Tag Archives: Photoimmunotherapy

Modulight Spotlights: LASER-SHARP RESEARCH – May 2024

 Modulight Spotlights: LASER-SHARP RESEARCH – May 2024 A new publication by Professor Bryan Spring and his team at Northeastern University has shown promising results for improved photoimmunotherapy protocols using patient-derived ovarian cancer cells. Using Modulight’s ML6000-series laser as part of the new protocol, they successfully minimized non-specific damage to cells that was caused by a small fraction of non-covalently bound (free) photosensitive drug, which is typically cleared in vivo by lymph and blood flow. They also showed the importance of using more biologically relevant cancer Continue reading →

Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells

Published in: eBioMedicine Authors: Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S. Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L. Choyke, Martin J. Schnermann, Hisataka Kobayashi  Published in: eBioMedicine Authors: Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S. Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L. Choyke, Martin J. Schnermann, Hisataka Kobayashi A new method called phototruncation-assisted cell tracking (PACT) can be used to noninvasively track migration of immune cells to understand anti-cancer immunity mechanisms. PACT is based on irreversible photo-induced truncation reaction, transforming Cy7 into Cy5 when exposed to NIR light (780 nm). PACT was used in this study to monitor spatiotemporal migration of immune cells between tumor and Continue reading →

Fluorescence-guided photoimmunotherapy for peritoneal carcinomatosis

Published in: SPIE BIOS 2024 Authors: Barry Liang, Sumiao Pang, Robert Perttilä, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Nada Fadul, Idrisa Rahman, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang  Published in: SPIE BIOS 2024 Authors: Barry Liang, Sumiao Pang, Robert Perttilä, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron Sorrin, Nada Fadul, Idrisa Rahman, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang Peritoneal metastasis, incomplete resection, and drug resistance render advanced-stage ovarian cancer virtually incurable with current surgical and chemotherapy approaches. Photoimmunotherapy is increasingly used to treat unresectable metastases, but many innovations are lost in translation due to heterogeneous treatment effects. This study integrates targeted nanotechnology, fluorescence-guided intervention, and a medical laser system to Continue reading →

Automated drug detection and dynamic measurement prioritization with medical laser platform

Published in: SPIE BIOS 2024 Authors: Henri Auvinen, Lassi Luokkanen, Zoe Ylöniemi, Natalia Leinonen, Ana Colucci, Petteri Uusimaa  Published in: SPIE BIOS 2024 Authors: Henri Auvinen, Lassi Luokkanen, Zoe Ylöniemi, Natalia Leinonen, Ana Colucci, Petteri Uusimaa Monitoring treatment through spectral data enables adjusting treatment in real-time for each patient separately, in line with the trend for personalized medicine. Modulight ML7710 laser can simultaneously measure spectral data from up to 8 different locations in tumor tissue. The laser with this optical monitoring feature is currently being tested in glioblastoma trials in Germany where patients receive photoimmunotherapy and treatment is tailored through spectral monitoring of Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – October 2023

 Modulight Spotlights: LASER-SHARP RESEARCH – October 2023 ​Antimicrobial resistance is an increasing healthcare problem, with new effective treatment strategies urgently needed. Professor Mitsunaga and team at The Jikei University Medical School, Japan, describe a promising treatment called photoimmuno-antimicrobial strategy (PIAS) in a new Nature publication. Detailed instructions how to design and implement the treatment are given, with Modulight’s ML7710 and ML6600 series lasers validated for drug activation in the protocol. This treatment enables targeted elimination of different microbes, regardless of the species or drug resistance Continue reading →

Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses

Published in: Nature Protocols Authors: Tadayuki Iwase, Kimihiro Ito, Takashi Nishimura, Kei Miyakawa, Akihide Ryo, Hisataka Kobayashi, Makoto Mitsunaga The Jikei University School of Medicine  Published in: Nature Protocols Authors: Tadayuki Iwase, Kimihiro Ito, Takashi Nishimura, Kei Miyakawa, Akihide Ryo, Hisataka Kobayashi, Makoto Mitsunaga The Jikei University School of Medicine Microbial pathogens, including bacteria, fungi and viruses, can develop resistance to clinically used drugs; therefore, finding new therapeutic agents is an ongoing challenge. Recently, we reported the photoimmuno-antimicrobial strategy (PIAS), a type of photoimmunotechnology, that enables molecularly targeted elimination of a wide range of microbes, including the viral pathogen severe acute respiratory syndrome coronavirus 2 and the multidrug-resistant bacterial pathogen Continue reading →

Pioneering study confirms benefits of Modulight’s technology and photoimmunotherapy for ovarian cancer

A study published in Science Advances has for the first time scientifically demonstrated the potential of fluorescence-guided photoimmunotherapy enabled with Modulight’s laser platform and cloud technology. The study, a collaboration between the University of Maryland (UMD) and Modulight, confirms the benefits of targeted nanomedicine, Modulight’s medical laser system, and fluorescence-guided intervention in both achieving better treatment outcomes and predicting tumor response. “We have already published over a hundred scientific articles on our website from world-leading research groups that have used Modulight products in their studies. This Continue reading →A study published in Science Advances has for the first time scientifically demonstrated the potential of fluorescence-guided photoimmunotherapy enabled with Modulight's laser platform and cloud technology. The study, a collaboration between the University of Maryland (UMD) and Modulight, confirms the benefits of targeted nanomedicine, Modulight’s medical laser system, and fluorescence-guided intervention in both achieving better treatment outcomes and predicting tumor response. "We have already published over a hundred scientific articles on our website from world-leading research groups that have used Modulight products in their studies. This Continue reading →

Fluorescence-guided photoimmunotherapy using targeted nanotechnology and ML7710 to manage peritoneal carcinomatosis

Published in: Science Advances Authors: Barry J. Liang(1,2), Sumiao Pang(1), Robert Perttilä(3), Chen-Hua Ma(1), Payal Srivastava(1), Brandon Gaitan(1), Aaron J. Sorrin (1), Nada Fadul(1), Zoe Ylöniemi(3), Dana M. Roque(4,5), Tayyaba Hasan(6), Petteri Uusimaa(3), Huang-Chiao Huang(1,4*) (1) Fischell Department of Bioengineering, University of Maryland (2) Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (3) Modulight Corp., Finland (4) Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine (5) Department of Obstetrics, Gynecology and Reproductive Sciences, University Continue reading →Published in: Science Advances Authors: Barry J. Liang(1,2), Sumiao Pang(1), Robert Perttilä(3), Chen-Hua Ma(1), Payal Srivastava(1), Brandon Gaitan(1), Aaron J. Sorrin (1), Nada Fadul(1), Zoe Ylöniemi(3), Dana M. Roque(4,5), Tayyaba Hasan(6), Petteri Uusimaa(3), Huang-Chiao Huang(1,4*) (1) Fischell Department of Bioengineering, University of Maryland (2) Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (3) Modulight Corp., Finland (4) Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine (5) Department of Obstetrics, Gynecology and Reproductive Sciences, University Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – August 2023

 Modulight Spotlights: LASER-SHARP RESEARCH – August 2023 Interleukin 15 (IL-15) is promising candidate for cancer immunotherapy, since it is an inducer of differentiation and proliferation of killer T cells and NK cells. A new study by Fukushima et al. at NCI, published in Molecular Cancer Therapeutics, shows increase in therapeutic efficacy in vivo when IL15 was combined with photoimmunotherapy using ML7710 laser system. Intratumoral injection of IL-15 also boosted the immune responses against both the primary tumor as well as abscopal effect eradicating distant, untreated tumor.​ ​​ Read original publication Modulight Continue reading →

Intratumoral interleukin-15 improves efficacy of near-infrared photoimmunotherapy

Published in: Molecular Cancer Therapeutics Authors: Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Hiroaki Wakiyama, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi    Published in: Molecular Cancer Therapeutics Authors: Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Hiroaki Wakiyama, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi   Interleukin 15 (IL-15) is inducer of differentiation and proliferation of CD8+ T cells and NK cells and thus promising candidate for cancer immunotherapy. This study showed therapeutic efficacy increase in vivo when IL15 was combined with cancer cell-targeted photoimmunotherapy using ML7710 laser system. Intratumoral injection of IL-15 was more effective than intraperitoneal in suppressing tumor growth and inducing intratumoral immune responses, Continue reading →