This month we are highlighting exciting findings by S. Takao et al. from Hisataka Kobayashi’s lab at the National Cancer Institute, NIH. Published in Cancer Letters, the study shows that near-infrared photoimmunotherapy can destroy cancer cells by targeting intercellular adhesion molecule-1.
Modulight Spotlights: LASER-SHARP RESEARCH – October 2025 Read More »
Published in journal Cancer Medicine, the study shows that the therapeutic effect of photoimmunotherapy is highly dependent on the used light irradiation conditions. Application of the ML7710 medical laser at different durations and powers resulted in highest anti-tumor effect with increased light dose but lowering fluence rate below what is currently used in clinic.
Modulight Spotlights: LASER-SHARP RESEARCH – September 2025 Read More »
Published in: Cancer Immunology, Immunotherapy Authors: Motofumi Suzuki, Aki Furusawa, Hiroshi Yamamoto, Makoto Kano, Miyu Kano, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi
Interleukin 15 (IL15)-based near-infrared photoimmunotherapy Read More »
Laser-sharp research of the month is by Furusawa et al. at Center for Cancer Research, National Cancer Institute, USA. The discovery, published in Annals of Medicine, showed the potential of photoimmunotherapy for treating breast cancer. To expand the usefulness of photoimmunotherapy outside the clinically approved head & neck indication, the new therapy targeted epithelial cell adhesion molecule in breast cancer.
Modulight Spotlights: LASER-SHARP RESEARCH – August 2025 Read More »
Published in: Annals of Medicine Authors: Aki Furusawa ,Seiichiro Takao, Motofumi Suzuki, Makoto Kano, Hiroshi Yamamoto, Miyu Kano, Peter Choyke, Hisataka Kobayashi
Gokalp et al. from University of Massachusetts and Tufts University constructed an innovative liquid metal nanoparticle platform, which has tumor cell targeting and enhanced encapsulation of verteporfin. Charactierization in vitro with the help of ML6600 laser showed effective in vitro phototoxicity.
Modulight Spotlights: LASER-SHARP RESEARCH – April 2025 Read More »
Published in: Cancer Science Authors: Hiroshi Yamamoto, Aki Furusawa, Hiroshi Fukushima, Seiichiro Takao, Motofumi Suzuki, Makoto Kano, Miyu Kano, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi
Published in: International Journal of Cancer Authors: Hiroshi Fukushima, Seiichiro Takao, Aki Furusawa, Motofumi Suzuki, Youfeng Yang, Christopher J. Ricketts, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Miyu Kano, Mark W. Ball, Peter L. Choyke, W. Marston Linehan, Hisataka Kobayashi
Published in: Cancer Immunology, Immunotherapy Authors: Seiichiro Takao, Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Shuhei Okuyama, Makoto Kano, Hiroshi Yamamoto, Motofumi Suzuki, Miyu Kano, Peter L. Choyke, Hisataka Kobayashi
