Tag: in vitro

Modulight Spotlights: LASER-SHARP RESEARCH – September 2026

Laser-sharp Research / bioluminescence, in vitro, laser-sharp research, luciferase, ML6600, ovarian cancer, PDT, Photodynamic Priming, Photodynamic therapy / September 29, 2026

Could locally generated bioluminescence activate photoimmunotherapy for disseminated metastatic disease? Researchers at Northeastern University and Cornell University engineered immune cells to produce blue or red light and activate verteporfin in 3D ovarian cancer spheroid models. While bioluminescence remained below the threshold for effective cytotoxicity, conventional light activation with the ML6500 laser system produced a clear light dose-dependent therapeutic response.

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Modulight Spotlights: LASER-SHARP RESEARCH – August 2026

Laser-sharp Research / 690 nm, antibiotic resistance, antibiotics, antimicrobial, antimicrobial resistance, in vitro, laser-sharp research, LaserSharpResearch, light activation, ML6600, MRSA, nanotechnology, photodynamics, targeted therapies, targetedtherapies / August 25, 2026

Modulight Spotlights: LASER-SHARP RESEARCH – August 2026 A fresh publication from Tayyaba Hasan lab at Massachusetts General Hospital and Harvard Medical School has introduced a new solution for antibiotic-resistant bacterial strains. The team developed photoactivatable nanocarriers to enable co-delivery of antibiotic minocycline together with a light-sensitive compound into bacterial cells. When activated with a low

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Near-infrared Photoimmunotherapy Targeting Canine Mammary Tumors: Comparative Oncology for Overcoming Human Breast Cancer

Scientific papers / 690 nm, breast cancer, in vitro, in vivo, ML7710, NIH, Photoimmunotherapy, tumor / July 29, 2026

Published in: Anticancer Research Authors: Motofumi Suzuki, Aki Furusawa, Hiroshi Yamamoto, Ko Kitamura, Makoto Kano, Miyu Kano, Seiichiro Takao, Yukinari Kato, Amy K. Leblanc, Peter L. Choyke, Hisataka Kobayashi

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Mirabody–IR700: A novel EGFR-targeting platform for photoimmunotherapy

Scientific papers / 690 nm, cancer, cytotoxicity, in vitro, in vivo, IR700, ML7710, Photoimmunotherapy, research, tumor / July 29, 2026

Published in: Biomedicine & Pharmacotherapy Authors: Citra R.A.P. Palangka, Motofumi Suzuki, Ayaka Kanai, Azusa Nitta, Junichi Takagi, Hirofumi Hanaoka

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Photoactivable nanoliposomal delivery of minocycline to combat antimicrobial resistance

Scientific papers / 690 nm, antibiotics, antimicrobial, antimicrobial therapy, antimicrobialtherapy, benzoporphyrin derivative, BPD, in vitro, liposomes, ML6600, nanotechnology, PDT, photodynamics, targeted therapy / July 16, 2026

Published in: Journal of Drug Delivery Science and Technology Authors: Jose Quílez−Alburquerque, Fernanda Viana Cabral, Yanfang Feng, Tayyaba Hasan

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Photothermal and photo-oxidation mediated release of lipophilic paclitaxel from liposomes: from formulation to in vitro efficacy and molecular dynamics simulations

Scientific papers / 689 nm, 690 nm, 808 nm, drug delivery, ICG, in vitro, liposomes, ML6600, ML8500, MLAKIT, nanomaterials, nanomedicine, Paclitaxel, photo-oxidation, photothermal therapy, University of Helsinki, verteporfin / July 14, 2026

Published in: International Journal of Pharmaceutics Authors: Eija Ilvesroiha, Suvi Heinonen, Riikka Rimmistö, Timo Oksanen, Nikita Durandin, Alex Bunker, Artturi Koivuniemi, Tatu Lajunen, Timo Laaksonen

Photothermal and photo-oxidation mediated release of lipophilic paclitaxel from liposomes: from formulation to in vitro efficacy and molecular dynamics simulations Read More »

Modulight Spotlights: LASER-SHARP RESEARCH – June 2026

Laser-sharp Research / antibiotic resistance, antimicrobial, antimicrobial therapy, appendicitis, disinfection, in vitro, in vivo, intra-abdominal infection, laparoscopic surgery, laser therapy, laser-sharp research, methylene blue, ML7710, PDT, pediatric surgery, perforation, Photodynamic therapy, Photoimmunotherapy, photomedicine, translational research / June 22, 2026

Research teams led by Dr. Timothy Baran and Dr. Nicole Wilson investigated laser-activated methylene blue therapy for perforated appendicitis. Using the ML7710 laser system, the study demonstrated a feasible and safe resistance-independent antimicrobial treatment approach.

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Modulight Spotlights: LASER-SHARP RESEARCH – March 2026

Laser-sharp Research / chemo resistance, in vitro, in vivo, laser-sharp research, ML7710, ML8500, National Cancer Institute, ovarian cancer, peritoneal carcinoma, photoimmunoconjugates, Photoimmunotherapy, targeted therapies, University of Maryland / March 12, 2026

Modulight Spotlights: LASER-SHARP RESEARCH – March 2026 The development of chemoresistance presents a major challenge in treating peritoneal metastasis, which often occurs in advanced ovarian cancer. To tackle this, Kaitlyn Moore and teams at University of Maryland and National Cancer Institute evaluated photoimmunotherapy as a solution to inhibit a drug efflux pump on cancer cells

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Modulight Spotlights: LASER-SHARP RESEARCH – January 2026

Laser-sharp Research / apoptosis, BPD, cancer, ferroptosis, in vitro, in vivo, laser-sharp research, light activation, ML6600, ovarian cancer, Photoimmunotherapy, photosensitizer / January 28, 2026

Modulight Spotlights: LASER-SHARP RESEARCH – January 2026 The highlight of the month goes to teams of researchers led by Prof. Imran Rizvi at University of North Carolina at Chapel Hill. Their latest publication shows that certain light-activated therapy with BPD photosensitizer and ML6600 laser can induce ferroptosis-like cell death, including formation of lipid peroxides, in

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