Author Archives: Modulight

WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice

January 1, 2018 by Modulight
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Published in: Theranostics Authors: Volker Neuschmelting, Kwanghee Kim, Jaber Malekzadeh-Najafabadi, Sylvia Jebiwott, Jaya Prakash, Avigdor Scherz, Jonathan A. Coleman, Moritz F. Kircher, Vasilis Ntziachristos    Published in: Theranostics Authors: Volker Neuschmelting, Kwanghee Kim, Jaber Malekzadeh-Najafabadi, Sylvia Jebiwott, Jaya Prakash, Avigdor Scherz, Jonathan A. Coleman, Moritz F. Kircher, Vasilis Ntziachristos   The research group studied vascular-targeted photodynamic therapy (VTP). They used laser to activate Tookad (WST11) photosensitizer in VTP using renal cancer mouse model to develop multispectral optoacoustic tomography (MSOT) monitoring method for VTP.   Read the article here

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation

November 28, 2016 by Modulight
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Published in: Cardiovascular therapeutics Authors: Manish Jain, Matthieu Zellweger, Georges Wagnières, Hubert van den Bergh, Stéphane Cook, Marie-Noelle Giraud  Published in: Cardiovascular therapeutics Authors: Manish Jain, Matthieu Zellweger, Georges Wagnières, Hubert van den Bergh, Stéphane Cook, Marie-Noelle Giraud   Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction of a coronary artery. During the last decade, scientific evidence demonstrated Continue reading →

Fast quantitative ROS detection based on dual-color single rare-earth nanoparticle imaging reveals signaling pathway kinetics in living cells

November 28, 2016 by Modulight
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Published in: Nanoscale Authors: M. Abdesselem, R. Ramodiharilafy, L. Devys, T. Gacoin, A. Alexandrou, C. I. Bouzigues    Published in: Nanoscale Authors: M. Abdesselem, R. Ramodiharilafy, L. Devys, T. Gacoin, A. Alexandrou, C. I. Bouzigues   Reactive oxygen species (ROS), and notably hydrogen peroxide H2O2, are cellular second messengers that are known to control a variety of signaling processes.  Modulight ML6600 series laser was used to excite colloidal nanoparticles for luminescence measurements as part of a rapid ROS detection probe. The probe was used to study signaling pathway kinetics in living cells.   Read the article here

Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial

July 27, 2016 by Modulight
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Published in: Lancet Oncology Authors: Ahmed A Sultan, Waseem Jerjes, Kristian Berg, Anders Høgset, Charles A Mosse, Rifat Hamoudi, Zaid Hamdoon, Celia Simeon, Dawn Carnell, Martin Forster, Colin Hopper    Published in: Lancet Oncology Authors: Ahmed A Sultan, Waseem Jerjes, Kristian Berg, Anders Høgset, Charles A Mosse, Rifat Hamoudi, Zaid Hamdoon, Celia Simeon, Dawn Carnell, Martin Forster, Colin Hopper   Photochemical internalization with bleomycin was studied in a Phase 1, first-in-man trial for local recurrent, advanced, or metastatic H&N cancer. Modulight laser was used for activation of TPCS2a photosensitizer at the surface of the target tumor. 12 patients completed the 3-month follow-up, with maximum tolerated dose of TPCS2a being established to 1.0 mg/kg.   Read Continue reading →

EGFR targeted nanobody–photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer

May 10, 2016 by Modulight
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Published in: Journal of Controlled Release Authors: Pieter B.A.A. van Driel, Martin C. Boonstra, Maxime D. Slooter, Raimond Heukers, Marieke A. Stammes, Thomas J.A. Snoeks, Henriette S. de Bruijn, Paul J. van Diest, Alexander L. Vahrmeijer, Paul M.P. van Bergen en Henegouwen, Cornelis J.H. van de Velde, Clemens W.G.M. Löwik, Dominic J. Robinson, Sabrina Oliveira    Published in: Journal of Controlled Release Authors: Pieter B.A.A. van Driel, Martin C. Boonstra, Maxime D. Slooter, Raimond Heukers, Marieke A. Stammes, Thomas J.A. Snoeks, Henriette S. de Bruijn, Paul J. van Diest, Alexander L. Vahrmeijer, Paul M.P. van Bergen en Henegouwen, Cornelis J.H. van de Velde, Clemens W.G.M. Löwik, Dominic J. Robinson, Sabrina Oliveira   Photodynamic therapy (PDT) induces cell death through local light activation of a photosensitizer (PS) and has been used to treat head and neck cancers. Yet, common PS lack tumor Continue reading →

Photodynamic Therapy of Non–Small Cell Lung Cancer. Narrative Review and Future Directions

February 1, 2016 by Modulight
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Published in: Annals of the American Thoracic Society Authors: Gal Shafirstein 1,2, Athar Battoo 3, Kassem Harris 4, Heinz Baumann 5, Sandra O. Gollnick 1,6, Joerg Lindenmann 1,7, and Chukwumere E. Nwogu 3 1Photodynamic Therapy Center 2Department of Cell Stress Biology 3Department of Thoracic Surgery 4Department of Medicine, Interventional Pulmonology 5Department of Molecular and Cellular Biology, and 6Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York; and 7Division of Thoracic and Hyperbaric Surgery, Medical University Graz, Graz, Austria Corresponding Author: Gal Shafirstein    Published in: Annals of the American Thoracic Society Authors: Gal Shafirstein 1,2, Athar Battoo 3, Kassem Harris 4, Heinz Baumann 5, Sandra O. Gollnick 1,6, Joerg Lindenmann 1,7, and Chukwumere E. Nwogu 3 1Photodynamic Therapy Center 2Department of Cell Stress Biology 3Department of Thoracic Surgery 4Department of Medicine, Interventional Pulmonology 5Department of Molecular and Cellular Biology, and 6Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York; and 7Division of Thoracic and Hyperbaric Surgery, Medical University Graz, Graz, Austria Corresponding Author: Gal Shafirstein     The paper describes the history of lung cancer PDT and results from relevant studies. Continue reading →

Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met

July 13, 2015 by Modulight
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Published in: Nature Medicine Authors: Jacobus Burggraaf, Ingrid M C Kamerling, Paul B Gordon, Lenneke Schrier, Marieke L de Kam, Andrea J Kales, Ragnar Bendiksen, Bård Indrevoll, Roger M Bjerke, Siver A Moestue, Siavash Yazdanfar, Alexandra M J Langers, Marit Swaerd-Nordmo, Geir Torheim, Madhuri V Warren, Hans Morreau, Philip W Voorneveld, Tessa Buckle, Fijs W B van Leeuwen, Liv-Ingrid Ødegårdstuen, Grethe T Dalsgaard, Andrew Healey, James C H Hardwick    Published in: Nature Medicine Authors: Jacobus Burggraaf, Ingrid M C Kamerling, Paul B Gordon, Lenneke Schrier, Marieke L de Kam, Andrea J Kales, Ragnar Bendiksen, Bård Indrevoll, Roger M Bjerke, Siver A Moestue, Siavash Yazdanfar, Alexandra M J Langers, Marit Swaerd-Nordmo, Geir Torheim, Madhuri V Warren, Hans Morreau, Philip W Voorneveld, Tessa Buckle, Fijs W B van Leeuwen, Liv-Ingrid Ødegårdstuen, Grethe T Dalsgaard, Andrew Healey, James C H Hardwick   Laser was used in collaboration with GE Healthcare as a light source for NIR fluorescence Continue reading →