University of Helsinki

Photothermal and photo-oxidation mediated release of lipophilic paclitaxel from liposomes: from formulation to in vitro efficacy and molecular dynamics simulations

Published in: International Journal of Pharmaceutics Authors: Eija Ilvesroiha, Suvi Heinonen, Riikka Rimmistö, Timo Oksanen, Nikita Durandin, Alex Bunker, Artturi Koivuniemi, Tatu Lajunen, Timo Laaksonen    

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Harnessing liposomal nanocellulose hydrogel for NIR-light driven on-demand drug delivery

Published in: Carbohydrate Polymer Technologies and Applications Authors: Puja Gangurde, Zahra Gounani, Jacopo Zini, Roberta Teixeira Polez, Monika Osterberg, Patrick Lauren, Tatu Lajunen, Timo Laaksonen    

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Modulight Spotlights: LASER-SHARP RESEARCH – October 2024

Modulight Spotlights: LASER-SHARP RESEARCH – October 2024 This month, we are highlighting new findings published in RSC Materials Advances by Olga Lem, Roosa Kekki and researchers at Pharmaceutical Nanotechnology research group and Tampere University. The study provides key insights into the role of lipid oxidation in cargo release from light-activated liposomes. These spherical lipid vesicles can

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Development of thermosensitive liposomes with the help of ML8500

Development of thermosensitive liposomes with the help of ML8500

Background The proper delivery and release of therapeutic drugs to a specific site or cell type is one of the main challenges in the treatment of diseases. Liposomes, which are vesicles composed of lipids, serve as carriers for drug delivery thanks to their long circulation time. This results to reduced toxicity in healthy tissues and

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Development of Robust Cationic Light-Activated Thermosensitive Liposomes: Choosing the Right Lipids

Published in: Molecular Pharmaceutics Authors: Puja Gangurde, Mohammad Mahmoudzadeh, Zahra Gounani, Artturi Koivuniemi, Patrick Laurén, Tatu Lajunen, Timo Laaksonen    

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Light-induced drug delivery with indocyanine green liposomes

Light-induced drug delivery with indocyanine green liposomes

Introduction to light-controlled drug delivery systems Study description It is important that light-triggered liposomes efficiently release their contents, while the liposome stability should be maintained in the absence of laser light. The aim of this study is to determine how liposomal stability and drug release are affected by liposomal formulation. Indocyanine green was used as the light-sensitizing compound

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