Tag Archives: illumination

Modulight Spotlights: LASER-SHARP RESEARCH – November 2024

November 19, 2024 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – November 2024 The lungs are common site of cancer metastasis, with isolated pulmonary metastases most often affecting patients with colorectal cancer and sarcomas. Surgical metastasectomy is the standard treatment, however, only 1 in 10 patients qualify for surgical resection thus the management remains a significant clinical challenge. To tackle this challenge, K. Ramadan et al. studied photodynamic therapy in an isolated lung perfusion model where the blood is replaced with acellular perfusate, allowing greater light penetration. The feasibility and safety Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – April 2024

April 10, 2024 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – April 2024 First-in-human, phase 1 clinical trial results with ML7710 have been published in a renowned journal Radiology by Timothy Baran and team at University of Rochester Medical Center. The trial investigated treatment of deep tissue abscesses using photodynamic therapy with methylene blue and ML7710 laser. Abscesses are painful collection of pus, usually caused by a bacterial infection. Standard treatment is abscess drainage and antibiotics, however treatment responses vary widely and are linked to prolonged hospital stay, costs, and patient discomfort, as well as increasing concerns for antibiotic-resistance. The trial in 18 Continue reading →

Photobiomodulation for pain treatment using ML6600

March 15, 2024 by Modulight Content
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Background Photobiomodulation with low-level laser or light therapy is an effective treatment for pain. It has various effects, such as analgesic (pain-relieving) effects, anti-inflammatory effects, tissue regeneration promoting effects, and wound healing effects. Photobiomodulation can be used to relief both acute and chronic pain and has the advantage of being noninvasive and safe. Earlier studies have shown that photobiomodulation affects the activity of pain-transmitting nerves, even though the mechanisms are not fully understood. Because lasers are scattered and absorbed by biological tissues, the laser intensity Continue reading →Customer case University of Toyama is a Japanese national university located in Toyama City and Takaoka City and established in 1949. It is comprised of 3 former national universities Toyama University, Toyama Medical and Pharmaceutical University, and Takaoka National College. Naoya Ishibashi Daisuke Uta Modulight products: ML6600 Laser use: Studying pain treatment with photobiomodulation. Links to articles:     Background Photobiomodulation with low-level laser or light therapy is an effective treatment for pain. It has various effects, such as analgesic (pain-relieving) effects, anti-inflammatory effects, tissue regeneration Continue reading →

Hyperspectral imaging for flow cytometry

January 28, 2024 by Modulight Content
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Published in: SPIE BIOS 2024 Authors: Anna Filipchuk, Robert Perttilä, Ana Colucci, Petteri Uusimaa  Published in: SPIE BIOS 2024 Authors: Anna Filipchuk, Robert Perttilä, Ana Colucci, Petteri Uusimaa Flow cytometry is a widely used analysis technique in biomedical sciences. It has found extensive utilization in both clinical diagnostics and cutting-edge biological research. As the method has been gaining greater recognition, its underlying technologies have undergone rapid development to further expand its range of applications. A notable trend is the introduction of imaging modalities to flow cytometry to expand the information content of the analyzed sample.   Read the article Continue reading →

Laser illumination platform with real-time spectral monitoring and treatment

March 7, 2022 by Modulight Content
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Presented in: SPIE BIOS 2022 Authors: Visa Kaivosoja, Robert Perttilä, Elias Kokko, Timo Tanila, Zoe Ylöniemi, Petteri Uusimaa, Modulight Corporation (Finland)    Presented in: SPIE BIOS 2022 Authors: Visa Kaivosoja, Robert Perttilä, Elias Kokko, Timo Tanila, Zoe Ylöniemi, Petteri Uusimaa, Modulight Corporation (Finland) Personalized medicine is one of the main directions in current cancer care. To support this trend, Modulight has designed a laser illumination platform with real-time spectral monitoring to adjust treatments based on each patient’s optical properties of the tissue, providing more personalization to light-based treatments. The laser has been designed to illuminate and retrieve spectral data from the tumor tissue simultaneously from up to Continue reading →

Long-range all-solid-state flash LiDAR sensor for autonomous driving

March 5, 2021 by Modulight Content
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Published in: SPIE LASE 2021 Authors: Juha Lemmetti, Niklas Sorri, Ilkka Kallioniemi, Petri Melanen, Petteri Uusimaa  Published in: SPIE LASE 2021 Authors: Juha Lemmetti, Niklas Sorri, Ilkka Kallioniemi, Petri Melanen, Petteri Uusimaa LiDAR sensors have gathered lot of interest in the field of autonomous driving. Still, the offering of mass-produced, small form-factor all-solid-state LiDAR sensors remain scarce. Furthermore, most of the sensor applications are currently designed for short-range (<50 feet) and medium-range (50-300 feet) applications. There’s a requirement for an efficient solution for long range LiDAR sensor that can be used to monitor the road in front of the vehicle. It must Continue reading →

Configurable cloud based medical laser platform with real-time treatment monitoring

March 5, 2021 by Modulight Content
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Presented in: SPIE BIOS 2021 Authors: Visa Kaivosoja, Zoe Ylöniemi, Juha Lemmetti, Timo Tanila, Lasse Orsila, Petteri Uusimaa, Modulight, Inc. (Finland)    Presented in: SPIE BIOS 2021 Authors: Visa Kaivosoja, Zoe Ylöniemi, Juha Lemmetti, Timo Tanila, Lasse Orsila, Petteri Uusimaa, Modulight, Inc. (Finland) Traditionally one of the biggest challenges with light-based treatment modalities such as photodynamic therapy or different tumor ablation techniques is to determine how much light should be applied to the tissue and how that will be distributed to activate a bio-photonic process or a drug. Different tools have been developed to model light distribution in tissue, but this has not solved the problem of Continue reading →

High-efficiency vertically-emitting chipsets for 3D and proximity sensing

March 5, 2021 by Modulight Content
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Published in: SPIE LASE 2021 Authors: K. Nechay, R. Ulkuniemi, A. Filipchuk, T. Hartikainen, V. Kaivosoja, R. Hietikko, J. Nikkinen, J. Sillanpaa, P. Melanen, V. Vilokkinen, S. Talmila, P. Uusimaa  Published in: SPIE LASE 2021 Authors: K. Nechay, R. Ulkuniemi, A. Filipchuk, T. Hartikainen, V. Kaivosoja, R. Hietikko, J. Nikkinen, J. Sillanpaa, P. Melanen, V. Vilokkinen, S. Talmila, P. Uusimaa Vertical-cavity surface-emitting lasers (VCSELs) have just recently started generating a lot of interest as the illumination source in the multitude of commercial applications. VCSELs capability to provide narrow spectrum emission with low temperature sensitivity and high beam quality, coupled with the possibility of nanosecond pulses generation, makes VCSELs an excellent laser platform for the outdoors, high-precision Continue reading →

Configurable automated well plate illuminator for in vitro research in drug discovery and optogenetics

March 5, 2021 by Modulight Content
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Presented in: SPIE BIOS 2021 Authors: Elias Kokko, Robert Perttilä, Lasse Orsila, Zoe Ylöniemi, Johannes Kivelä, Petteri Uusimaa    Presented in: SPIE BIOS 2021 Authors: Elias Kokko, Robert Perttilä, Lasse Orsila, Zoe Ylöniemi, Johannes Kivelä, Petteri Uusimaa There is a demand for a robust and flexible illumination and screening instrument for preclinical light-sensitive drug development and optogenetic research. While there is a great selection of different types of commercial plate readers available on the market, these instruments do not provide enough versatility for high-throughput illumination experiments. In addition, plate readers typically utilize xenon flash lamps or LEDs for sample analysis, which have wider spectral output and lower excitation powers Continue reading →

Modulight releases a biomedical illumination system

February 16, 2016 by Seppo Orsila
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San Jose, California & Tampere FINLAND, February 16, 2016 – Modulight, Inc., a leading biomedical laser manufacturer, announces today a biomedical illumination system ML8500. ML8500 – biomedical illumination system works seamlessly with Modulight’s ML7710 medical laser or optional internal ML6xxx series lasers. Operating the illumination system is very easy with an intuitive touch-screen interface and a programming through simple Excel® spreadsheet. ML8500 is a great tool for sequential illumination of multi-well sample plates and optional fluoresence imaging/measurement. Fully automatic system takes care of the rest. The product will also offer a Continue reading →