Tag: targeted therapies

Modulight Spotlights: LASER-SHARP RESEARCH – March 2026

Laser-sharp Research / chemo resistance, in vitro, in vivo, laser-sharp research, ML7710, ML8500, National Cancer Institute, ovarian cancer, peritoneal carcinoma, photoimmunoconjugates, Photoimmunotherapy, targeted therapies, University of Maryland / March 12, 2026

Modulight Spotlights: LASER-SHARP RESEARCH – March 2026 The development of chemoresistance presents a major challenge in treating peritoneal metastasis, which often occurs in advanced ovarian cancer. To tackle this, Kaitlyn Moore and teams at University of Maryland and National Cancer Institute evaluated photoimmunotherapy as a solution to inhibit a drug efflux pump on cancer cells [...]

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Modulight Spotlights: LASER-SHARP RESEARCH – January 2025

Laser-sharp Research / cancer, immunology, immunotherapy, in vitro, in vivo, laser-sharp research, LaserSharpResearch, light activation, ML7710, research, targeted therapies / January 22, 2025

Kobayashi et al. at NIH developed a therapy which results in tumor cell membrane destruction and immunogenic cell death. When activated with the ML7710 laser, there was proven efficacy against various cancer cell types including pancreatic, oral, breast, and ovarian cancer.

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Modulight Spotlights: LASER-SHARP RESEARCH – August 2024

Laser-sharp Research / application fiber, diffuser fiber, dyes, endoscopy, esophageal cancer, gastrointestinal, gastroscopy, IRDye700DX, Kill cancer, lateral emitting laser fiber, ML7710, Photoimmunotherapy, PIT, precision, targeted therapies / August 7, 2024

Hirofumi Hanaoka and the team at Kansai Medical University, Japan developed a new laser fiber and method for illumination of narrow cavities, such as esophagus. The new fiber together with ML7710 laser allowed better illumination of the entire tumor compared to existing fibers, resulting in tumor growth suppression.

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Fluorescence-guided, targeted photochemotherapy of peritoneal carcinomatosis

Scientific papers / BIOS, carcinomatosis, fluorescence-guided surgery, ML6600, ML7710, Modulight authors, PDT, peritoneal cavity, SPIE BIOS 2023, targeted therapies, UMD / March 17, 2023

Presented in: SPIE BIOS 2023 Authors: Barry J. Liang, Robert Perttilä, Sumiao Pang, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron J. Sorrin, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang

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Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW

Scientific papers / 690 nm, BPD, cetuximab, fluorescence imaging, H&N cancer, in vivo, IRDye800CW, ML6500, Photoimmunotherapy, PIT, targeted therapies, tumor / June 28, 2022

Published in: Frontiers in Oncology Authors: Chanda Bhandari, John Fakhry, Menitte Eroy, Jane Junghwa Song, Kimberley Samkoe, Tayyaba Hasan, Kenneth Hoyt, Girgis Obaid

Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW Read More »

Modulight Spotlights: LASER-SHARP RESEARCH – August 2021

Laser-sharp Research / laser-sharp research, lasers in science, Modulight in science, oral carcinoma, targeted therapies / September 1, 2021

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Nanobody-targeted photodynamic therapy for the treatment of feline oral carcinoma: a step towards translation to the veterinary clinic

Scientific papers / 690 nm, flow cytometry, in vitro, ML7710, oral carcinoma, Photodynamic therapy, targeted therapies, veterinary / August 2, 2021

Published in: Nanophotonics Authors: Irati Beltrán Hernández, Guillaume C.M. Grinwis, Alessia Di Maggio, Paul M.P. van Bergen en Henegouwen, Wim E. Hennink, Erik Teske, Jan W. Hesselink, Sebastiaan A. van Nimwegen, Jan A. Mol, Sabrina Oliveira

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Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors

Scientific papers / 690 nm, breast cancer, HSP90, in vitro, ML7710, ML8500, PDT, Photodynamic therapy, preclinical, targeted therapies, verteporfin / May 8, 2020

Published in: Communications Biology Authors: Kensuke Kaneko, Takuya Osada, Michael A. Morse, William R. Gwin, Joshua D. Ginzel, Joshua C. Snyder, Xiao-Yi Yang, Cong-Xiao Liu, Márcio A. Diniz, Khaldon Bodoor, Philip F. Hughes, Timothy AJ. Haystead, H. Kim Lyerly

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Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging

Scientific papers / 690 nm, in vitro, in vivo, IRDye700, IRDye700DX, ML7710, PDT, preclinical, targeted cancer PDT, targeted therapies / January 20, 2020

Published in: Theranostics Authors: Henriette S. de Bruijn, Vida Mashayekhi, Tom J.L. Schreurs, Pieter B.A.A. van Driel, Gustav J. Strijkers, Paul J. van Diest, Clemens W.G.M. Lowik, Ann L.B. Seynhaeve, Timo L.M. ten Hagen, Jeanine J. Prompers, Paul M.P. van Bergen en Henegouwen, Dominic J. Robinson, Sabrina Oliveira

Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging Read More »