Tag Archives: Tookad

High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies

Published in: Nature Biomedical Engineering Authors: Katja Haedicke, Lilach Agemy, Murad Omar, Andrei Berezhnoi, Sheryl Roberts, Camila Longo-Machado, Magdalena Skubal, Karan Nagar, Hsiao-Ting Hsu, Kwanghee Kim, Thomas Reiner, Jonathan Coleman, Vasilis Ntziachristos, Avigdor Scherz, Jan Grimm    Published in: Nature Biomedical Engineering Authors: Katja Haedicke, Lilach Agemy, Murad Omar, Andrei Berezhnoi, Sheryl Roberts, Camila Longo-Machado, Magdalena Skubal, Karan Nagar, Hsiao-Ting Hsu, Kwanghee Kim, Thomas Reiner, Jonathan Coleman, Vasilis Ntziachristos, Avigdor Scherz, Jan Grimm   Raster-scanning optoacoustic mesoscopy (RSOM) was used to monitor vascular responses to vascular-targeted PDT (VTP) with Tookad & ML7710 in mice with subcutaneous xenografts, showing immediate occlusion of tumor vessels, followed by collapse of the entire vasculature. Dual-wavelength RSOM distinguishes hemoglobin from oxyhemoglobin and provides improved spatial resolution that Continue reading →

WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice

Published in: Theranostics Authors: Volker Neuschmelting, Kwanghee Kim, Jaber Malekzadeh-Najafabadi, Sylvia Jebiwott, Jaya Prakash, Avigdor Scherz, Jonathan A. Coleman, Moritz F. Kircher, Vasilis Ntziachristos    Published in: Theranostics Authors: Volker Neuschmelting, Kwanghee Kim, Jaber Malekzadeh-Najafabadi, Sylvia Jebiwott, Jaya Prakash, Avigdor Scherz, Jonathan A. Coleman, Moritz F. Kircher, Vasilis Ntziachristos   The research group studied vascular-targeted photodynamic therapy (VTP). They used laser to activate Tookad (WST11) photosensitizer in VTP using renal cancer mouse model to develop multispectral optoacoustic tomography (MSOT) monitoring method for VTP.   Read the article here