ML7710

Modulight Spotlights: LASER-SHARP RESEARCH – June 2025

Chen-Hua Ma et al. ​​Optical Therapeutics & Nanotechnology Laboratory at University of Maryland combined photoimmunotherapy with ethanol ablation to achieve improved drug retention and light penetration, especially important for treating pigmented organs like liver and pancreas. Modulight’s ML7710 laser was used for both therapeutic activation of the nanoconstruct, as well as for theranostic monitoring of the process.

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Synergizing photodynamic therapy and ethanol ablation: Light-activatable sustained-exposure ethanol injection technology for enhanced tumor ablation

Published in: Bioengineering & Translational Medicine Authors: Chen-Hua Ma, Jeffrey Yang, John A. Quinlan, Kathryn McNaughton, Michele L. Kaluzienski, Tessa Hauser, Matthew F. Starost, Jenna L. Mueller, Huang-Chiao Huang  

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Impact of Vitamin C on Immune Response and Edema Following Near-Infrared Photoimmunotherapy (NIR-PIT)

Published in: Cancer Science Authors: Hiroshi Yamamoto, Aki Furusawa, Hiroshi Fukushima, Seiichiro Takao, Motofumi Suzuki, Makoto Kano, Miyu Kano, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi  

Impact of Vitamin C on Immune Response and Edema Following Near-Infrared Photoimmunotherapy (NIR-PIT) Read More »

Modulight Spotlights: LASER-SHARP RESEARCH – March 2025

Coleman et al. / MSKCC developed a vascular-targeted therapy for bladder cancer. Padeliporfin is illuminated with the Modulight’s ML7710 laser, resulting in selective ablation of bladder tumors, without harming the healthy bladder tissue.

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Selectivity and anti-tumor immune elevation by vascular-targeted photodynamic therapy of mouse orthotopic bladder cancer model

Published in: Photochemistry and Photobiology Authors: Jie Chen, Natalia Kudinova, Rebecca Dubrovsky, Jasmine Thomas, Karan Nagar, Lucas Nogueira, Avigdor Scherz, Kwanghee Kim, Jonathan Coleman  

Selectivity and anti-tumor immune elevation by vascular-targeted photodynamic therapy of mouse orthotopic bladder cancer model Read More »

Carbonic anhydrase-9-targeted near-infrared photoimmunotherapy as a theranostic modality for clear cell renal cell carcinoma

Published in: International Journal of Cancer Authors: Hiroshi Fukushima, Seiichiro Takao, Aki Furusawa, Motofumi Suzuki, Youfeng Yang, Christopher J. Ricketts, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Miyu Kano, Mark W. Ball, Peter L. Choyke, W. Marston Linehan, Hisataka Kobayashi  

Carbonic anhydrase-9-targeted near-infrared photoimmunotherapy as a theranostic modality for clear cell renal cell carcinoma Read More »

Modulight Spotlights: LASER-SHARP RESEARCH – January 2025

Kobayashi et al. at NIH developed a therapy which results in tumor cell membrane destruction and immunogenic cell death. When activated with the ML7710 laser, there was proven efficacy against various cancer cell types including pancreatic, oral, breast, and ovarian cancer.

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Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates

Published in: Photochemistry and Photobiology Authors: Hongjing Sun, Michele M. Kim, Yi Hong Ong, Andreea Dimofte, Sunil Singhal, Theresa M. Busch, Keith A. Cengel, Timothy C. Zhu  

Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates Read More »

Tissue factor targeted near‑infrared photoimmunotherapy: a versatile therapeutic approach for malignancies

Published in: Cancer Immunology, Immunotherapy Authors: Seiichiro Takao, Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Shuhei Okuyama, Makoto Kano, Hiroshi Yamamoto, Motofumi Suzuki, Miyu Kano, Peter L. Choyke, Hisataka Kobayashi  

Tissue factor targeted near‑infrared photoimmunotherapy: a versatile therapeutic approach for malignancies Read More »

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