moore and teams at University of Maryland and National Cancer Institute evaluated photoimmunotherapy as a solution to inhibit a drug efflux pump on cancer cells
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Modulight Spotlights: LASER-SHARP RESEARCH – February 2026
Modulight Spotlights: LASER-SHARP RESEARCH – February 2026 This month, we are highlighting promising work by Professor Hirofumi Hanaoka’s team at Kansai Medical University, Photo-ImmunoTherapy Research Institute. They developed a novel peptide-based photoimmunotherapy drug that targets PD-L1, which is expressed on many types of cancer cells. Preclinical experiments showed significant suppression of tumor growth and an
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Modulight Spotlights: LASER-SHARP RESEARCH – October 2025
This month we are highlighting exciting findings by S. Takao et al. from Hisataka Kobayashi’s lab at the National Cancer Institute, NIH. Published in Cancer Letters, the study shows that near-infrared photoimmunotherapy can destroy cancer cells by targeting intercellular adhesion molecule-1.
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Modulight Spotlights: LASER-SHARP RESEARCH – September 2025
Published in journal Cancer Medicine, the study shows that the therapeutic effect of photoimmunotherapy is highly dependent on the used light irradiation conditions. Application of the ML7710 medical laser at different durations and powers resulted in highest anti-tumor effect with increased light dose but lowering fluence rate below what is currently used in clinic.
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Interleukin 15 (IL15)-based near-infrared photoimmunotherapy
Published in: Cancer Immunology, Immunotherapy Authors: Motofumi Suzuki, Aki Furusawa, Hiroshi Yamamoto, Makoto Kano, Miyu Kano, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi
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Modulight Spotlights: LASER-SHARP RESEARCH – August 2025
Laser-sharp research of the month is by Furusawa et al. at Center for Cancer Research, National Cancer Institute, USA. The discovery, published in Annals of Medicine, showed the potential of photoimmunotherapy for treating breast cancer. To expand the usefulness of photoimmunotherapy outside the clinically approved head & neck indication, the new therapy targeted epithelial cell adhesion molecule in breast cancer.
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EpCAM-targeted near-infrared photoimmunotherapy (NIR-PIT) for the treatment of breast cancer
Published in: Annals of Medicine Authors: Aki Furusawa ,Seiichiro Takao, Motofumi Suzuki, Makoto Kano, Hiroshi Yamamoto, Miyu Kano, Peter Choyke, Hisataka Kobayashi