Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging

Published in: Theranostics

Authors: Henriette S. de Bruijn, Vida Mashayekhi, Tom J.L. Schreurs, Pieter B.A.A. van Driel, Gustav J. Strijkers, Paul J. van Diest, Clemens W.G.M. Lowik, Ann L.B. Seynhaeve, Timo L.M. ten Hagen, Jeanine J. Prompers, Paul M.P. van Bergen en Henegouwen, Dominic J. Robinson, Sabrina Oliveira


Laser was used to study the effectiveness of two EGFR-targeted nanobody-photosensitizer (IRDye700DX) conjugates for PDT both in vivo and in vitro. The biodistribution (by fluorescence imaging), cellular responses and vascular effects of the two prepared conjugates were promising. Results also show that vascular effects play a role in therapy response.


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