Tag Archives: University of Maryland

Self-Assembled Verteporfin Nanoparticles for Photodynamic and Light-Independent Therapy in Glioblastoma

September 28, 2024 by Modulight Content
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Published in: Advanced NanoBioMed Research Authors: John A. Quinlan, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Robert W. Robey, Michael M. Gottesman, Huang-Chiao Huang  Published in: Advanced NanoBioMed Research Authors: John A. Quinlan, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Robert W. Robey, Michael M. Gottesman, Huang-Chiao Huang A nanosuspension of verteporfin, termed NanoVP, that requires no carriers is developed, permitting delivery of VP alone in an aqueous solution. NanoVP is produced by solvent–antisolvent precipitation, with dimethyl sulfoxide as the preferable solvent. The paper describes the characterization of NanoVP, including bioavailability and anticancer capacity in glioblastoma with ML6600 laser irradiation, as well as potontial of NanoVP for light-independent therapy.   Read Continue reading →

Screening of photosensitizers-ATP binding cassette (ABC) transporter interactions in vitro

September 20, 2024 by Modulight Content
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Published in: Cancer Drug Resistance Authors: Shruti Vig1, Payal Srivastava1,#, Idrisa Rahman1,2,#, Renee Jaranson1, Anika Dasgupta1, Robert Perttilä3, Petteri Uusimaa3, Huang-Chiao Huang1  Published in: Cancer Drug Resistance Authors: Shruti Vig1, Payal Srivastava1,#, Idrisa Rahman1,2,#, Renee Jaranson1, Anika Dasgupta1, Robert Perttilä3, Petteri Uusimaa3, Huang-Chiao Huang1 University of Maryland and Modulight have published together a new research study about the mechanisms of cancer drug resistance. Drug resistance is a leading cause of treatment failure and often has dramatic consequences for survival of cancer patients. Cancer cells have developed various ways to protect themselves from drugs. When several clinically used photoactive drugs were studied, it was shown that some of them were being actively pumped out by cancer cells, thus likely limiting the full therapeutic potential of these Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – March 2024

March 7, 2024 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – March 2024 Glioblastoma is the most aggressive type of brain tumor. It is hard to treat because of its invasion into functioning brain tissues, limited drug delivery due to blood-brain-barrier, and evolved treatment resistance. To address these challenges, a light-activated nanoformulation, called nanoVP, was developed for glioblastoma in a new study co-led by John Quinlan and Collin Inglut in Dr. Huang’s team at the University of Maryland. Published in a prestigious journal Advanced Science, this novel therapy resulted in an improved tumor control and survival Continue reading →

Light penetration depth in brain with different photosensitizers

October 28, 2021 by Modulight Content
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  Motivation for the study Glioblastoma is the most aggressive and lethal brain cancer with an average prognosis of 15 months. Fluorescence-guided surgery (FGS) for glioblastoma was FDA-approved in 2017, while photodynamic therapy (PDT) remains an active area of clinical investigation with very promising results so far. The aim of PDT is to eradicate the invasive cancer cells within 2 cm of the resected area where the glioblastoma most often recurs. However, a significant hurdle of this therapy modality is the limited light penetration depth Continue reading →Customer case Research by: University of Maryland, Optical Therapeutics & Nanotechnology Laboratory led by Prof. Huang. Research focuses on precision cancer nanomedicine, drug delivery strategies, overcoming cancer resistance, mechanism-based combination therapies, site-directed photochemistry and fluorescence diagnostics. Modulight has started a joint R&D program with Dr. Huang lab to study novel EGFR-targeted combination therapy/diagnostic agent PIC-Nal-IRI developed by Huang lab. Modulight products: ML6600 laser system (635 nm and 689 nm). Professor Huang-Chiao Huang Laser use: Targeted photodynamic therapy/photoimmunotherapy with benzoporphyrin derivative (BPD) & 5-aminolevulinic acid (5-ALA) photosensitizers. Continue reading →