Author Archives: Modulight Content

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Immune checkpoint inhibition combined with targeted therapy using a novel virus‑like drug conjugate induces complete responses in a murine model of local and distant tumors

March 30, 2023 by Modulight Content
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Published in: Cancer Immunology, Immunotherapy Authors: Ruben V. Huis in ‘t Veld, Sen Ma, Rhonda C. Kines, Anneli Savinainen, Cadmus Rich, Ferry Ossendorp, Martine J. Jager    Published in: Cancer Immunology, Immunotherapy Authors: Ruben V. Huis in ‘t Veld, Sen Ma, Rhonda C. Kines, Anneli Savinainen, Cadmus Rich, Ferry Ossendorp, Martine J. Jager   AU-011 combination with immune checkpoint inhibitors (ICI) was studied in murine models. This has potential to improve treatment efficacy against metastatic tumors by abscopal immune effects. ICI was shown to increase AU-011 efficacy and also result in abscopal effect and induced complete responses in 75% of animals. ML6700 was used as illumination source for PDT. Metastases remain the Continue reading →

Fluorescence-guided, targeted photochemotherapy of peritoneal carcinomatosis

March 17, 2023 by Modulight Content
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Presented in: SPIE BIOS 2023 Authors: Barry J. Liang, Robert Perttilä, Sumiao Pang, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron J. Sorrin, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang    Presented in: SPIE BIOS 2023 Authors: Barry J. Liang, Robert Perttilä, Sumiao Pang, Chen-Hua Ma, Payal Srivastava, Brandon Gaitan, Aaron J. Sorrin, Zoe Ylöniemi, Dana Roque, Tayyaba Hasan, Petteri Uusimaa, Huang-Chiao Huang   Management of peritoneally metastatic cancer is a major clinical challenge. Peritoneal carcinomatosis is observed in 50% of colorectal cancer patients and >75% of ovarian cancer patients at the time of diagnosis. Selected patients based on age, comorbidities, and extent of the metastatic disease, will undergo complete cytoreductive surgery to remove the visible Continue reading →

Novel ophthalmic laser system paired with focal electroretinography for subthreshold laser therapy of DME

March 17, 2023 by Modulight Content
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Presented in: SPIE BIOS 2023 Authors: Jukka-Pekka Alanko, Eero Koivumäki, Laura Vesala, Johannes Kivelä, Zoe Ylöniemi, Petteri Uusimaa, Ossi Kaikkonen, Teemu Turunen, Jaakko Nieminen, Jani Tirronen    Presented in: SPIE BIOS 2023 Authors: Jukka-Pekka Alanko, Eero Koivumäki, Laura Vesala, Johannes Kivelä, Zoe Ylöniemi, Petteri Uusimaa, Ossi Kaikkonen, Teemu Turunen, Jaakko Nieminen, Jani Tirronen   In the field of ophthalmic treatments, subthreshold laser therapy (SLT) has shown promise in addressing retinal diseases like diabetic macular edema (DME) and age-related macular degeneration (AMD). However, the precise control of therapeutic temperatures is challenging due to variations in individual eye characteristics. Modulight and Maculaser have addressed this issue with their innovative ML6710i device. This device utilizes a combination of laser beams to achieve precise thermal Continue reading →

Output beam engineering with 2-step ridge etching

March 17, 2023 by Modulight Content
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Presented in: SPIE OPTO 2023 Authors: Riina Ulkuniemi, Ville Vilokkinen, Petri Melanen, Petteri Uusimaa    Presented in: SPIE OPTO 2023 Authors: Riina Ulkuniemi, Ville Vilokkinen, Petri Melanen, Petteri Uusimaa   Silicon photonics offers platforms to build mass-producible optical circuits. Extremely small optical components are required for this purpose, so fiber coupled systems are an order of magnitude too large. In order to successfully integrate laser source to the circuits, output beam properties have to be controlled and desired for the purpose. When fabricating single-mode ridge waveguide (RWG) laser diodes, ridge width has to be narrow enough for ensuring single-mode operation. Continue reading →

Laser platform and light delivery optimization for bladder cancer treatment with a novel photosensitive drug

March 14, 2023 by Modulight Content
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Presented in: SPIE BIOS 2023 Authors: Zoe Ylöniemi, Elias Kokko, Visa Kaivosoja, Ana Colucci, Eerika Suokas, Jukka-Pekka Alanko, Petteri Uusimaa, Modulight Corp.    Presented in: SPIE BIOS 2023 Authors: Zoe Ylöniemi, Elias Kokko, Visa Kaivosoja, Ana Colucci, Eerika Suokas, Jukka-Pekka Alanko, Petteri Uusimaa, Modulight Corp.   Non-muscle invasive bladder cancer (NMIBC) is a form of cancer with a relatively high 5-year survival rate but also very high recurrence rate. Photodynamic diagnosis is commonly used in standard clinical practice to visualize bladder cancer lesions as part of a TURBT procedure but photodynamic treatments utilizing photosensitive drugs have had limited success in clinical setting partly because of limitations in light Continue reading →

Novel ophthalmic PDT laser platform to target oncology and various other retinal indications

March 14, 2023 by Modulight Content
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Presented in: SPIE BIOS 2023 Authors: Laura Vesala, Eero Koivumäki, Jukka-Pekka Alanko, Timo Tanila, Ivan Baldin, Zoe Ylöniemi, Petteri Uusimaa, Modulight Corp.    Presented in: SPIE BIOS 2023 Authors: Laura Vesala, Eero Koivumäki, Jukka-Pekka Alanko, Timo Tanila, Ivan Baldin, Zoe Ylöniemi, Petteri Uusimaa, Modulight Corp.   Laser systems, in ophthalmic applications, are utilized in the treatment of various ophthalmic diseases such as in ocular oncology and age-related macular degeneration through photochemical mechanism of photodynamic therapy. In addition, these lasers can be used to activate drug delivery systems in the retina to provide targeted drug therapy. PDT is a form of a combination treatment which utilizes light energy to Continue reading →

Optimization of light delivery for non-muscle invasive bladder cancer PDT

March 14, 2023 by Modulight Content
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Presented in: SPIE BIOS 2023 Authors: Elias Kokko, Robert Perttilä, Zoe Ylöniemi, Visa Kaivosoja, Jukka-Pekka Alanko, Petteri Uusimaa, Modulight Corp.    Presented in: SPIE BIOS 2023 Authors: Elias Kokko, Robert Perttilä, Zoe Ylöniemi, Visa Kaivosoja, Jukka-Pekka Alanko, Petteri Uusimaa, Modulight Corp.   Non-muscle invasive bladder cancer (NMIBC) is a form of cancer with a relatively high 5-year survival rate but also very high recurrence rate. Photodynamic diagnosis is commonly used in standard clinical practice to visualize bladder cancer lesions as part of a TURBT procedure but photodynamic treatments utilizing photosensitive drugs have had limited success in clinical setting partly because of limitations in light sources and Continue reading →

Configurable multiwavelength narrow linewidth laser system for quantum applications

March 8, 2023 by Modulight Content
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Presented in: SPIE Quantum West 2023 Authors: Kostiantyn Nechay, Luukas Kuusela, Ossi Mäkinen, Riina Ulkuniemi, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa    Presented in: SPIE Quantum West 2023 Authors: Kostiantyn Nechay, Luukas Kuusela, Ossi Mäkinen, Riina Ulkuniemi, Pekko Sipilä, Kalle Palomäki, Petteri Uusimaa   Single-frequency laser sources serve as a backbone for quantum computing and metrology technologies and applications. Availability of integrated laser systems delivering tailored multiwavelength emission across optical spectrum is a defining factor for further quantum technologies development and commercialization. Modulight demonstrates highly integrated ML6600 laser system for cooling and repumping of 87Rb atoms at D2 line. Such laser system incorporates driving electronics, internal spectroscopy-locked Continue reading →

Optimization and fabrication of 780 nm DFB lasers for quantum systems

March 8, 2023 by Modulight Content
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Presented in: SPIE Quantum West 2023 Authors: Riina Ulkuniemi, Luukas Kuusela, Timo Aho, Petteri Uusimaa    Presented in: SPIE Quantum West 2023 Authors: Riina Ulkuniemi, Luukas Kuusela, Timo Aho, Petteri Uusimaa   Laser diode solutions for quantum systems have highly variable requirements, depending on the technology and purpose of the laser used in the application – for instance, quantum control of particles or molecules and excitation of the quantum systems. Requirements of the laser systems used in the mentioned applications are highly demanding, such as single-mode operation, frequency stability over operation lifetime and narrow spectral linewidth. Narrow spectral linewidth can be achieved with Continue reading →

High aspect ratio DBR gratings for narrow linewidth red lasers

March 8, 2023 by Modulight Content
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Presented in: SPIE Quantum West 2023 Authors: Luukas Kuusela, Riina Ulkuniemi, Timo Aho, Petteri Uusimaa    Presented in: SPIE Quantum West 2023 Authors: Luukas Kuusela, Riina Ulkuniemi, Timo Aho, Petteri Uusimaa   In interferometry, spectroscopy, and holography, HeNe lasers or semiconductor lasers with external wavelength stabilization have been widely used to achieve the required narrow linewidth at 633 nm. Semiconductor lasers utilizing wavelength selective grating fabricated on semiconductor chip enable the miniaturization of laser systems while also providing numerous advantages such as low energy consumption, reliability and tunability by temperature and injection current. Moreover, DBR gratings reduce the complexity of the laser system compared Continue reading →