High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies

Published in: Nature Biomedical Engineering

Authors: Katja Haedicke, Lilach Agemy, Murad Omar, Andrei Berezhnoi, Sheryl Roberts, Camila Longo-Machado, Magdalena Skubal, Karan Nagar, Hsiao-Ting Hsu, Kwanghee Kim, Thomas Reiner, Jonathan Coleman, Vasilis Ntziachristos, Avigdor Scherz, Jan Grimm


Raster-scanning optoacoustic mesoscopy (RSOM) was used to monitor vascular responses to vascular-targeted PDT (VTP) with Tookad & ML7710 in mice with subcutaneous xenografts, showing immediate occlusion of tumor vessels, followed by collapse of the entire vasculature. Dual-wavelength RSOM distinguishes hemoglobin from oxyhemoglobin and provides improved spatial resolution that can be used to estimate VTP treatment efficacy .


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