Tag: Photodynamic therapy

Modulight Spotlights: LASER-SHARP RESEARCH – December 2025

Laser-sharp Research / imaging, in vitro, in vivo, laser-sharp research, ML6600, multi-wavelength, oxygen, Photodynamic therapy, treatment guidance, treatment monitoring, tumor, ultrasound / December 30, 2025

Deeksha Sankepalle and the group at Tufts University, USA developed an advanced multi-wavelength photoacoustic imaging system. It integrates a pulsed, tunable laser with an ultrasound acquisition platform to provide functional 3D imaging. The system enables real-time, non-invasive, high-resolution imaging of tumor vasculature by tracking oxygen saturation in the tumor.

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Heterogeneous tumor blood oxygenation dynamics during phototherapy deciphered with real-time label-free photoacoustic imaging

Scientific papers / 690 nm, in vivo, ML6600, nature, NIH, PDT, Photodynamic therapy / June 4, 2025

Published in: npj Acoustics Authors: Andrew Langley, Allison Sweeney, Ronak T. Shethia, Brooke Bednarke, Faizah Wulandana, Marvin Xavierselvan, Srivalleesha Mallidi

Heterogeneous tumor blood oxygenation dynamics during phototherapy deciphered with real-time label-free photoacoustic imaging Read More »

Modulight Spotlights: LASER-SHARP RESEARCH – April 2025

Laser-sharp Research / drug delivery, imaging, in vitro, laser-sharp research, light activation, ML6600, nanoparticles, Photodynamic therapy, Photoimmunotherapy, verteporfin / April 30, 2025

Gokalp et al. from University of Massachusetts and Tufts University constructed an innovative liquid metal nanoparticle platform, which has tumor cell targeting and enhanced encapsulation of verteporfin. Charactierization in vitro with the help of ML6600 laser showed effective in vitro phototoxicity.

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Liquid metal nanoparticles for enhanced delivery of benzoporphyrin derivative in photodynamic cancer therapy

Scientific papers / 690 nm, Cancer therapy, imaging, in vitro, ML6600, nanoparticles, PDT, Photodynamic therapy, photosensitizer, phototoxicity, tumor / April 15, 2025

Published in: Photochemistry and Photobiology Authors: Sumeyra Gokalp, Marvin Xavierselvan, Mohammad Forhad Khan, Ronak Shethia, Sima Khani, Ryan H. Riddell, Anna V. Krasnoslobodtseva, Srivalleesha Mallidi, Michelle Foster

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A Comprehensive Study of Reactive Oxygen Species Explicit Dosimetry for Pleural Photodynamic Therapy

Scientific papers / 630 nm, clinical, dosimetry, mesothelioma, ML7710, oxygen, PDT, Photodynamic therapy, photofrin, photosensitizer, pleural PDT, ROS detection, tumor / November 22, 2024

Published in: Antioxidants Authors: Hongjing Sun, Yihong Ong, Michele M. Kim, Andreea Dimofte, Sunil Singhal, Keith A. Cengel, Arjun G. Yodh, Timothy C. Zhu

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Modulight Spotlights: LASER-SHARP RESEARCH – November 2024

Laser-sharp Research / 5-ALA, colorectal cancer, illumination, in vivo, laser-sharp research, light activation, Lung cancer, ML6600, noveltherapies, perfusion, Photodynamic therapy / November 19, 2024

Only 1 in 10 patients qualify for surgical resection of the pulmonary metastases – thus the management remains a significant clinical challenge. K. Ramadan et al. studied PDT and demonstrated the feasibility and safety of the procedure using 5-ALA and Chlorin e6 drugs with Modulight’s ML6600 laser.

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Development of a protocol for whole-lung in vivo lung perfusion-assisted photodynamic therapy using a porcine model

Scientific papers / 5-ALA, 665 nm, in vivo, Lung cancer, ML6600, PDT, Photodynamic therapy / November 15, 2024

Published in: Journal of Biomedical Optics Authors: Khaled Ramadan, Tina Saeidi, Edson Brambate, Vanderlei Bagnato, Marcelo Cypel, Lothar Lilge

Development of a protocol for whole-lung in vivo lung perfusion-assisted photodynamic therapy using a porcine model Read More »

Age-related Macular Degeneration (AMD)

Application Note / age-related macular degeneration, AMD, application note, ML6710i, ophthalmic treatments, ophthalmology, PDT, Photodynamic therapy / June 27, 2024

Age-related Macular Degeneration (AMD) Age-related Macular Degeneration (AMD) is a disease causing choroidal neovascularization (CNV) and consequent irreversible damage in the macula. AMD is classified into dry (atrophic) and wet (exudative) forms, with the latter causing faster vision loss and being the leading cause of blindness in people over 65. Introduction to AMD Age-related Macular

Photodynamic Therapy for Cancer Treatment – Review Article by Nature

Press Releases / collaboration, imaging, PDT, Photodynamic therapy, priming, review article / June 20, 2024

Modulight announces a significant contribution to the field of cancer treatment through the publication of a comprehensive review on Photodynamic Therapy (PDT) in Nature Reviews Bioengineering: “Engineering Photodynamics for Treatment, Priming, and Imaging”.

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