Tag Archives: Photoimmunotherapy

Modulight Spotlights: LASER-SHARP RESEARCH – September 2021

October 1, 2021 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – September 2021 Laser-Sharp Research nomination goes to this month for Professor Kobayashi’s team and Dr. Noriko Sato’s team at National Cancer Institute, National Institute of Health, USA. Their research published in a prestigious Cancer Research journal showed that photoimmunotherapy can not only target tumor cells, but can also be harnessed to target body’s own tumor-promoting immune cells within the tumor. These special cells called intratumoral Tregs were selectively killed by photoimmunotherapy upon illumination with ML7710 laser, which led to activation Continue reading →

Combining photoimmunotherapy with immune checkpoint inhibition

July 14, 2021 by Modulight Content
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Motivation for the study The motivation was to study if photoimmunotherapy could enhance anti-tumor immunity when combined with immune checkpoint inhibition. CD44-targeted photoimmunotherapy was applied against poorly immunogenic, “cold” tumor and antitumor effect was studied alone and in combination with anti-PD-1 immune checkpoint inhibition. Sensitization of this “cold” tumor to immune checkpoint inhibition after photoimmunotherapy would mean that the tumor has been converted into highly immunogenic, “hot” tumor infiltrated with killer T cells mainly responsible for eradicating the tumor. The formation of immunological antitumor memory Continue reading →Customer case The Laboratory of Molecular Theranostics at National Cancer Institute (NCI) is a major research section of the Molecular Imaging Program at National Cancer Institute (NCI) and is led by Dr. Hisataka Kobayashi who is the father of photoimmunotherapy. The ground-breaking research includes the development of imaging and theranostic probes with a particular emphasis on optical probes, which can aid in cancer detection during cancer resection or endoscopy. Dr. Hisataka Kobayashi M.D., PhD Dr. Peter L. Choyke M.D., PhD   Modulight products: ML7710 (multiple channels Continue reading →

ML7710 for photoimmunotherapy against regulatory T cells in tumors

June 14, 2021 by Modulight Content
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    Results Tumor growth was significantly suppressed by photoimmunotherapy, compared to control or IgG without light activation. Tumor growth suppression, as well as overall survival after photoimmunotherapy, were significantly better with F(ab´)2 fragments than with full IgG. This efficacy improvement might be related to killer T cells, which were detected in much higher numbers after photoimmunotherapy with F(ab´)2 fragments and are key cells for the generation of efficient systemic antitumor immunity.       Related Modulight products and Services   Related Publications The Effect Continue reading →Customer case The Laboratory of Molecular Theranostics is a major research section of the Molecular Imaging Program at National Cancer Institute (NCI) and is led by Dr. Hisataka Kobayashi. The groundbreaking research includes the development of imaging and theranostic probes, which can aid in cancer detection and treatment. Dr. Kobayashi has invented near-infrared photoimmunotherapy (NIR-PIT) with IRDye700DX, which is currently in FDA-designated fast-track Phase 3 trials for inoperable Head & Neck cancer. Dr. Hisataka Kobayashi M.D., PhD   Dr. Peter L. Choyke M.D., PhD   Continue reading →

Rapid Depletion of Intratumoral Regulatory T cells Induces Synchronized CD8 T and NK Cell Activation and IFN-γ-dependent Tumor Vessel Regression

June 1, 2021 by Modulight
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Published in: Cancer Research Authors: Yutaka Kurebayashi, Colleen P. Olkowski, Kelly C. Lane, Olga V. Vasalatiy, Biying C. Xu, Ryuhei Okada, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi, Noriko Sato    Published in: Cancer Research Authors: Yutaka Kurebayashi, Colleen P. Olkowski, Kelly C. Lane, Olga V. Vasalatiy, Biying C. Xu, Ryuhei Okada, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi, Noriko Sato   Tumor-infiltrating regulatory T cells (Tregs) were selectively depleted using anti-CD25 antibody fragment mediated NIR-PIT with ML7710 (50 J/cm2) in tumor-bearing mice. This induced transient IFN-γ expression in CD8 T and NK cells, which lead to efficient and rapid tumor vessel regression, intratumoral ischemia, and tumor necrosis/apoptosis and growth suppression. These results indicate the pivotal Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – May 2021

June 1, 2021 by Modulight Content
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Modulight Spotlights: LASER-SHARP RESEARCH – May 2021 The renowned pioneer in photoimmunotherapy (PIT), Professor Hisataka Kobayashi, has published an outstanding article with his team at National Cancer Institute / NIH. The article is about improving the antitumor efficacy of near-infrared photoimmunotherapy (NIR-PIT) by simultaneous targeting of cancer cells and regulatory T cells in the tumor microenvironment. Read original publication   Modulight is very happy to be supporting this research. We would like to deliver our warmest congratulations to the research team!   #LaserSharpResearch  #ModulightInScience   Continue reading →