Tag: in vitro

Modulight Spotlights: LASER-SHARP RESEARCH – June 2025

Laser-sharp Research / Cancer therapy, fluorescence, in vitro, in vivo, laser-sharp research, liver cancer, ML7710, pancreas, pancreatic cancer, theranostics, University of Maryland

Chen-Hua Ma et al. Optical Therapeutics & Nanotechnology Laboratory at University of Maryland combined photoimmunotherapy with ethanol ablation to achieve improved drug retention and light penetration, especially important for treating pigmented organs like liver and pancreas. Modulight’s ML7710 laser was used for both therapeutic activation of the nanoconstruct, as well as for theranostic monitoring of the process.

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Synergizing photodynamic therapy and ethanol ablation: Light-activatable sustained-exposure ethanol injection technology for enhanced tumor ablation

Scientific papers / Cancer therapy, fluorescence, in vitro, in vivo, liver cancer, ML7710, pancreas, pancreatic cancer, theranostics, University of Maryland

Published in: Bioengineering & Translational Medicine Authors: Chen-Hua Ma, Jeffrey Yang, John A. Quinlan, Kathryn McNaughton, Michele L. Kaluzienski, Tessa Hauser, Matthew F. Starost, Jenna L. Mueller, Huang-Chiao Huang

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Modulight Spotlights: LASER-SHARP RESEARCH – May 2025

Laser-sharp Research / anti-infection, antibiotic resistance, antimicrobial, bacterial infection, hydrogels, in vitro, infections, laser-sharp research, ML6600, photothermal therapy, wound healing

Cheng-Yu Lai et al. at Florida International University explores a solution for antibiotic-free wound healing. A photothermally controllable hydrogel was illuminated by NIR light from ML6600 laser, causing complete eradication of bacteria.

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Modulight Spotlights: LASER-SHARP RESEARCH – April 2025

Laser-sharp Research / drug delivery, imaging, in vitro, laser-sharp research, light activation, ML6600, nanoparticles, Photodynamic therapy, Photoimmunotherapy, verteporfin

Gokalp et al. from University of Massachusetts and Tufts University constructed an innovative liquid metal nanoparticle platform, which has tumor cell targeting and enhanced encapsulation of verteporfin. Charactierization in vitro with the help of ML6600 laser showed effective in vitro phototoxicity.

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Impact of Vitamin C on Immune Response and Edema Following Near-Infrared Photoimmunotherapy (NIR-PIT)

Scientific papers / 690 nm, in vitro, in vivo, IR700, IRDye700DX, ML7710, NIR, PDT, Photoimmunotherapy, tumor

Published in: Cancer Science Authors: Hiroshi Yamamoto, Aki Furusawa, Hiroshi Fukushima, Seiichiro Takao, Motofumi Suzuki, Makoto Kano, Miyu Kano, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi

Impact of Vitamin C on Immune Response and Edema Following Near-Infrared Photoimmunotherapy (NIR-PIT) Read More »

Liquid metal nanoparticles for enhanced delivery of benzoporphyrin derivative in photodynamic cancer therapy

Scientific papers / 690 nm, Cancer therapy, imaging, in vitro, ML6600, PDT, Photodynamic therapy, photosensitizer, tumor

Published in: Photochemistry and Photobiology Authors: Sumeyra Gokalp, Marvin Xavierselvan, Mohammad Forhad Khan, Ronak Shethia, Sima Khani, Ryan H. Riddell, Anna V. Krasnoslobodtseva, Srivalleesha Mallidi, Michelle Foster

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Harnessing liposomal nanocellulose hydrogel for NIR-light driven on-demand drug delivery

Scientific papers / 808 nm, drug delivery, drug distribution, hydrogels, in vitro, liposomes, ML8500, nanoparticles, PDT, University of Helsinki

Published in: Carbohydrate Polymer Technologies and Applications Authors: Puja Gangurde, Zahra Gounani, Jacopo Zini, Roberta Teixeira Polez, Monika Osterberg, Patrick Lauren, Tatu Lajunen, Timo Laaksonen

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Modulight Spotlights: LASER-SHARP RESEARCH – February 2025

Laser-sharp Research / breast cancer, cancer, Cancer therapy, cancer treatment, immunology, immunotherapy, in vitro, in vivo, laser-sharp research, ML6600, photosensitizer, research, tumor, verteporfin

A. Lepland and the teams at University of Tartu, Estonia and Veneto Institute of Oncology, Italy, developed a new immunotherapy for triple negative breast cancer, using Modulight ML6000-series laser. Tumor growth slowed down and the cancer’s spreading to the lungs was suppressed.

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Carbonic anhydrase-9-targeted near-infrared photoimmunotherapy as a theranostic modality for clear cell renal cell carcinoma

Scientific papers / 690 nm, in vitro, in vivo, IR700, ML7710, NIH, Photoimmunotherapy, renal cancer

Published in: International Journal of Cancer Authors: Hiroshi Fukushima, Seiichiro Takao, Aki Furusawa, Motofumi Suzuki, Youfeng Yang, Christopher J. Ricketts, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Miyu Kano, Mark W. Ball, Peter L. Choyke, W. Marston Linehan, Hisataka Kobayashi

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