Tag Archives: SPIM

Multimodal imaging microscope for tissue engineering applications

  Motivation for the study Tissue engineering is an evolving field of medicine that aims to grow new viable tissue for repairing or regenerating damaged tissues in the body. These tissue constructs are typically made by placing cells in support matrices that have proper growth-inducing factors. However, visualizing the development and composition of these tissue constructs is challenging with currently available optical imaging methods: they are either not capable of producing 3D images at sufficient depth or lack the bright-field imaging functionality. To answer this Continue reading →Customer case Research by: Computational biophysics and imaging research group at Tampere University. Research topics include development of bioimaging, analysis and biophysics based in-silico tools for new personalized treatments and diagnostics. Modulight products: ML6600 (488, 561, and 635 nm) Laser use: Light source for in-house built multimodal 3D imaging microscope used for imaging tissue engineering processes and products.   Professor Jari Hyttinen     Link to the study:   Toni Montonen, Doctoral Researcher     Motivation for the study Tissue engineering is an evolving field of Continue reading →

Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels

Published in: Materials Science & Engineering C Authors: Kaisa Vuornos, Miina Ojansivu, Janne T. Koivisto, Heikki Häkkänen, Birhanu Belay, Toni Montonen, Heini Huhtala, Minna Kääräinen, Leena Hupa, Minna Kellomäki, Jari Hyttinen, Janne A. Ihalainen, Susanna Miettinen    Published in: Materials Science & Engineering C Authors: Kaisa Vuornos, Miina Ojansivu, Janne T. Koivisto, Heikki Häkkänen, Birhanu Belay, Toni Montonen, Heini Huhtala, Minna Kääräinen, Leena Hupa, Minna Kellomäki, Jari Hyttinen, Janne A. Ihalainen, Susanna Miettinen   Laser was used as a light source for in-house-built Selective Plane Illumination Microscopy (SPIM) multimodal system for fluorescence imaging to study activation process of stem cell osteogenesis in hydrogels for bone constructs.   Read the article here