Tag: in vivo

Modulight Spotlights: LASER-SHARP RESEARCH – March 2026

Laser-sharp Research / chemo resistance, in vitro, in vivo, laser-sharp research, ML7710, ML8500, National Cancer Institute, ovarian cancer, peritoneal carcinoma, photoimmunoconjugates, Photoimmunotherapy, targeted therapies, University of Maryland / March 12, 2026

Modulight Spotlights: LASER-SHARP RESEARCH – March 2026 The development of chemoresistance presents a major challenge in treating peritoneal metastasis, which often occurs in advanced ovarian cancer. To tackle this, Kaitlyn Moore and teams at University of Maryland and National Cancer Institute evaluated photoimmunotherapy as a solution to inhibit a drug efflux pump on cancer cells [...]

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Modulight Spotlights: LASER-SHARP RESEARCH – January 2026

Laser-sharp Research / apoptosis, BPD, cancer, ferroptosis, in vitro, in vivo, laser-sharp research, light activation, ML6600, ovarian cancer, Photoimmunotherapy, photosensitizer / January 28, 2026

Modulight Spotlights: LASER-SHARP RESEARCH – January 2026 The highlight of the month goes to teams of researchers led by Prof. Imran Rizvi at University of North Carolina at Chapel Hill. Their latest publication shows that certain light-activated therapy with BPD photosensitizer and ML6600 laser can induce ferroptosis-like cell death, including formation of lipid peroxides, in

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Modulight Spotlights: LASER-SHARP RESEARCH – December 2025

Laser-sharp Research / imaging, in vitro, in vivo, laser-sharp research, ML6600, multi-wavelength, oxygen, Photodynamic therapy, treatment guidance, treatment monitoring, tumor, ultrasound / December 30, 2025

Deeksha Sankepalle and the group at Tufts University, USA developed an advanced multi-wavelength photoacoustic imaging system. It integrates a pulsed, tunable laser with an ultrasound acquisition platform to provide functional 3D imaging. The system enables real-time, non-invasive, high-resolution imaging of tumor vasculature by tracking oxygen saturation in the tumor.

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Modulight Spotlights: LASER-SHARP RESEARCH – September 2025

Laser-sharp Research / cancer, immunotherapy, in vitro, in vivo, laser-sharp research, ML7710, noveltherapies, Photoimmunotherapy, targeted therapy / September 2, 2025

Published in journal Cancer Medicine, the study shows that the therapeutic effect of photoimmunotherapy is highly dependent on the used light irradiation conditions. Application of the ML7710 medical laser at different durations and powers resulted in highest anti-tumor effect with increased light dose but lowering fluence rate below what is currently used in clinic.

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Interleukin 15 (IL15)-based near-infrared photoimmunotherapy

Scientific papers / 690 nm, in vitro, in vivo, interleukin15, IR700, light activation, ML7710, National Cancer Institute, NIH, NIR, Photoimmunotherapy, PIT, tumor / August 31, 2025

Published in: Cancer Immunology, Immunotherapy Authors: Motofumi Suzuki, Aki Furusawa, Hiroshi Yamamoto, Makoto Kano, Miyu Kano, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi

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Modulight Spotlights: LASER-SHARP RESEARCH – August 2025

Laser-sharp Research / breast cancer, cancer, immunotherapy, in vitro, in vivo, laser-sharp research, ML7710, NIH, Photoimmunotherapy, targeted therapy / August 18, 2025

Laser-sharp research of the month is by Furusawa et al. at Center for Cancer Research, National Cancer Institute, USA. The discovery, published in Annals of Medicine, showed the potential of photoimmunotherapy for treating breast cancer. To expand the usefulness of photoimmunotherapy outside the clinically approved head & neck indication, the new therapy targeted epithelial cell adhesion molecule in breast cancer.

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EpCAM-targeted near-infrared photoimmunotherapy (NIR-PIT) for the treatment of breast cancer

Scientific papers / 690 nm, breast cancer, in vitro, in vivo, IR700, ML7710, NIH, NIR, Photoimmunotherapy / August 12, 2025

Published in: Annals of Medicine Authors: Aki Furusawa ,Seiichiro Takao, Motofumi Suzuki, Makoto Kano, Hiroshi Yamamoto, Miyu Kano, Peter Choyke, Hisataka Kobayashi

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Modulight Spotlights: LASER-SHARP RESEARCH – July 2025

Laser-sharp Research / Cancer therapy, imaging, in vitro, in vivo, laser-sharp research, ML6600, oxygen, photoacoutics, theranostics, treatment monitoring, ultrasound / July 22, 2025

The spotlight of the month goes to Andrew Langley et al. at Tufts University, USA, for their impressive work in leveraging photoacoustic imaging for real-time monitoring of phototherapy. Photoacoustic imaging is 3D, non-ionizing and non-invasive imaging method, based on optical absorption that creates pressure waves detected by ultrasound transducer.

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Heterogeneous tumor blood oxygenation dynamics during phototherapy deciphered with real-time label-free photoacoustic imaging

Scientific papers / 690 nm, in vivo, ML6600, nature, NIH, PDT, Photodynamic therapy / June 4, 2025

Published in: npj Acoustics Authors: Andrew Langley, Allison Sweeney, Ronak T. Shethia, Brooke Bednarke, Faizah Wulandana, Marvin Xavierselvan, Srivalleesha Mallidi

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