Tag Archives: RGB

Fluorescence imaging & endoscopy for tumor visualization and diagnostics

Several fluorescent agents have been approved for fluorescence based diagnosis & intraoperative imaging: Dye generic name Countries Excitation Detection Indications Indocyanine Green (ICG) Worldwide 800 nm Near-infrared (820 nm) Multiple uses: lymphatic mapping, tissue perfusion, visualization of biliary ducts and blood veins, retinal angiography Fluorescein Worldwide 490 nm Green fluorescence (525 nm) Fluorescein angiography or angioscopy (ophthalmology) Methylene Blue Worldwide 665 nm 688 nm Endoscopic polypectomy, chromoendoscopy, lymphatic drainage 5-ALA Hydrochloride (converted to Pp-IX) Worldwide 400 – 410 nm Red fluorescence (620 – 710 nm) Continue reading →Introduction to fluorescence imaging Fluorescence is a phenomenon where substance that has absorbed certain wavelength of light emits it back at another wavelength. These substances are called fluorophores or fluorescent dyes. The emitted light has a longer wavelength than the absorbed one since some energy of the photon is lost in the process. The difference in wavelengths between absorbed and emitted light, called Stokes shift, allows very low background for fluorescence detection by separating it from the excitation light. The process of fluorescence generation is Continue reading →

Configurable multi-wavelength laser light engine for endoscopic fluorescence imaging

Presented in: SPIE BIOS 2022 Authors: Zoe Ylöniemi, Visa Kaivosoja, Lasse Orsila, Tero Vierimaa, Petteri Uusimaa, Modulight Corporation (Finland)    Presented in: SPIE BIOS 2022 Authors: Zoe Ylöniemi, Visa Kaivosoja, Lasse Orsila, Tero Vierimaa, Petteri Uusimaa, Modulight Corporation (Finland)   Using different fluorescent dyes for clinical applications need endoscopic illumination sources with multiple wavelengths. Fluorescent imaging with simultaneous white light overlay image benefit from laser light sources for fluorescence excitation and white light illumination to allow for easy spectral filtering on imaging side. Imaging of complementary fluorescent dyes adds requirements for the light source. Modulight ML7710 oncology laser platform was developed to fulfill the requirements Continue reading →

Multimodal imaging microscope for tissue engineering applications

  Motivation for the study Tissue engineering is an evolving field of medicine that aims to grow new viable tissue for repairing or regenerating damaged tissues in the body. These tissue constructs are typically made by placing cells in support matrices that have proper growth-inducing factors. However, visualizing the development and composition of these tissue constructs is challenging with currently available optical imaging methods: they are either not capable of producing 3D images at sufficient depth or lack the bright-field imaging functionality. To answer this Continue reading →Customer case Research by: Computational biophysics and imaging research group at Tampere University. Research topics include development of bioimaging, analysis and biophysics based in-silico tools for new personalized treatments and diagnostics. Modulight products: ML6600 (488, 561, and 635 nm) Laser use: Light source for in-house built multimodal 3D imaging microscope used for imaging tissue engineering processes and products.   Professor Jari Hyttinen     Link to the study:   Toni Montonen, Doctoral Researcher     Motivation for the study Tissue engineering is an evolving field of Continue reading →

Modulight broadens their OEM laser system family to single-mode and multi-wavelength laser modules

Tampere, Finland – Jan 30th 2014 – Modulight, Inc., an ISO13485 certified laser manufacturer based in Tampere, Finland and San Jose CA, announced today two complementary additions to their OEM laser system platform. Whereas ML6500, released in 2013, introduced the smallest form factor and the widest wavelength spread high-power multimode laser modules in the industry, the new release complements this with the ML6400 single-mode laser systems and ML6600 multi-wavelength laser systems. The smaller sibling ML6400 footprints 2″x2″ and the 6″x6″ big brother ML6600 houses up Continue reading →

Modulight launches 1W RGB LimeLight laser modules with the smallest form factor in the industry

Tampere, Finland Jan 28th 2013 – Modulight, Inc., an ISO13485:2003 certified laser manufacturer based in Tampere, Finland and San Jose, CA,announced today the release of their renewed LimeLight laser systems offering the smallest form factor RGB laser solution in the industry. The systems produce 1W output power at 635nm, 532nm and 465nm from only 3″x3″ footprint. While the well-known Modulight LimeLight platform has been cut to half in volume, it houses even more functionalities and offers unbeaten spread of wavelength from visible 465nm to NIR Continue reading →