Tag: ML8500

Modulight Spotlights: LASER-SHARP RESEARCH – November 2025

Laser-sharp Research / cancer, chemotherapy, drug delivery, glioblastoma, in vitro, laser-sharp research, ML8500, multidrug resistance, photoactivated chemotherapy, Photoimmunotherapy, preclinical, therapy resistance, tumor, University of Maryland, verteporfin / November 19, 2025

Modulight Spotlights: LASER-SHARP RESEARCH – November 2025 We are delighted to highlight new exciting study by Rahman et al. from Dr. Huang-Chiao Huang’s lab at University of Maryland. Multidrug resistance remains a significant barrier to successful chemotherapy outcomes for cancer patients, often caused by active pumping of chemotherapeutics outside of cancer cells. Hence, the team [...]

Modulight Spotlights: LASER-SHARP RESEARCH – November 2025 Read More »

Harnessing liposomal nanocellulose hydrogel for NIR-light driven on-demand drug delivery

Scientific papers / 808 nm, drug delivery, drug distribution, hydrogels, in vitro, liposomes, ML8500, nanoparticles, PDT, University of Helsinki / April 4, 2025

Published in: Carbohydrate Polymer Technologies and Applications Authors: Puja Gangurde, Zahra Gounani, Jacopo Zini, Roberta Teixeira Polez, Monika Osterberg, Patrick Lauren, Tatu Lajunen, Timo Laaksonen

Harnessing liposomal nanocellulose hydrogel for NIR-light driven on-demand drug delivery Read More »

ML8500 – automatic biomedical illumination

product pages / biomedical, illumination, illumination kit, laser illumination, liposomes, microplates, ML8500, petri dish, photosensitizer, sequential, well plates / March 27, 2025

ML8500 Automatic biomedical illumination system ML8500 is the world's most versatile illumination device for in-vitro studies. ML8500 can support up to 7 different wavelengths simultaneously, flexible control of illumination parameters, and built-in incubation chamber for cells studies in normoxic and hypoxic conditions. Researcher operating ML8500 at Modulight's Biomedical Laboratories Request quotation! Automatic system for illuminating

ML8500 – automatic biomedical illumination Read More »

Modulight Spotlights: LASER-SHARP RESEARCH – October 2024

Laser-sharp Research / cancer treatment, drug delivery, hypoxia, laser-sharp research, light activation, liposomes, ML8500, normoxia, University of Helsinki / October 24, 2024

Modulight Spotlights: LASER-SHARP RESEARCH – October 2024 This month, we are highlighting new findings published in RSC Materials Advances by Olga Lem, Roosa Kekki and researchers at Pharmaceutical Nanotechnology research group and Tampere University. The study provides key insights into the role of lipid oxidation in cargo release from light-activated liposomes. These spherical lipid vesicles can

Modulight Spotlights: LASER-SHARP RESEARCH – October 2024 Read More »

The role of lipid oxidation pathway in reactive oxygen species-mediated cargo release from liposomes

Scientific papers / 630 nm, hypoxia, illumination, liposomes, ML8500, normoxia, oxygen, ROS detection / October 12, 2024

Published in: Materials Advances Authors: Olga Lem, Roosa Kekki, Artturi Koivuniemi, Alexander Efimov, Timo Laaksonen, Nikita Durandin

The role of lipid oxidation pathway in reactive oxygen species-mediated cargo release from liposomes Read More »

Modulight Spotlights: LASER-SHARP RESEARCH – September 2024

Laser-sharp Research / cancer, cancer treatment, drug resistance, in vitro, laser-sharp research, ML8500, photosensitizer, pumps, therapy resistance / September 23, 2024

University of Maryland and Modulight have published together a new research study about the mechanisms of cancer drug resistance. Drug resistance is a leading cause of treatment failure and often has dramatic consequences for survival of cancer patients.

Modulight Spotlights: LASER-SHARP RESEARCH – September 2024 Read More »

Ru(II) Oligothienyl Complexes with Fluorinated Ligands: Photophysical, Electrochemical, and Photobiological Properties

Scientific papers / 525 nm, 630 nm, 753 nm, cancer, hypoxia, in vitro, ML8500, PDT, photosensitizer, phototherapy, University of Texas at Arlington / May 10, 2024

Published in: Inorganic Chemistry Authors: Houston D. Cole, Abbas Vali, John A. Roque III, Ge Shi, Alisher Talgatov, Gurleen Kaur, Antonio Francés-Monerris, Marta E. Alberto, Colin G. Cameron, Sherri A. McFarland

Ru(II) Oligothienyl Complexes with Fluorinated Ligands: Photophysical, Electrochemical, and Photobiological Properties Read More »

Development of thermosensitive liposomes with the help of ML8500

Application Note / 808 nm, application note, drug delivery, drug discovery, illumination system, in vitro, indocyanine green, light activation, liposomes, ML6600, ML8500, MLAKIT, University of Helsinki / March 13, 2024

Background The proper delivery and release of therapeutic drugs to a specific site or cell type is one of the main challenges in the treatment of diseases. Liposomes, which are vesicles composed of lipids, serve as carriers for drug delivery thanks to their long circulation time. This results to reduced toxicity in healthy tissues and

Development of thermosensitive liposomes with the help of ML8500 Read More »

Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids

Scientific papers / in vitro, lasers in science, ML8500, photosensitizer, well plate / February 6, 2024

Published in: Cell & Bioscience Authors: Aaron Sorrin, Anika Dasgupta, Kathryn McNaughton, Carla Arnau Del Valle, Keri Zhou, Cindy Liu, Dana M. Roque & Huang Chiao Huang Within the last decade, poly(ADP-ribose) polymerase inhibitors (PARPi) have emerged in the clinic as an effective treatment for numerous malignancies. Preclinical data have demonstrated powerful combination effects of PARPi

Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids Read More »