Tag Archives: tumor

Automated drug detection and dynamic measurement prioritization with medical laser platform

Published in: SPIE BIOS 2024 Authors: Henri Auvinen, Lassi Luokkanen, Zoe Ylöniemi, Natalia Leinonen, Ana Colucci, Petteri Uusimaa  Published in: SPIE BIOS 2024 Authors: Henri Auvinen, Lassi Luokkanen, Zoe Ylöniemi, Natalia Leinonen, Ana Colucci, Petteri Uusimaa Monitoring treatment through spectral data enables adjusting treatment in real-time for each patient separately, in line with the trend for personalized medicine. Modulight ML7710 laser can simultaneously measure spectral data from up to 8 different locations in tumor tissue. The laser with this optical monitoring feature is currently being tested in glioblastoma trials in Germany where patients receive photoimmunotherapy and treatment is tailored through spectral monitoring of Continue reading →

Treg-Dominant Tumor Microenvironment Is Responsible for Hyperprogressive Disease after PD-1 Blockade Therapy

Published in: Cancer Immunology Research Authors: Hiroaki Wakiyama, Takuya Kato, Aki Furusawa, Ryuhei Okada, Fuyuki Inagaki, Hideyuki Furumoto, Hiroshi Fukushima, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi    Published in: Cancer Immunology Research Authors: Hiroaki Wakiyama, Takuya Kato, Aki Furusawa, Ryuhei Okada, Fuyuki Inagaki, Hideyuki Furumoto, Hiroshi Fukushima, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi   Cytotoxic T cells were partially depleted by NIR-PIT (using ML7710 for light activation) in mouse tumor models. PD-1 blockage led to rapid tumor progression compared with controls, indicating that rapid tumor progression, called hyperprogressive disease, after PD-1 blockage therapy can be attributed to imbalance between T cell populations.   Read the article here

Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW

Published in: Frontiers in Oncology Authors: Chanda Bhandari, John Fakhry, Menitte Eroy, Jane Junghwa Song, Kimberley Samkoe, Tayyaba Hasan, Kenneth Hoyt, Girgis Obaid    Published in: Frontiers in Oncology Authors: Chanda Bhandari, John Fakhry, Menitte Eroy, Jane Junghwa Song, Kimberley Samkoe, Tayyaba Hasan, Kenneth Hoyt, Girgis Obaid   The study showed that photodynamic priming (subtherapeutic doses of light using ML6500) of tumor microenvironment with nanoliposomal BPD is highly beneficial for delivery of antibodies (Cet-IR800) to H&N tumor in mice. Priming significantly improved the tumor accumulation of Cet-IR800 and diagnostic accuracy of tumor detection, as monitored with fluroescence imaging.   Read the article here

Cyanine Phototruncation Enables Spatiotemporal Cell Labeling

Published in: Journal of the American Chemical Society Authors: Hiroshi Fukushima, Siddharth S. Matikonda, Syed Muhammad Usama, Aki Furusawa, Takuya Kato, Lenka Štacková, Petr Klán, Hisataka Kobayashi, Martin J. Schnermann  Published in: Journal of the American Chemical Society Authors: Hiroshi Fukushima, Siddharth S. Matikonda, Syed Muhammad Usama, Aki Furusawa, Takuya Kato, Lenka Štacková, Petr Klán, Hisataka Kobayashi, Martin J. Schnermann In this study, phototruncation-assisted cell tracking (PACT) was developed to enable spatiotemporal tracking of immune cell populations in vivo. It is based on cyanine photoconversion reaction that leads to 2-carbon truncation and blue shift in the emission wavelength when irradiated with NIR light. ML6600 (780 nm) was used to induce photoconversion both in vitro and Continue reading →

Antitumor Effect and Induced Immune Response Following Exposure of Hexaminolevulinate and Blue Light in Combination with Checkpoint Inhibitor in an Orthotopic Model of Rat Bladder Cancer

Published in: Biomedicines Authors: Laureline Lamy, Jacques Thomas, Agnès Leroux, Jean-François Bisson, Kari Myren, Aslak Godal, Gry Stensrud, Lina Bezdetnaya    Published in: Biomedicines Authors: Laureline Lamy, Jacques Thomas, Agnès Leroux, Jean-François Bisson, Kari Myren, Aslak Godal, Gry Stensrud, Lina Bezdetnaya   Blue light cystoscopy/Photodynamic diagnosis (PDD) was shown in rat models of bladder cancer to not only help in visualization and better removal of tumors, but also lead to anti-tumor effects and stimulation of immune system. ML6500 was used as blue light source for PDD.   Read the article here

Optimized light delivery in pancreatic cancer

Motivation for the study Efficient light delivery to the whole tumor is one of the main aspects of phototherapy. The efficacy of phototherapy has been demonstrated for several cancers via superficial illumination. Interstitial illumination could enhance light delivery deeper inside the tumor and potentially result in more effective tumor eradication. Hence, the aim of this study is to compare if the therapeutic efficacy of phototherapy is dependent on the light delivery strategies.   Results Phototherapy (PT) with both superficial and interstitial illumination methods efficiently eradicated Continue reading →Customer case University of California at Irvine (UCI), founded in 1965, is a Top 10 public university in USA. It is recognized for cutting-edge and innovative scientific research. Modulight products: ML7710 (689 nm) Laser use: Targeted phototherapy studies with photo-immunoconjugates Link to the study: Nzola De Magalhães, Adjunct Assistant Professor   Motivation for the study Efficient light delivery to the whole tumor is one of the main aspects of phototherapy. The efficacy of phototherapy has been demonstrated for several cancers via superficial illumination. Interstitial illumination could Continue reading →

Rapid Depletion of Intratumoral Regulatory T cells Induces Synchronized CD8 T and NK Cell Activation and IFN-γ-dependent Tumor Vessel Regression

Published in: Cancer Research Authors: Yutaka Kurebayashi, Colleen P. Olkowski, Kelly C. Lane, Olga V. Vasalatiy, Biying C. Xu, Ryuhei Okada, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi, Noriko Sato    Published in: Cancer Research Authors: Yutaka Kurebayashi, Colleen P. Olkowski, Kelly C. Lane, Olga V. Vasalatiy, Biying C. Xu, Ryuhei Okada, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi, Noriko Sato   Tumor-infiltrating regulatory T cells (Tregs) were selectively depleted using anti-CD25 antibody fragment mediated NIR-PIT with ML7710 (50 J/cm2) in tumor-bearing mice. This induced transient IFN-γ expression in CD8 T and NK cells, which lead to efficient and rapid tumor vessel regression, intratumoral ischemia, and tumor necrosis/apoptosis and growth suppression. These results indicate the pivotal Continue reading →

Virus-like particle-drug conjugates induce protective, long-lasting adaptive anti-tumor immunity in the absence of specifically targeted tumor antigens

Published in: Cancer Immunology Research Authors: Rhonda C Kines, Cynthia D Thompson, Sean Spring, Zhenyu Li, Elisabet de los Pinos, Stephen Monks, John T Schiller       Related application note: Vision-sparing targeted phototherapy for uveal melanoma  Published in: Cancer Immunology Research Authors: Rhonda C Kines, Cynthia D Thompson, Sean Spring, Zhenyu Li, Elisabet de los Pinos, Stephen Monks, John T Schiller   This study examined the ability of a papillomavirus-like particle drug-conjugate (AU-011) to eradicate subcutaneous tumors after intravenous injection and to subsequently elicit long-term anti-tumor immunity in the TC-1 syngeneic murine tumor model. Also the combination of AU-011 with immune checkpoint inhibitor antibodies (anti-CTLA-4 or anti-PD-1) was studied and improved therapeutic efficacy. Modulight laser + MLAKIT was used only for Continue reading →

An Infrared Dye–Conjugated Virus-like Particle for the Treatment of Primary Uveal Melanoma

Published in: Molecular Cancer Therapeutics Authors: Rhonda C. Kines, Isabella Varsavsky, Sanghamitra Choudhary, Debaditya Bhattacharya, Sean Spring, Roger McLaughlin, Shin J. Kang, Hans E. Grossniklaus, Demetrios Vavvas, Stephen Monks, John R. MacDougall, Elisabet de los Pinos, and John T. Schiller    Published in: Molecular Cancer Therapeutics Authors: Rhonda C. Kines, Isabella Varsavsky, Sanghamitra Choudhary, Debaditya Bhattacharya, Sean Spring, Roger McLaughlin, Shin J. Kang, Hans E. Grossniklaus, Demetrios Vavvas, Stephen Monks, John R. MacDougall, Elisabet de los Pinos, and John T. Schiller   The research group studied a novel recombinant papillomavirus-like particle (VLP) drug conjugate and its initial evaluation as a potential treatment for primary uveal melanoma. Laser was used for evaluating tumor-specific targeting and cellular toxicity of their novel IRDye 700DX-conjugated papillomavirus-like particle (AU-011) in vitro Continue reading →