Tag: University of Maryland

Modulight Spotlights: LASER-SHARP RESEARCH – November 2025

Laser-sharp Research / cancer, chemotherapy, drug delivery, glioblastoma, in vitro, laser-sharp research, ML8500, multidrug resistance, photoactivated chemotherapy, Photoimmunotherapy, preclinical, therapy resistance, tumor, University of Maryland, verteporfin / November 19, 2025

Modulight Spotlights: LASER-SHARP RESEARCH – November 2025 We are delighted to highlight new exciting study by Rahman et al. from Dr. Huang-Chiao Huang’s lab at University of Maryland. Multidrug resistance remains a significant barrier to successful chemotherapy outcomes for cancer patients, often caused by active pumping of chemotherapeutics outside of cancer cells. Hence, the team [...]

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Fn14-Targeted Gold Nanorods for Augmenting Laser Thermal Therapy for High-Grade Gliomas

Scientific papers / 690 nm, glioblastoma, glioma, in vitro, interstitial, ML6600, photothermal therapy, red laser, University of Maryland / July 8, 2025

Published in: Langmuir Authors: Sumiao Pang, Rebecca J. Johnson, Nikhil Pandey, Anshika Kapur, Pavlos Anastasiadis, Pranjali Kanvinde, Emylee McFarland, Jeffrey A. Winkles, Graeme F. Woodworth, Anthony J. Kim, Huang Chiao Huang

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Modulight Spotlights: LASER-SHARP RESEARCH – June 2025

Laser-sharp Research / Cancer therapy, fluorescence, in vitro, in vivo, laser-sharp research, liver cancer, ML7710, pancreas, pancreatic cancer, theranostics, University of Maryland / June 3, 2025

Chen-Hua Ma et al. Optical Therapeutics & Nanotechnology Laboratory at University of Maryland combined photoimmunotherapy with ethanol ablation to achieve improved drug retention and light penetration, especially important for treating pigmented organs like liver and pancreas. Modulight’s ML7710 laser was used for both therapeutic activation of the nanoconstruct, as well as for theranostic monitoring of the process.

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Synergizing photodynamic therapy and ethanol ablation: Light-activatable sustained-exposure ethanol injection technology for enhanced tumor ablation

Scientific papers / Cancer therapy, fluorescence, in vitro, in vivo, liver cancer, ML7710, pancreas, pancreatic cancer, theranostics, University of Maryland / May 15, 2025

Published in: Bioengineering & Translational Medicine Authors: Chen-Hua Ma, Jeffrey Yang, John A. Quinlan, Kathryn McNaughton, Michele L. Kaluzienski, Tessa Hauser, Matthew F. Starost, Jenna L. Mueller, Huang-Chiao Huang

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Self-Assembled Verteporfin Nanoparticles for Photodynamic and Light-Independent Therapy in Glioblastoma

Scientific papers / 690 nm, glioblastoma, in vitro, in vivo, ML6600, PDT, University of Maryland, verteporfin / September 28, 2024

Published in: Advanced NanoBioMed Research Authors: John A. Quinlan, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Robert W. Robey, Michael M. Gottesman, Huang-Chiao Huang

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Screening of photosensitizers-ATP binding cassette (ABC) transporter interactions in vitro

Scientific papers / cancer, cancer treatment, drug resistance, in vitro, Modulight in science, pumps, therapy resistance, University of Maryland / September 20, 2024

Published in: Cancer Drug Resistance Authors: Shruti Vig1, Payal Srivastava1,#, Idrisa Rahman1,2,#, Renee Jaranson1, Anika Dasgupta1, Robert Perttilä3, Petteri Uusimaa3, Huang-Chiao Huang1

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Modulight Spotlights: LASER-SHARP RESEARCH – March 2024

Laser-sharp Research / blood-brain-barrier, brain cancer, drug delivery, glioblastoma, laser-sharp research, ML6600, MLACAL, nanoparticle, University of Maryland / March 7, 2024

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Light penetration depth in brain with different photosensitizers

Application Note / 5-ALA, 635 nm, 689 nm, BPD, brain cancer, glioblastoma, ML6600, PDT, Photoimmunotherapy, PIT, PPIX, University of Maryland, verteporfin / October 28, 2021

Motivation for the study Glioblastoma is the most aggressive and lethal brain cancer with an average prognosis of 15 months. Fluorescence-guided surgery (FGS) for glioblastoma was FDA-approved in 2017, while photodynamic therapy (PDT) remains an active area of clinical investigation with very promising results so far. The aim of PDT is to eradicate the

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