Tag: tumor

Modulight Spotlights: LASER-SHARP RESEARCH – February 2026

Laser-sharp Research / antibodies, Cancer therapy, laser therapy, laser-sharp research, ML7710, next generation therapies, peptides, Photoimmunotherapy, tumor / February 27, 2026

Modulight Spotlights: LASER-SHARP RESEARCH – February 2026 This month, we are highlighting promising work by Professor Hirofumi Hanaoka’s team at Kansai Medical University, Photo-ImmunoTherapy Research Institute. They developed a novel peptide-based photoimmunotherapy drug that targets PD-L1, which is expressed on many types of cancer cells. Preclinical experiments showed significant suppression of tumor growth and an [...]

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Modulight Spotlights: LASER-SHARP RESEARCH – December 2025

Laser-sharp Research / imaging, in vitro, in vivo, laser-sharp research, ML6600, multi-wavelength, oxygen, Photodynamic therapy, treatment guidance, treatment monitoring, tumor, ultrasound / December 30, 2025

Deeksha Sankepalle and the group at Tufts University, USA developed an advanced multi-wavelength photoacoustic imaging system. It integrates a pulsed, tunable laser with an ultrasound acquisition platform to provide functional 3D imaging. The system enables real-time, non-invasive, high-resolution imaging of tumor vasculature by tracking oxygen saturation in the tumor.

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Modulight Spotlights: LASER-SHARP RESEARCH – November 2025

Laser-sharp Research / cancer, chemotherapy, drug delivery, glioblastoma, in vitro, laser-sharp research, ML8500, multidrug resistance, photoactivated chemotherapy, Photoimmunotherapy, preclinical, therapy resistance, tumor, University of Maryland, verteporfin / November 19, 2025

Modulight Spotlights: LASER-SHARP RESEARCH – November 2025 We are delighted to highlight new exciting study by Rahman et al. from Dr. Huang-Chiao Huang’s lab at University of Maryland. Multidrug resistance remains a significant barrier to successful chemotherapy outcomes for cancer patients, often caused by active pumping of chemotherapeutics outside of cancer cells. Hence, the team

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Interleukin 15 (IL15)-based near-infrared photoimmunotherapy

Scientific papers / 690 nm, in vitro, in vivo, interleukin15, IR700, light activation, ML7710, National Cancer Institute, NIH, NIR, Photoimmunotherapy, PIT, tumor / August 31, 2025

Published in: Cancer Immunology, Immunotherapy Authors: Motofumi Suzuki, Aki Furusawa, Hiroshi Yamamoto, Makoto Kano, Miyu Kano, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi

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Impact of Vitamin C on Immune Response and Edema Following Near-Infrared Photoimmunotherapy (NIR-PIT)

Scientific papers / 690 nm, in vitro, in vivo, IR700, IRDye700DX, ML7710, NIR, PDT, Photoimmunotherapy, tumor / April 17, 2025

Published in: Cancer Science Authors: Hiroshi Yamamoto, Aki Furusawa, Hiroshi Fukushima, Seiichiro Takao, Motofumi Suzuki, Makoto Kano, Miyu Kano, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi

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Liquid metal nanoparticles for enhanced delivery of benzoporphyrin derivative in photodynamic cancer therapy

Scientific papers / 690 nm, Cancer therapy, imaging, in vitro, ML6600, nanoparticles, PDT, Photodynamic therapy, photosensitizer, phototoxicity, tumor / April 15, 2025

Published in: Photochemistry and Photobiology Authors: Sumeyra Gokalp, Marvin Xavierselvan, Mohammad Forhad Khan, Ronak Shethia, Sima Khani, Ryan H. Riddell, Anna V. Krasnoslobodtseva, Srivalleesha Mallidi, Michelle Foster

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Modulight Spotlights: LASER-SHARP RESEARCH – February 2025

Laser-sharp Research / breast cancer, cancer, Cancer therapy, cancer treatment, immunology, immunotherapy, in vitro, in vivo, laser-sharp research, ML6600, photosensitizer, research, tumor, verteporfin / February 17, 2025

A. Lepland and the teams at University of Tartu, Estonia and Veneto Institute of Oncology, Italy, developed a new immunotherapy for triple negative breast cancer, using Modulight ML6000-series laser. Tumor growth slowed down and the cancer’s spreading to the lungs was suppressed.

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Peptide-Drug Conjugate for Therapeutic Reprogramming of Tumor-Associated Macrophages in Breast Cancer

Scientific papers / 689 nm, breast cancer, immunology, immunotherapy, in vitro, in vivo, ML6600, photosensitizer, tumor, verteporfin / January 22, 2025

Published in: Advanced Science Authors: Anni Lepland, Elisa Peranzoni, Uku Haljasorg, Eliana K. Asciutto, Maria Crespí-Amer, Lorenzo Modesti, Kalle Kilk, Manuel Lombardia, Gerardo Acosta, Miriam Royo, Pärt Peterson, Ilaria Marigo, Tambet Teesalu, Pablo Scodeller

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A Comprehensive Study of Reactive Oxygen Species Explicit Dosimetry for Pleural Photodynamic Therapy

Scientific papers / 630 nm, clinical, dosimetry, mesothelioma, ML7710, oxygen, PDT, Photodynamic therapy, photofrin, photosensitizer, pleural PDT, ROS detection, tumor / November 22, 2024

Published in: Antioxidants Authors: Hongjing Sun, Yihong Ong, Michele M. Kim, Andreea Dimofte, Sunil Singhal, Keith A. Cengel, Arjun G. Yodh, Timothy C. Zhu

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