Tag: in vivo

Near-infrared Photoimmunotherapy Targeting Canine Mammary Tumors: Comparative Oncology for Overcoming Human Breast Cancer

Scientific papers / 690 nm, breast cancer, in vitro, in vivo, ML7710, NIH, Photoimmunotherapy, tumor / July 29, 2026

Published in: Anticancer Research Authors: Motofumi Suzuki, Aki Furusawa, Hiroshi Yamamoto, Ko Kitamura, Makoto Kano, Miyu Kano, Seiichiro Takao, Yukinari Kato, Amy K. Leblanc, Peter L. Choyke, Hisataka Kobayashi

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Mirabody–IR700: A novel EGFR-targeting platform for photoimmunotherapy

Scientific papers / 690 nm, cancer, cytotoxicity, in vitro, in vivo, IR700, ML7710, Photoimmunotherapy, research, tumor / July 29, 2026

Published in: Biomedicine & Pharmacotherapy Authors: Citra R.A.P. Palangka, Motofumi Suzuki, Ayaka Kanai, Azusa Nitta, Junichi Takagi, Hirofumi Hanaoka

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Understanding Tumor Microenvironment Dynamics and Immune Checkpoint Inhibitor Efficacy Following mEGFR-Targeted Near-Infrared Photoimmunotherapy

Scientific papers / 690 nm, H&N cancer, in vitro, in vivo, intratumoral, ML7710, NIH, Photoimmunotherapy, PIT, tumor / July 10, 2026

Published in: Cancer Letters Authors: Seiichiro Takao, Aki Furusawa, Makoto Kano, Hiroshi Yamamoto, Miyu Kano, Motofumi Suzuki, Hiroshi Fukushima, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi

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Modulight Spotlights: LASER-SHARP RESEARCH – June 2026

Laser-sharp Research / antibiotic resistance, antimicrobial, antimicrobial therapy, appendicitis, disinfection, in vitro, in vivo, intra-abdominal infection, laparoscopic surgery, laser therapy, laser-sharp research, methylene blue, ML7710, PDT, pediatric surgery, perforation, Photodynamic therapy, Photoimmunotherapy, photomedicine, translational research / June 22, 2026

Research teams led by Dr. Timothy Baran and Dr. Nicole Wilson investigated laser-activated methylene blue therapy for perforated appendicitis. Using the ML7710 laser system, the study demonstrated a feasible and safe resistance-independent antimicrobial treatment approach.

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Modulight Spotlights: LASER-SHARP RESEARCH – March 2026

Laser-sharp Research / chemo resistance, in vitro, in vivo, laser-sharp research, ML7710, ML8500, National Cancer Institute, ovarian cancer, peritoneal carcinoma, photoimmunoconjugates, Photoimmunotherapy, targeted therapies, University of Maryland / March 12, 2026

Modulight Spotlights: LASER-SHARP RESEARCH – March 2026 The development of chemoresistance presents a major challenge in treating peritoneal metastasis, which often occurs in advanced ovarian cancer. To tackle this, Kaitlyn Moore and teams at University of Maryland and National Cancer Institute evaluated photoimmunotherapy as a solution to inhibit a drug efflux pump on cancer cells

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Modulight Spotlights: LASER-SHARP RESEARCH – January 2026

Laser-sharp Research / apoptosis, BPD, cancer, ferroptosis, in vitro, in vivo, laser-sharp research, light activation, ML6600, ovarian cancer, Photoimmunotherapy, photosensitizer / January 28, 2026

Modulight Spotlights: LASER-SHARP RESEARCH – January 2026 The highlight of the month goes to teams of researchers led by Prof. Imran Rizvi at University of North Carolina at Chapel Hill. Their latest publication shows that certain light-activated therapy with BPD photosensitizer and ML6600 laser can induce ferroptosis-like cell death, including formation of lipid peroxides, in

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Modulight Spotlights: LASER-SHARP RESEARCH – December 2025

Laser-sharp Research / imaging, in vitro, in vivo, laser-sharp research, ML6600, multi-wavelength, oxygen, Photodynamic therapy, treatment guidance, treatment monitoring, tumor, ultrasound / December 30, 2025

Deeksha Sankepalle and the group at Tufts University, USA developed an advanced multi-wavelength photoacoustic imaging system. It integrates a pulsed, tunable laser with an ultrasound acquisition platform to provide functional 3D imaging. The system enables real-time, non-invasive, high-resolution imaging of tumor vasculature by tracking oxygen saturation in the tumor.

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Modulight Spotlights: LASER-SHARP RESEARCH – September 2025

Laser-sharp Research / cancer, immunotherapy, in vitro, in vivo, IR700, laser-sharp research, ML7710, noveltherapies, Photoimmunotherapy, targeted therapy / September 2, 2025

Published in journal Cancer Medicine, the study shows that the therapeutic effect of photoimmunotherapy is highly dependent on the used light irradiation conditions. Application of the ML7710 medical laser at different durations and powers resulted in highest anti-tumor effect with increased light dose but lowering fluence rate below what is currently used in clinic.

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Interleukin 15 (IL15)-based near-infrared photoimmunotherapy

Scientific papers / 690 nm, in vitro, in vivo, interleukin15, IR700, light activation, ML7710, National Cancer Institute, NIH, NIR, Photoimmunotherapy, PIT, tumor / August 31, 2025

Published in: Cancer Immunology, Immunotherapy Authors: Motofumi Suzuki, Aki Furusawa, Hiroshi Yamamoto, Makoto Kano, Miyu Kano, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi

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