Tag: ML7710

Modulight Spotlights: LASER-SHARP RESEARCH – June 2025

Laser-sharp Research / Cancer therapy, fluorescence, in vitro, in vivo, laser-sharp research, liver cancer, ML7710, pancreas, pancreatic cancer, theranostics, University of Maryland

Chen-Hua Ma et al. Optical Therapeutics & Nanotechnology Laboratory at University of Maryland combined photoimmunotherapy with ethanol ablation to achieve improved drug retention and light penetration, especially important for treating pigmented organs like liver and pancreas. Modulight’s ML7710 laser was used for both therapeutic activation of the nanoconstruct, as well as for theranostic monitoring of the process.

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Synergizing photodynamic therapy and ethanol ablation: Light-activatable sustained-exposure ethanol injection technology for enhanced tumor ablation

Scientific papers / Cancer therapy, fluorescence, in vitro, in vivo, liver cancer, ML7710, pancreas, pancreatic cancer, theranostics, University of Maryland

Published in: Bioengineering & Translational Medicine Authors: Chen-Hua Ma, Jeffrey Yang, John A. Quinlan, Kathryn McNaughton, Michele L. Kaluzienski, Tessa Hauser, Matthew F. Starost, Jenna L. Mueller, Huang-Chiao Huang

Synergizing photodynamic therapy and ethanol ablation: Light-activatable sustained-exposure ethanol injection technology for enhanced tumor ablation Read More »

Impact of Vitamin C on Immune Response and Edema Following Near-Infrared Photoimmunotherapy (NIR-PIT)

Scientific papers / 690 nm, in vitro, in vivo, IR700, IRDye700DX, ML7710, NIR, PDT, Photoimmunotherapy, tumor

Published in: Cancer Science Authors: Hiroshi Yamamoto, Aki Furusawa, Hiroshi Fukushima, Seiichiro Takao, Motofumi Suzuki, Makoto Kano, Miyu Kano, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi

Impact of Vitamin C on Immune Response and Edema Following Near-Infrared Photoimmunotherapy (NIR-PIT) Read More »

Modulight Spotlights: LASER-SHARP RESEARCH – March 2025

Laser-sharp Research / bladder cancer, cancer, Cancer therapy, immune activation, immune response, immunotherapy, laser-sharp research, Memorial Sloan Kettering Cancer Center, ML7710, padeliporfin

Coleman et al. / MSKCC developed a vascular-targeted therapy for bladder cancer. Padeliporfin is illuminated with the Modulight’s ML7710 laser, resulting in selective ablation of bladder tumors, without harming the healthy bladder tissue.

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Selectivity and anti-tumor immune elevation by vascular-targeted photodynamic therapy of mouse orthotopic bladder cancer model

Scientific papers / 753 nm, bladder cancer, cancer treatment, in vivo, Memorial Sloan Kettering Cancer Center, ML7710, PDT, vascular-targeted PDT, WST11

Published in: Photochemistry and Photobiology Authors: Jie Chen, Natalia Kudinova, Rebecca Dubrovsky, Jasmine Thomas, Karan Nagar, Lucas Nogueira, Avigdor Scherz, Kwanghee Kim, Jonathan Coleman

Selectivity and anti-tumor immune elevation by vascular-targeted photodynamic therapy of mouse orthotopic bladder cancer model Read More »

Carbonic anhydrase-9-targeted near-infrared photoimmunotherapy as a theranostic modality for clear cell renal cell carcinoma

Scientific papers / 690 nm, in vitro, in vivo, IR700, ML7710, NIH, Photoimmunotherapy, renal cancer

Published in: International Journal of Cancer Authors: Hiroshi Fukushima, Seiichiro Takao, Aki Furusawa, Motofumi Suzuki, Youfeng Yang, Christopher J. Ricketts, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Miyu Kano, Mark W. Ball, Peter L. Choyke, W. Marston Linehan, Hisataka Kobayashi

Carbonic anhydrase-9-targeted near-infrared photoimmunotherapy as a theranostic modality for clear cell renal cell carcinoma Read More »

Modulight Spotlights: LASER-SHARP RESEARCH – January 2025

Laser-sharp Research / cancer, immunology, immunotherapy, in vitro, in vivo, laser-sharp research, LaserSharpResearch, light activation, ML7710, research, targeted therapies

Kobayashi et al. at NIH developed a therapy which results in tumor cell membrane destruction and immunogenic cell death. When activated with the ML7710 laser, there was proven efficacy against various cancer cell types including pancreatic, oral, breast, and ovarian cancer.

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Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates

Scientific papers / 630 nm, clinical, light delivery, mesothelioma, ML7710, PDT, pleural PDT

Published in: Photochemistry and Photobiology Authors: Hongjing Sun, Michele M. Kim, Yi Hong Ong, Andreea Dimofte, Sunil Singhal, Theresa M. Busch, Keith A. Cengel, Timothy C. Zhu

Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates Read More »

Tissue factor targeted near‑infrared photoimmunotherapy: a versatile therapeutic approach for malignancies

Scientific papers / 690 nm, in vitro, in vivo, IR700, ML7710, NIH, Photoimmunotherapy

Published in: Cancer Immunology, Immunotherapy Authors: Seiichiro Takao, Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Shuhei Okuyama, Makoto Kano, Hiroshi Yamamoto, Motofumi Suzuki, Miyu Kano, Peter L. Choyke, Hisataka Kobayashi

Tissue factor targeted near‑infrared photoimmunotherapy: a versatile therapeutic approach for malignancies Read More »