Author Archives: Modulight Content

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Modulight wants to share high-quality scientific publications, white papers, application notes, and other articles. The articles shared are courtesy of the authoring researchers and groups and we're thankful for giving us the permission to honor their work this way. If you have something to share please drop us a line (see the contact form at Contact Us section).

Modulight Spotlights: LASER-SHARP RESEARCH – August 2024

August 7, 2024 by Modulight Content
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                    Modulight Spotlights: LASER-SHARP RESEARCH – August 2024 This month’s research highlight goes to Hirofumi Hanaoka and the team at Kansai Medical University, Japan. They developed a new laser fiber and method for illumination of narrow cavities, such as esophagus. With typical laser fibers, it is difficult to precisely illuminate target tumor in a narrow space at an oblique angle, since there is not enough space for fiber bending. The new lateral (side) emitting laser fiber was developed and evaluated for near-infrared photoimmunotherapy, which combines light, Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – July 2024

July 26, 2024 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – July 2024 Exciting new findings in prostate cancer research were reported by Xinning Wang and team at Case Western University, Comprehensive Cancer Center. Prostate cancer is the most common cancer among men and despite typically good prognosis, is a leading cause of cancer-related death. In the new study, the team combined chemotherapy with a novel light-activated, theranostic agent to enable targeted imaging and treatment of prostate cancer. Using ML7710 laser at 672 nm for activation of the drug, they were Continue reading →

Age-related Macular Degeneration (AMD)

June 27, 2024 by Modulight Content
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Age-related Macular Degeneration (AMD) Age-related Macular Degeneration (AMD) is a disease causing choroidal neovascularization (CNV) and consequent irreversible damage in the macula. AMD is classified into dry (atrophic) and wet (exudative) forms, with the latter causing faster vision loss and being the leading cause of blindness in people over 65. Introduction to AMD Age-related Macular Degeneration (AMD) is one of the leading causes for  visual impairment. AMD is charactirized by development of Choroidal neovascularization (CNV) and consequent irreversible damage in the macula. CNV means abnormal Continue reading →

Photodynamic Therapy for Cancer Treatment – Review Article by Nature

June 20, 2024 by Modulight Content
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 Modulight Corp., a leader in innovative laser solutions, is proud to announce a significant contribution to the field of cancer treatment through the publication of a comprehensive review on Photodynamic Therapy (PDT) in Nature Reviews Bioengineering. This review article, co-authored by Modulight’s CTO Dr. Petteri Uusimaa, alongside several other leading experts, highlights the transformative potential of PDT in cancer treatment, priming, and imaging. The review article, titled “Engineering Photodynamics for Treatment, Priming, and Imaging”, explores the advanced applications of PDT, a photochemistry-based treatment approach that Continue reading →

Engineering Photodynamics for Treatment, Priming and Imaging

June 19, 2024 by Modulight Content
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 Published in: Nature Reviews Bioengineering Authors: Girgis Obaid, University of Texas at Dallas Jonathan P. Celli, University of Massachusetts Boston Mans Broekgaarden, Grenoble Alpes University Anne-Laure Bulin, Grenoble Alpes University Petteri Uusimaa, Modulight Corporation Brian Pogue, University of Wisconsin School of Medicine Tayyaba Hasan, Harvard Medical School Huang-Chiao Huang, University of Maryland   The review article explores the advanced applications of PDT, a photochemistry-based treatment approach that utilizes light-activated photosensitizers to generate reactive oxygen species for localized cellular cytotoxicity. The paper discusses the underlying mechanisms Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – June 2024

June 12, 2024 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – June 2024 A promising new therapy against viruses was developed at University of Manitoba and Theralase Technologies. Infectious agents are a global problem, causing millions of deaths every year. The study evaluated antiviral effectiveness of a cancer drug (Ruvidar), which is currently in clinical development for bladder cancer. When this drug was activated with green laser using Modulight’s ML6600, it resulted in a rapid elimination of many different human viruses. Impressively, it was >99% effective at low doses in inactivating human coronavirus, influenza Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – May 2024

May 23, 2024 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – May 2024 A new publication by Professor Bryan Spring and his team at Northeastern University has shown promising results for improved photoimmunotherapy protocols using patient-derived ovarian cancer cells. Using Modulight’s ML6000-series laser as part of the new protocol, they successfully minimized non-specific damage to cells that was caused by a small fraction of non-covalently bound (free) photosensitive drug, which is typically cleared in vivo by lymph and blood flow. They also showed the importance of using more biologically relevant cancer Continue reading →

ML6600 Multiwavelength Distributed Bragg Reflector Laser Platform for Quantum Applications

May 6, 2024 by Modulight Content
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Modulight ML6600 Distributed Bragg Reflector laser cores are available at various wavelengths – 650 nm, 760 nm, 780 nm, 785 nm, 795 nm, and 935 nm – relevant to quantum and spectroscopy applications. The fully in-house manufactured laser diodes exhibit reliable high-power operation with down to below 500 kHz linewidth. Designed for highest-quality mechanical, optical and acoustical isolation, and integrated with ML6600 platform’s ultra-low-noise current drivers and accurate temperature controllers, these laser cores show top-notch performance. Both free-space output and single-mode polarization maintaining fiber are Continue reading →Modulight ML6600 Distributed Bragg Reflector laser cores are available at various wavelengths - 650 nm, 760 nm, 780 nm, 785 nm, 795 nm, and 935 nm - relevant to quantum and spectroscopy applications. The fully in-house manufactured laser diodes exhibit reliable high-power operation with down to below 500 kHz linewidth. Designed for highest-quality mechanical, optical and acoustical isolation, and integrated with ML6600 platform’s ultra-low-noise current drivers and accurate temperature controllers, these laser cores show top-notch performance. Both free-space output and single-mode polarization maintaining fiber are Continue reading →

ML6600 Narrow linewidth VECSEL for photoionization of Ba for trapped ion computing

May 6, 2024 by Modulight Content
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Modulight’s in-house vertical-external-cavity surface-emitting laser (VECSEL) technology integration into ML6600 laser cores paves the way for Barium trapped ion applications at wavelengths 493 nm, 532 nm and 553 nm, featuring free-running linewidth of <100 kHz with Watt-level emission. Linewidth can be further narrowed using linewidth narrowing techniques such as Pound-Drever Hall method and a stable reference. Modulight ML6600 VECSEL laser platform offers scalable and tunable high-power single-frequency emission pumped by inexpensive multimode lasers. VECSELs possess several advantages as a narrow linewidth laser platform. The external Continue reading →Modulight’s in-house vertical-external-cavity surface-emitting laser (VECSEL) technology integration into ML6600 laser cores paves the way for Barium trapped ion applications at wavelengths 493 nm, 532 nm and 553 nm, featuring free-running linewidth of <100 kHz with Watt-level emission. Linewidth can be further narrowed using linewidth narrowing techniques such as Pound-Drever Hall method and a stable reference. Modulight ML6600 VECSEL laser platform offers scalable and tunable high-power single-frequency emission pumped by inexpensive multimode lasers. VECSELs possess several advantages as a narrow linewidth laser platform. The external Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – April 2024

April 10, 2024 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – April 2024 First-in-human, phase 1 clinical trial results with ML7710 have been published in a renowned journal Radiology by Timothy Baran and team at University of Rochester Medical Center. The trial investigated treatment of deep tissue abscesses using photodynamic therapy with methylene blue and ML7710 laser. Abscesses are painful collection of pus, usually caused by a bacterial infection. Standard treatment is abscess drainage and antibiotics, however treatment responses vary widely and are linked to prolonged hospital stay, costs, and patient discomfort, as well as increasing concerns for antibiotic-resistance. The trial in 18 Continue reading →