Tag Archives: PDT

An Infrared Dye–Conjugated Virus-like Particle for the Treatment of Primary Uveal Melanoma

February 1, 2018 by Modulight
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Published in: Molecular Cancer Therapeutics Authors: Rhonda C. Kines, Isabella Varsavsky, Sanghamitra Choudhary, Debaditya Bhattacharya, Sean Spring, Roger McLaughlin, Shin J. Kang, Hans E. Grossniklaus, Demetrios Vavvas, Stephen Monks, John R. MacDougall, Elisabet de los Pinos, and John T. Schiller    Published in: Molecular Cancer Therapeutics Authors: Rhonda C. Kines, Isabella Varsavsky, Sanghamitra Choudhary, Debaditya Bhattacharya, Sean Spring, Roger McLaughlin, Shin J. Kang, Hans E. Grossniklaus, Demetrios Vavvas, Stephen Monks, John R. MacDougall, Elisabet de los Pinos, and John T. Schiller   Laser was used for evaluating tumor-specific targeting and cellular toxicity of their novel IRDye 700DX-conjugated papillomavirus-like particle (AU-011) in vitro using human cancer cell lines. The in vivo experiments were done using other lasers: mice were irradiated with Opto Engine laser and rabbits with Continue reading →

WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice

January 1, 2018 by Modulight
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Published in: Theranostics Authors: Volker Neuschmelting, Kwanghee Kim, Jaber Malekzadeh-Najafabadi, Sylvia Jebiwott, Jaya Prakash, Avigdor Scherz, Jonathan A. Coleman, Moritz F. Kircher, Vasilis Ntziachristos    Published in: Theranostics Authors: Volker Neuschmelting, Kwanghee Kim, Jaber Malekzadeh-Najafabadi, Sylvia Jebiwott, Jaya Prakash, Avigdor Scherz, Jonathan A. Coleman, Moritz F. Kircher, Vasilis Ntziachristos   They used laser to activate Tookad (WST11) in VTP (vascular targeted photodynamic therapy) using renal cancer mouse model to develop multispectral optoacoustic tomography (MSOT) monitoring method for VTP.   Read the article here

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation

November 28, 2016 by Modulight
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Published in: Cardiovascular therapeutics Authors: Manish Jain, Matthieu Zellweger, Georges Wagnières, Hubert van den Bergh, Stéphane Cook, Marie-Noelle Giraud  Published in: Cardiovascular therapeutics Authors: Manish Jain, Matthieu Zellweger, Georges Wagnières, Hubert van den Bergh, Stéphane Cook, Marie-Noelle Giraud   Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction of a coronary artery. During the last decade, scientific evidence demonstrated Continue reading →

EGFR targeted nanobody–photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer

May 10, 2016 by Modulight
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Published in: Journal of Controlled Release Authors: Pieter B.A.A. van Driel, Martin C. Boonstra, Maxime D. Slooter, Raimond Heukers, Marieke A. Stammes, Thomas J.A. Snoeks, Henriette S. de Bruijn, Paul J. van Diest, Alexander L. Vahrmeijer, Paul M.P. van Bergen en Henegouwen, Cornelis J.H. van de Velde, Clemens W.G.M. Löwik, Dominic J. Robinson, Sabrina Oliveira    Published in: Journal of Controlled Release Authors: Pieter B.A.A. van Driel, Martin C. Boonstra, Maxime D. Slooter, Raimond Heukers, Marieke A. Stammes, Thomas J.A. Snoeks, Henriette S. de Bruijn, Paul J. van Diest, Alexander L. Vahrmeijer, Paul M.P. van Bergen en Henegouwen, Cornelis J.H. van de Velde, Clemens W.G.M. Löwik, Dominic J. Robinson, Sabrina Oliveira   They used laser to study EGFR-targeted nanobody-IRDye700DX conjugates for H&N cancer PDT using mouse tumor models.   Read the article here

Workshop: Personalized medicine for better life

March 8, 2016 by Modulight
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Time: Wed 15.6.2016, 8:30–11:00 Place:  Hotel Kämp, Helsinki  Paavo Nurmi cabinet  Pohjoisesplanadi 29, Helsinki, Finland   Confirmed speakers Lecture slideshows   Click here to view our previous workshop at ASLMS-2015. Related products: ML7710 – the tool for professionals »   |   Products for oncology »   |   ML8500 automatic illumination system »   | Illumination kit  »Time: Wed 15.6.2016, 8:30–11:00 Place:  Hotel Kämp, Helsinki  Paavo Nurmi cabinet  Pohjoisesplanadi 29, Helsinki, Finland   Confirmed speakers   Prof. Eero Mervaala: Optogenetics in cardiology and cardiotoxicity Professor, Pharmacology, University of Helsinki Professor Mervaala works in the field of cardiovascular and metabolic pharmacology in the Department of Pharmacology, University of Helsinki, Finland. Prof. Teuvo Tammela: Prostate cancer therapy with laser as part of combinatory treatment Professor in Urology, Tampere University Dr. Teuvo Tammela is a specialist in urology and surgery. He is a meritorious scientist especially Continue reading →

Photodynamic Therapy of Non–Small Cell Lung Cancer. Narrative Review and Future Directions

February 1, 2016 by Modulight
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Published in: Annals of the American Thoracic Society Authors: Gal Shafirstein 1,2, Athar Battoo 3, Kassem Harris 4, Heinz Baumann 5, Sandra O. Gollnick 1,6, Joerg Lindenmann 1,7, and Chukwumere E. Nwogu 3 1Photodynamic Therapy Center 2Department of Cell Stress Biology 3Department of Thoracic Surgery 4Department of Medicine, Interventional Pulmonology 5Department of Molecular and Cellular Biology, and 6Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York; and 7Division of Thoracic and Hyperbaric Surgery, Medical University Graz, Graz, Austria Corresponding Author: Gal Shafirstein    Published in: Annals of the American Thoracic Society Authors: Gal Shafirstein 1,2, Athar Battoo 3, Kassem Harris 4, Heinz Baumann 5, Sandra O. Gollnick 1,6, Joerg Lindenmann 1,7, and Chukwumere E. Nwogu 3 1Photodynamic Therapy Center 2Department of Cell Stress Biology 3Department of Thoracic Surgery 4Department of Medicine, Interventional Pulmonology 5Department of Molecular and Cellular Biology, and 6Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York; and 7Division of Thoracic and Hyperbaric Surgery, Medical University Graz, Graz, Austria Corresponding Author: Gal Shafirstein     The paper describes the history of lung cancer PDT and results from relevant studies. Continue reading →

Rising star in immunotherapy

September 15, 2015 by Seppo Orsila
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San Jose, California & Tampere FINLAND, September 15, 2015 – Modulight, Inc., a leading biomedical laser manufacturer, announces today a rising star in immunotherapy competition. The objective is to help clinicians and biomedical researchers below 35 years old to get their hands on the best possible tools to support photo immunotherapy. All clinicians, residents and biomedical researchers worldwide are eligible to participate the contest by submitting their application via web (research plan, CV and publication list). Final selection of the winner will be done by an independent board of Continue reading →

Protected: Workshop on the best practices in clinical photodynamic therapy Password Protected

August 14, 2015 by Modulight
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There is no excerpt because this is a protected post.Fri 24th April 6 pm, Gaylord Palms Resort, Kissimmee, FL Topics PDT dosimetry – Dr. Gal Shafirstein, Roswell Park Cancer Center, Buffalo, NY [embeddoc url="https://modulight.com/wp-content/uploads/2015/08/ASMLS-2015-PDT-Workshop-Prof.-Shafirstein-Final.pptx" width="280px" height="210px" download="all" viewer="microsoft"] Head & Neck – Dr. Merrill Biel, University of Minnesota Medical School, Minneapolis, MN Cholangiocarsinoma & Esophageal – Dr. Herbert C. Wolfsen, Mayo Clinic, Jacksonville, FL [embeddoc url="https://modulight.com/wp-content/uploads/2015/08/ASLMS_2015_Jones-Wolfsen.pptx" width="280px" height="210px" download="all" viewer="microsoft] Thoracic PDT – Dr. Patrick Ross Jr, The Ohio State University, Columbus, OH Mesothelioma – Dr. Keith Cengel, Perelman School of Medicine, Philadelphia, PA Breast – Dr. Continue reading →

Modulight launches the world’s first multi indication CE and ETL certified medical laser

January 28, 2015 by Anca Guina
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Tampere, January 28, 2015 – Modulight, Inc., a leading biomedical laser manufacturer announced today ML7710 laser platform launch and certification. Unlike other lasers in the industry Modulight ML7710 has been certified and supports a wide range of indications and configurations. Medical CE and ETL marking are valid for all multi-channel (1–8 outputs) laser configurations between 400–2000nm and up to 15W vs. typical application and wavelength specific support. ML7710 supports directly several laser based treatment modalities, like photodynamic therapy (PDT), laser surgery, photo disinfection, and photo coagulation. This saves Continue reading →

Medical laser system ML7710 – Tool for professionals

June 18, 2014 by Modulight
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ML7710Laser Platform for Clinical UseML7710 is the most versatile multichannel, multi-indication and cloud connected medical laser in the world. ML7710 supports all known photosensitizers and user-friendly self-calibration. The treatment flow can be customized for specific needs guaranteeing ultimate patient safety and comfort.Perfect laser for clinical and pre-clinical applications ML7710 is a cloud-connected clinical laser platform, suitable for various medical applications, ranging from photodynamic therapy to fluorescence imaging and photothermal therapy. The system can be equipped with up to eight (8) laser outputs on same or Continue reading →