Fluorescence-guided photoimmunotherapy for peritoneal carcinomatosis

Published in: SPIE BIOS 2024

Authors: Barry Liang, Sumiao Pang, Robert Perttilä, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Nada Fadul, Idrisa Rahman, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang

Peritoneal metastasis, incomplete resection, and drug resistance render advanced-stage ovarian cancer virtually incurable with current surgical and chemotherapy approaches. Photoimmunotherapy is increasingly used to treat unresectable metastases, but many innovations are lost in translation due to heterogeneous treatment effects. This study integrates targeted nanotechnology, fluorescence-guided intervention, and a medical laser system to improve the safety, efficacy, and consistency of photoimmunotherapy for peritoneal metastases.


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