Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells

Published in: eBioMedicine Authors: Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S. Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L. Choyke, Martin J. Schnermann, Hisataka Kobayashi  Published in: eBioMedicine Authors: Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S. Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L. Choyke, Martin J. Schnermann, Hisataka Kobayashi A new method called phototruncation-assisted cell tracking (PACT) can be used to noninvasively track migration of immune cells to understand anti-cancer immunity mechanisms. PACT is based on irreversible photo-induced truncation reaction, transforming Cy7 into Cy5 when exposed to NIR light (780 nm). PACT was used in this study to monitor spatiotemporal migration of immune cells between tumor and Continue reading →

Carrier-Free, Amorphous Verteporfin Nanodrug for Enhanced Photodynamic Cancer Therapy and Brain Drug Delivery

Published in: Advanced Science Authors: John A. Quinlan, Collin T. Inglut, Payal Srivastava, Idrisa Rahman, Jillian Stabile, Brandon Gaitan, Carla Arnau Del Valle, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Baktiar Karim, Nina Connolly, Robert W. Robey, Graeme F. Woodworth, Michael M. Gottesman, Huang-Chiao Huang University of Maryland  Published in: Advanced Science Authors: John A. Quinlan, Collin T. Inglut, Payal Srivastava, Idrisa Rahman, Jillian Stabile, Brandon Gaitan, Carla Arnau Del Valle, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Baktiar Karim, Nina Connolly, Robert W. Robey, Graeme F. Woodworth, Michael M. Gottesman, Huang-Chiao Huang University of Maryland Glioblastoma (GBM) is hard to treat due to cellular invasion into functioning brain tissues, limited drug delivery, and evolved treatment resistance. Recurrence is nearly universal even after surgery, chemotherapy, and radiation. Photodynamic therapy (PDT) involves photosensitizer administration followed by light activation to generate reactive oxygen species at tumor sites, thereby killing cells or Continue reading →

Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids

Published in: Cell & Bioscience Authors: Aaron Sorrin, Anika Dasgupta, Kathryn McNaughton, Carla Arnau Del Valle, Keri Zhou, Cindy Liu, Dana M. Roque & Huang Chiao Huang Within the last decade, poly(ADP-ribose) polymerase inhibitors (PARPi) have emerged in the clinic as an effective treatment for numerous malignancies. Preclinical data have demonstrated powerful combination effects of PARPi paired with photodynamic therapy (PDT), which involves light-activation of specialized dyes (photosensitizers) to stimulate cancer cell death through reactive oxygen species generation. In this study, a novel combination strategy was Continue reading →

Multiwavelength narrow linewidth laser system for Ba+ quantum computing applications

Published in: QUANTUM WEST SPIE 2024 Authors: Kostiantyn Nechay, Luukas Kuusela, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa  Published in: QUANTUM WEST SPIE 2024 Authors: Kostiantyn Nechay, Luukas Kuusela, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa Quantum information processing (QIP) approach based on trapped ions is a promising technology that exploits different ion species as individual qubits and qubit gates, while featuring long coherence times, high fidelity of operations, fast readout, and ion-ion gate entanglement. The practical usefulness of trapped-ion quantum computer depends on its further scaling to a large number of qubits. Meanwhile, trapped-ion quantum computer relies on a set of single-frequency lasers, utilizing Continue reading →

Narrow linewidth 650 nm DBR laser diode for quantum applications

Published in: QUANTUM WEST SPIE 2024 Authors: Riina Ulkuniemi, Luukas Kuusela, Mika Mähönen, Timo Aho, Jussi Hämelahti, Andreas Schramm, Soile Talmila, Pekko Sipilä, Petteri Uusimaa  Published in: QUANTUM WEST SPIE 2024 Authors: Riina Ulkuniemi, Luukas Kuusela, Mika Mähönen, Timo Aho, Jussi Hämelahti, Andreas Schramm, Soile Talmila, Pekko Sipilä, Petteri Uusimaa Laser systems are utilized in quantum for various applications. Multiple wavelengths and tailored solutions are required depending on the technology that the laser will be applied to. For instance, lasers can be used for controlling particles and molecules, including excitations of the quantum systems. Key performance requirements for lasers used in these applications include narrow linewidth, frequency stability, and single-frequency Continue reading →

Narrow linewidth VECSELs for Ba+ cooling at 493 nm

Published in: LASE SPIE 2024 Authors: Kostiantyn Nechay, Andreas Schramm, Mika Mähönen, Soile Talmila, Jussi Hämelahti, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa  Published in: LASE SPIE 2024 Authors: Kostiantyn Nechay, Andreas Schramm, Mika Mähönen, Soile Talmila, Jussi Hämelahti, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa Quantum information processing based on trapped ion technology is one of the leading platforms, heavily relying on a set of single-frequency lasers in its core operations. Narrow linewidth lasers perform atom photoionization, cooling, state-preparation and read-out. In this work we demonstrate in-house designed and fabricated optically pumped semiconductor laser gain mirror comprised of InGaAs quantum wells and GaAs/AlAs distributed Bragg reflector. We demonstrate Continue reading →

Narrow linewidth 935 nm DBR laser diode for quantum applications

Published in: OPTO SPIE 2024 Authors: Mika Mähönen, Riina Ulkuniemi, Luukas Kuusela, Timo Aho, Andreas Schramm, Soile Talmila, Pekko Sipilä, Petteri Uusimaa  Published in: OPTO SPIE 2024 Authors: Mika Mähönen, Riina Ulkuniemi, Luukas Kuusela, Timo Aho, Andreas Schramm, Soile Talmila, Pekko Sipilä, Petteri Uusimaa Laser systems with ultra-stable and narrow linewidth operation are a crucial part for many quantum computing and quantum sensing technologies, such as trapped ion and neutral ion approaches. The particular interest in this work is the fabrication of a 935 nm Distributed Bragg reflector (DBR) laser which can be used to repump Yb ions permitting Doppler cooling. DBR’s can provide output powers in Continue reading →

Narrow linewidth DBR and MOPA laser systems for quantum applications in the 7xx nm regime

Published in: OPTO SPIE 2024 Authors: Luukas Kuusela, Timo Aho, Riina Ulkuniemi, Mika Mähönen, Jussi Hämelahti, Andreas Schramm, Soile Talmila, Pekko Sipilä, Petteri Uusimaa  Published in: OPTO SPIE 2024 Authors: Luukas Kuusela, Timo Aho, Riina Ulkuniemi, Mika Mähönen, Jussi Hämelahti, Andreas Schramm, Soile Talmila, Pekko Sipilä, Petteri Uusimaa Lasers are a key enabling technology in the field of quantum computing, quantum sensing and quantum metrology. These applications require technically challenging properties from the lasers in use, such as stable and precisely controlled wavelength, up to watt level output power, and a narrow linewidth. Semiconductor diode lasers offer a very compact size, low power consumption, as well as scalability of Continue reading →

High brightness long lifetime 650nm single-mode laser diodes and arrays for display, printing, and quantum applications

Published in: LASE SPIE 2024 Authors: Riina Ulkuniemi, Andreas Schramm, Ville Vilokkinen, Jari Nikkinen, Petteri Uusimaa  Published in: LASE SPIE 2024 Authors: Riina Ulkuniemi, Andreas Schramm, Ville Vilokkinen, Jari Nikkinen, Petteri Uusimaa Individually addressable laser diode arrays (IAB) have been first demonstrated in near-infrared wavelengths, 8xx nm and 9xx nm, being mostly utilized in the digital printing industry. When moving towards visible wavelengths, other applications emerge. Examples of these are various display applications, including AR/VR products and head-up-displays. In addition, novel applications for narrow linewidth lasers have emerged in the field of quantum computing. In this paper, we present our latest Continue reading →

Tailorable semiconductor laser platform in the 7xx nm regime

Published in: OPTO SPIE 2024 Authors: Andreas Schramm, Luukas Kuusela, Mika Mähönen, Soile Talmila, Ville Vilokkinen, Petteri Uusimaa  Published in: OPTO SPIE 2024 Authors: Andreas Schramm, Luukas Kuusela, Mika Mähönen, Soile Talmila, Ville Vilokkinen, Petteri Uusimaa We report on tailoring capabilities in the 7xx nm wavelength range utilizing GaAsP or InGaAsP quantum wells (QW) embedded in AlGaAs. Laser structures are grown using metal-organic chemical vapor deposition. Wafers and manufactured lasers are thoroughly characterized, and lifetime tests are performed to validate laser reliabilities. Changing QW parameters enables us to tune the wavelength or polarization of the laser emission.   Read the article here