Tag Archives: cancer

Light delivery optimization for H&N cancer treatment

Results Illumination with one fiber Some level of tissue heating was observed at all used light intensities. At lower intensities (60-100 mW/cm), less than 5% of the tumor was subjected to >60 ⁰C temperature, a point where irreversible thermal damage will immediately occur (photothermal ablation). At intensities of 150-200 mW/cm, 15-20% of the tumor was at >60 ⁰C temperature. At 400 mW/cm, which is FDA-recommended light irradiance for iPDT, a substantial portion of the tumor, up to 60%, was above 60 ⁰C.   Above figures Continue reading →Customer case Roswell Park Comprehensive Cancer Center was founded in 1898 as the first institute in the US devoted exclusively to cancer treatment and research. It is also the place where photodynamic therapy (PDT) was developed in the late 1970s by Thomas Dougherty. The PDT center at Roswell Park is a leader in the use of photodynamic therapy for treating different cancers. Research work includes treatment planning and light dosimetry for interstitial and intraoperative PDT to improve the quality of life and survival of cancer patients Continue reading →

Vision-sparing targeted phototherapy for uveal melanoma

Preliminary investigation of AU-011     Related Modulight products and Services   Related Publications Virus-Like Particle-Drug Conjugates Induce Protective, Long-lasting Adaptive Antitumor Immunity in the Absence of Specifically Targeted Tumor Antigens Rhonda C. Kines, Cynthia D. Thompson, Sean Spring, Zhenyu Li, Elisabet de los Pinos, Stephen Monks and John T. Schiller Cancer Immunology Research, 2021, 9 (6)   A Phase 1b/2 Open-label Clinical Trial to Evaluate the Safety and Efficacy of AU-011 for the Treatment of Choroidal Melanoma Prithvi Mruthyunjaya, Amy C. Schefler, Ivana K. Continue reading →Customer case Aura Biosciences, headquartered in Cambridge, MA, is developing a new class of photoactivated therapy for cancer patients together with National Cancer Institute, Emory Eye Center and Wills Eye Hospital. The therapy is based on virus-like conjugates and its primary indication is uveal melanoma. The goal is to eventually develop this technology for multiple cancer indications, such as non-muscle invasive bladder cancer (NMIBC), for which plans are underway to conduct a clinical trial. Dr. Carol Shields, MD – Aura Biosciences Dr. Rhonda Kines, PhD – Continue reading →

ML7710 for photoimmunotherapy against regulatory T cells in tumors

    Results Tumor growth was significantly suppressed by photoimmunotherapy, compared to control or IgG without light activation. Tumor growth suppression, as well as overall survival after photoimmunotherapy, were significantly better with F(ab´)2 fragments than with full IgG. This efficacy improvement might be related to killer T cells, which were detected in much higher numbers after photoimmunotherapy with F(ab´)2 fragments and are key cells for the generation of efficient systemic antitumor immunity.       Related Modulight products and Services   Related Publications The Effect Continue reading →Customer case The Laboratory of Molecular Theranostics is a major research section of the Molecular Imaging Program at National Cancer Institute (NCI) and is led by Dr. Hisataka Kobayashi. The groundbreaking research includes the development of imaging and theranostic probes, which can aid in cancer detection and treatment. Dr. Kobayashi has invented near-infrared photoimmunotherapy (NIR-PIT) with IRDye700DX, which is currently in FDA-designated fast-track Phase 3 trials for inoperable Head & Neck cancer. Dr. Hisataka Kobayashi M.D., PhD   Dr. Peter L. Choyke M.D., PhD   Continue reading →

ML7710 for fluorescence imaging: Detection of colorectal polyps in humans using c-Met targeted fluorescent peptide

Motivation for the study Polyps are small growths on the inner lining of the colon or rectum, affecting around 1 in 4 people over the age of 50. Certain types of polyps may eventually become cancerous, and colon cancer prevention relies on colonoscopy using white light to detect and remove the polyps. However, small and flat polyps are difficult to detect and frequently missed with this technique. More precise methods to detect polyps before they progress to colorectal cancer are urgently needed. GE Healthcare’s patented EMI-137 Continue reading →Customer Case Research by: GE Healthcare is a manufacturer and distributor of diagnostic imaging agents and radiopharmaceuticals, R&D collaborations with Leiden University MC for early detection of colorectal tumors. Modulight products: ML7710 series clinical laser system (635 nm, 3 W) Laser use: Clinical single-wavelength laser device used for exciting novel fluorescence probe used to detect colorectal polyps. Link to the study: Dr. James Hardwick, Professor of gastroenterology & hepatology Research topics: Professor Hardwick’s research has contributed to many key improvements in the detection and treatment of colorectal Continue reading →

Oncology

Modulight lasers in oncology Cancer touches almost all people worldwide - either personally or through someone you know. The treatment options for cancer are much better than a couple of decades ago but cancer still remains a leading cause of death killing 10 million people annually. Modulight participates in the fight against cancer by providing innovative clinical laser solutions for different laser-assisted therapies.  Since 2010, Modulight has offered complete medical laser systems for oncology professionals, and today these systems are equipped with state-of-the-art features like Continue reading →

Protected: Workshop on the best practices in clinical photodynamic therapy Password Protected

There is no excerpt because this is a protected post.Fri 24th April 6 pm, Gaylord Palms Resort, Kissimmee, FL Topics PDT dosimetry – Dr. Gal Shafirstein, Roswell Park Cancer Center, Buffalo, NY [embeddoc url="https://modulight.com/wp-content/uploads/2015/08/ASMLS-2015-PDT-Workshop-Prof.-Shafirstein-Final.pptx" width="280px" height="210px" download="all" viewer="microsoft"] Head & Neck – Dr. Merrill Biel, University of Minnesota Medical School, Minneapolis, MN Cholangiocarsinoma & Esophageal – Dr. Herbert C. Wolfsen, Mayo Clinic, Jacksonville, FL [embeddoc url="https://modulight.com/wp-content/uploads/2015/08/ASLMS_2015_Jones-Wolfsen.pptx" width="280px" height="210px" download="all" viewer="microsoft] Thoracic PDT – Dr. Patrick Ross Jr, The Ohio State University, Columbus, OH Mesothelioma – Dr. Keith Cengel, Perelman School of Medicine, Philadelphia, PA Breast – Dr. Continue reading →

Modulight launches the world’s first multi indication CE and ETL certified medical laser

Tampere, January 28, 2015 – Modulight, Inc., a leading biomedical laser manufacturer announced today ML7710 laser platform launch and certification. Unlike other lasers in the industry Modulight ML7710 has been certified and supports a wide range of indications and configurations. Medical CE and ETL marking are valid for all multi-channel (1–8 outputs) laser configurations between 400–2000nm and up to 15W vs. typical application and wavelength specific support. ML7710 supports directly several laser based treatment modalities, like photodynamic therapy (PDT), laser surgery, photo disinfection, and photo coagulation. This saves Continue reading →

Workshop on photodynamic therapy

Sat 7th Feb 5.30–9 pm Downtown San Francisco Topics • Discuss possible ways for enhancing the dissemination of PDT for cancer therapy – Prof. Gal Shafirstein, Roswell Park CI • Scope of active clinical studies in PDT – Prof. Keith Cengel, Univ. of Pennsylvania • Diagnosis, fluorescence and spectroscopy – Prof. Brian Pogue, Dartmouth College • Is dose planning enough or should we use online treatment monitoring? – Prof. Timothy Zhu, Univ. of Pennsylvania • Will multiple channel and/or multiple wavelength lasers make our life easier? – Dr. Timothy Baran, Continue reading →Sat 7th Feb 5.30–9 pm Downtown San Francisco Topics • Discuss possible ways for enhancing the dissemination of PDT for cancer therapy – Prof. Gal Shafirstein, Roswell Park CI • Scope of active clinical studies in PDT – Prof. Keith Cengel, Univ. of Pennsylvania • Diagnosis, fluorescence and spectroscopy – Prof. Brian Pogue, Dartmouth College • Is dose planning enough or should we use online treatment monitoring? – Prof. Timothy Zhu, Univ. of Pennsylvania • Will multiple channel and/or multiple wavelength lasers make our life easier? – Dr. Timothy Baran, Continue reading →

Workshop on the best practices in clinical photodynamic therapy

Fri 24th April 6 pm, Gaylord Palms Resort, Kissimmee, FL Workshop presentations Products and accessories on display • ML7710 – CE and ETL marked multi-purpose PDT laser platform • ML6700 – PDT-Illumination laser module tailored to PDT for R&D • ML6600 – Multi-wavelength laser module for PDT • External dose calibration module for PDT lasers NEW • Hand pieces for superficial PDT illumination NEW • Tailored PC software for PDT laser modules Speakers’ biographies   Click here to view our previous workshop at PW-2015. Related products: ML7710 – the tool for professionals »   |   Continue reading →Fri 24th April 6 pm, Gaylord Palms Resort, Kissimmee, FL Workshop presentations PDT dosimetry – Dr. Gal Shafirstein, Roswell Park Cancer Center, Buffalo, NY [embeddoc url=”https://modulight.com/wp-content/uploads/2015/08/ASMLS-2015-PDT-Workshop-Prof.-Shafirstein-Final.pptx” width=”280px” height=”210px” download=”all” viewer=”microsoft”] Head & Neck – Dr. Merrill Biel, University of Minnesota Medical School, Minneapolis, MN Cholangiocarsinoma & Esophageal – Dr. Herbert C. Wolfsen, Mayo Clinic, Jacksonville, FL [embeddoc url=”https://modulight.com/wp-content/uploads/2015/08/ASLMS_2015_Jones-Wolfsen.pptx” width=”280px” height=”210px” download=”all” viewer=”microsoft] Thoracic PDT – Dr. Patrick Ross Jr, The Ohio State University, Columbus, OH Mesothelioma – Dr. Keith Cengel, Perelman School of Medicine, Philadelphia, PA Breast – Continue reading →

Medical laser system ML7710 – Tool for professionals

Laser Platform for Clinical Use - ML7710Medical laser ML7710 delivers laser light precisely and safely. ML7710 supports all known photo­sensitizers, user-friendly self-calibration, and many other features for ease of use and ultimate patient safety & comfort. View ML7710 datasheet Overview of Clinical Laser ML7710 ML7710 is the most versatile multichannel & multi-indication medical laser in the world. The treatment flow of ML7710 has been optimized, and it can be further customized for specific needs. ML7710 supports all commercially available photosensitizers. As the only true medical Continue reading →