Tag Archives: liposomes

Modulight Spotlights: LASER-SHARP RESEARCH – October 2024

October 24, 2024 by Modulight Content
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Modulight Spotlights: LASER-SHARP RESEARCH – October 2024 This month, we are highlighting new findings published in RSC Materials Advances by Olga Lem, Roosa Kekki and researchers at Pharmaceutical Nanotechnology research group and Tampere University. The study provides key insights into the role of lipid oxidation in cargo release from light-activated liposomes. These spherical lipid vesicles can be controlled by light to provide time- and site-specific drug delivery, for example for cancer treatment. Red light provides a non-invasive, selective, and safe trigger for releasing liposomal cargo. Modulight’s Continue reading →

Development of thermosensitive liposomes with the help of ML8500

March 13, 2024 by Modulight Content
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Background The proper delivery and release of therapeutic drugs to a specific site or cell type is one of the main challenges in the treatment of diseases. Liposomes, which are vesicles composed of lipids, serve as carriers for drug delivery thanks to their long circulation time. This results to reduced toxicity in healthy tissues and improved therapeutic efficacy of encapsulated drugs. However, conventional liposomes can often be even too stabile, leading to insufficient drug release at the target site. Light activation can offer a solution Continue reading →Customer case Pharmaceutical Nanotechnology Group at University of Helsinki is specialized in top-level pharmaceutical research. Led by Professor Timo Laaksonen, the group focuses on controlled drug release and delivery using modern methods and materials. Particular interest lies in using light to both monitor nanomaterial behavior and to trigger e.g. drug release processes. Modulight products: ML8500, ML6600, MLAKIT   Prof. Timo Laaksonen Dr. Tatu Lajunen Laser use: Light-triggered drug release studies from light-activated liposomes. ML8500 with 808 nm wavelength was used to induce the release of calcein from liposomes under Continue reading →

Development of Robust Cationic Light-Activated Thermosensitive Liposomes: Choosing the Right Lipids

October 24, 2023 by Modulight Content
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Published in: Molecular Pharmaceutics Authors: Puja Gangurde, Mohammad Mahmoudzadeh, Zahra Gounani, Artturi Koivuniemi, Patrick Laurén, Tatu Lajunen, Timo Laaksonen  Published in: Molecular Pharmaceutics Authors: Puja Gangurde, Mohammad Mahmoudzadeh, Zahra Gounani, Artturi Koivuniemi, Patrick Laurén, Tatu Lajunen, Timo Laaksonen The study investigated the impact of different lipids on liposome stability. It was found that substituting unsaturated lipid with equal amount of saturated lipid, resulted in stable liposomes that were highly responsive to light triggered release. ML8500 was used for light-activated release of calcein from liposomes.   Read the article here

Transient fluid flow improves photoimmunoconjugate delivery and photoimmunotherapy efficacy

June 26, 2023 by Modulight Content
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Published in: iScience Authors: Aaron J. Sorrin, Keri Zhou, Katherine May, Cindy Liu, Kathryn McNaughton, Idrisa Rahman, Barry J. Liang, Imran Rizvi, Dana M. Roque, Huang-Chiao Huang    Published in: iScience Authors: Aaron J. Sorrin, Keri Zhou, Katherine May, Cindy Liu, Kathryn McNaughton, Idrisa Rahman, Barry J. Liang, Imran Rizvi, Dana M. Roque, Huang-Chiao Huang   The study showed that fluid flow induced shear stress increased the photocytotoxicity of different photosensitizers tested (BPD, PIC, PIC-coated liposome) against ovarian cancer cells. The cellular delivery of photosensitizers doubled compared to static conditions. Modulight laser was used for PDT activation together with photosensitizer(s). Circulating drugs in the peritoneal cavity is an effective strategy for advanced ovarian Continue reading →

Light-induced cytotoxicity in cells utilizing an automated well plate illuminator

March 7, 2023 by Modulight Content
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Presented in: SPIE BIOS 2023 Authors: Laura Vesala, Robert Perttilä, Elias Kokko, Johannes Kivelä, Lasse Orsila, Petteri Uusimaa    Presented in: SPIE BIOS 2023 Authors: Laura Vesala, Robert Perttilä, Elias Kokko, Johannes Kivelä, Lasse Orsila, Petteri Uusimaa   Delivering therapeutic drug molecules to the target site and releasing the cargo site-specifically is of major interest in biomedicine. To carry and release drugs to specific target tissues, different nanotechnology approaches have been utilized. These include light-sensitive liposomal carriers, which have been engineered to release cargo from their aqueous cores when illuminated by certain wavelengths of laser light. To study drug release parameters in vitro, Modulight Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – February 2023

February 23, 2023 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – February 2023 The nomination for Laser-Sharp Research goes to Mäki-Mikola et al. at University of Helsinki for their development of a dynamic cell culturing platform for light-activation studies. The developed platform has a flow chamber connected to a peristaltic pump, which creates a flow that resembles the natural fluid flow at the cell surfaces. ML6500 laser was used to release calcein from liposomes to validate the suitability of the platform for light-triggered drug release. Compared to traditional static cell culture Continue reading →

Light-induced drug delivery with indocyanine green liposomes

August 30, 2022 by Modulight Content
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Introduction to light-controlled drug delivery systems Study description It is important that light-triggered liposomes efficiently release their contents, while the liposome stability should be maintained in the absence of laser light. The aim of this study is to determine how liposomal stability and drug release are affected by liposomal formulation. Indocyanine green was used as the light-sensitizing compound in the liposomes since it is clinically approved light-sensitive agent. Three different liposomal formulations were prepared: Formulation A: ICG in the aqueous core, liposomes coated Formulation B: ICG in the liposomal Continue reading →Customer case Faculty of Pharmacy at University of Helsinki is specialized in top-level pharmaceutical research. Multidisciplinary research fields include clinical pharmacy, experimental drugs, nanomedicines, and pharmaceutical drug design. Drug delivery unit led by Professor Arto Urtti focuses on design and testing of advanced drug delivery systems especially for ocular indications. Light is studied as an important tool to control the drug delivery to the target tissues. Modulight products: ML6600 (810 nm) + Modulight in vitro illumination kit (MLAKIT) Professor Arto Urtti   Senior Pharmaceutical Researcher Tatu Continue reading →

Ophthalmic laser platform utilizing AI to enhance treatment planning of liposomal drug release

March 7, 2022 by Modulight
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Presented in: SPIE BIOS 2022 Authors: Eero Koivumäki, Laura Vesala, Jukka-Pekka Alanko, Timo Tanila, Petteri Uusimaa, Modulight Corporation (Finland)    Presented in: SPIE BIOS 2022 Authors: Eero Koivumäki, Laura Vesala, Jukka-Pekka Alanko, Timo Tanila, Petteri Uusimaa, Modulight Corporation (Finland)   Delivery of pharmaceuticals to the eye posterior poses a major challenge in ophthalmology. A promising drug delivery platform is indocyanine green (ICG) liposomes, which absorb near-infrared light resulting in a release of pharmaceutical molecules. The Modulight ophthalmic laser platform has been designed for treatments targeting the eye posterior and can also excite the absorption band of the liposomes. The laser connects with Modulight Cloud, enabling Continue reading →

Light-activated drug release using an automated well plate illuminator

March 4, 2022 by Modulight Content
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Presented in: SPIE BIOS 2022 Authors: Laura Vesala, Robert Perttilä, Elias Kokko, Lasse Orsila, Modulight Corporation (Finland), Tampere Univ. Hospital (Finland); Petteri Uusimaa, Modulight Corporation (Finland)    Presented in: SPIE BIOS 2022 Authors: Laura Vesala, Robert Perttilä, Elias Kokko, Lasse Orsila, Modulight Corporation (Finland), Tampere Univ. Hospital (Finland); Petteri Uusimaa, Modulight Corporation (Finland) Efficient site-specific delivery of systemic therapeutic drugs is crucial especially in oncology but has proved to be challenging. Drugs can be encapsulated into liposomes that offer improved therapeutic index and distribution of the drug. The release of the drug can be efficiently achieved by integrating light-sensitive component into liposomes and applying near-infrared light in a time- and site-specific manner. Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – October 2021

November 1, 2021 by Modulight Content
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   Modulight Spotlights: LASER-SHARP RESEARCH – October 2021 This time we wanted to highlight Professor Tebello Nyokong’s team at Rhodes University, since their latest research tackles two big unmet needs in cancer therapy: tumor hypoxia and side effects of the drugs. The team designed multifunctional liposomes that can locally generate oxygen within tumors to alleviate hypoxia, which is a significant contributor to resistance to radio- and chemotherapies. These nanodrugs also hold the potential to reduce problematic side effects of standard cancer therapies as a result of Continue reading →