Tag Archives: laser-sharp research

Modulight Spotlights: LASER-SHARP RESEARCH – November 2023

November 14, 2023 by Modulight
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 Modulight Spotlights: LASER-SHARP RESEARCH – November 2023 The development of modern antibiotics is recognized as one of the major achievements of medicine and has saved millions of lives. However, many infectious agents have developed resistance to antibiotics over time, and defining new antibiotic targets has been difficult since very few genes are essential for pathogens. To combat this growing problem, Professor Timothy Haystead’s team at Duke University developed a novel light-based antimicrobial strategy that targets non-essential enzyme on the surface of bacteria. Light activation was Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – October 2023

October 12, 2023 by Modulight
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 Modulight Spotlights: LASER-SHARP RESEARCH – October 2023 ​Antimicrobial resistance is an increasing healthcare problem, with new effective treatment strategies urgently needed. Professor Mitsunaga and team at The Jikei University Medical School, Japan, describe a promising treatment called photoimmuno-antimicrobial strategy (PIAS) in a new Nature publication. Detailed instructions how to design and implement the treatment are given, with Modulight’s ML7710 and ML6600 series lasers validated for drug activation in the protocol. This treatment enables targeted elimination of different microbes, regardless of the species or drug resistance Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – September 2023

September 12, 2023 by Modulight
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 Modulight Spotlights: LASER-SHARP RESEARCH – September 2023 Head & neck cancer is world’s sixth most common cancer, with increasing incidence and poor survival. A new study by P. Enzian & R. Rahmanzadeh at University of Lübeck, studied combining chemotherapy with photochemical internalization for more effective H&N cancer treatment in vitro. Photochemical internalization using photosensitizer fimaporfin, activated with Modulight’s ML6600 laser, was shown to increase drug’s efficacy by means of better drug delivery inside the cells. As a result, tumor cell death was achieved using 20-fold Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – April 2023

April 13, 2023 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – April 2023 Metastases remain the leading cause of cancer-related deaths worldwide. To combat this problem, Ruben V. Huis in ‘t Veld et al. combined immune checkpoint inhibitors with a light-activated virus-drug conjugate in their preclinical study. As published in Cancer Immunology, Immunotherapy journal, the combination was effective against metastatic tumors and in most cases even resulted in complete responses to therapy. ​​ Read original publication   Modulight is very happy to be supporting this research. We would like to deliver our Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – February 2023

February 23, 2023 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – February 2023 The nomination for Laser-Sharp Research goes to Mäki-Mikola et al. at University of Helsinki for their development of a dynamic cell culturing platform for light-activation studies. The developed platform has a flow chamber connected to a peristaltic pump, which creates a flow that resembles the natural fluid flow at the cell surfaces. ML6500 laser was used to release calcein from liposomes to validate the suitability of the platform for light-triggered drug release. Compared to traditional static cell culture Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – September 2022

September 8, 2022 by Modulight Content
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   Modulight Spotlights: LASER-SHARP RESEARCH – September 2022 Mesothelioma is a form of pleural cancer originating primarily from asbestos exposure. There is currently no curative treatment available for this cancer and its prevalence is on the rise, hence new treatment options are urgently needed. To answer this need, Professors Timothy C. Zhu and Keith Cengel with their teams at University of Pennsylvania have for several years studied intraoperative photodynamic therapy, where photosensitive drug is locally activated with laser light, as a potential new adjunctive treatment for this aggressive disease. Their most recent Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – August 2022

August 10, 2022 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – August 2022 Impressive research on head & neck cancer was published by Obaid Lab for molecular imaging and optical nanotherapeutics, at University of Texas, Dallas. The group used Modulight’s ML6500 for a subtherapeutic modulation of tumor microenvironment of H&N. This significantly improved delivery of molecular imaging agent to the tumors as well as improved diagnostic accuracy in detecting tumor tissue by fluorescence. Since incomplete resection and consequent recurrences are common problem with current H&N cancer treatment, this discovery answers unmet Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – July 2022

July 11, 2022 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – July 2022 Modulight congratulates Dr. Makoto Mitsunaga et al. Jikei University School of Medicine for publishing their promising results in Communications Biology journal. The team developed a next-generation light-based approach to tackle pathogens, called photoimmuno-antimicrobial strategy (PIAS). This technology was shown to eliminate a broad spectrum of different classes of pathogens, such as viruses, fungi, and bacteria. Unlike antibiotics, PIAS was also effective against drug-resistant pathogens and didn’t damage natural, beneficial microbiota in the host’s tissues. As COVID-19 pandemic and Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – February 2022

March 2, 2022 by Modulight Content
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   Modulight Spotlights: LASER-SHARP RESEARCH – February 2022 Photocure’s blue light cystoscopy is a routine procedure in the management of bladder cancer as it results in better tumor visualization and removal. However, this study found that the positive effects of blue light cystoscopy could extend beyond visualization and result in the induction of systemic antitumor immunity, which can be further boosted with immune checkpoint inhibitors. Modulight nominated this study because bladder cancer is highly recurring and progressive disease with more than 200,000 deaths worldwide annually. Thus, Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – November 2021

December 7, 2021 by Modulight Content
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     Modulight Spotlights: LASER-SHARP RESEARCH – November 2021 Dr. Aaron Sorrin and researchers at the University of Maryland found a new potential combination therapy for ovarian cancer. This combination includes a novel light-based technology, called photodynamic priming, and a targeted therapeutic against a specific cancer cell receptor, effectively suppressing invasion of cancer cells. Modulight’s scientific board wanted to highlight this research especially because novel therapeutic solutions are urgently needed against this aggressive disease, which despite the best possible current therapies, recurs in most patients leading to Continue reading →