Tag Archives: research

Carrier-Free, Amorphous Verteporfin Nanodrug for Enhanced Photodynamic Cancer Therapy and Brain Drug Delivery

March 6, 2024 by Modulight Content
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Published in: Advanced Science Authors: John A. Quinlan, Collin T. Inglut, Payal Srivastava, Idrisa Rahman, Jillian Stabile, Brandon Gaitan, Carla Arnau Del Valle, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Baktiar Karim, Nina Connolly, Robert W. Robey, Graeme F. Woodworth, Michael M. Gottesman, Huang-Chiao Huang University of Maryland  Published in: Advanced Science Authors: John A. Quinlan, Collin T. Inglut, Payal Srivastava, Idrisa Rahman, Jillian Stabile, Brandon Gaitan, Carla Arnau Del Valle, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Baktiar Karim, Nina Connolly, Robert W. Robey, Graeme F. Woodworth, Michael M. Gottesman, Huang-Chiao Huang University of Maryland Glioblastoma (GBM) is hard to treat due to cellular invasion into functioning brain tissues, limited drug delivery, and evolved treatment resistance. Recurrence is nearly universal even after surgery, chemotherapy, and radiation. Photodynamic therapy (PDT) involves photosensitizer administration followed by light activation to generate reactive oxygen species at tumor sites, thereby killing cells or Continue reading →

Cyanine Phototruncation Enables Spatiotemporal Cell Labeling

June 13, 2022 by Modulight Content
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Published in: Journal of the American Chemical Society Authors: Hiroshi Fukushima, Siddharth S. Matikonda, Syed Muhammad Usama, Aki Furusawa, Takuya Kato, Lenka Štacková, Petr Klán, Hisataka Kobayashi, Martin J. Schnermann  Published in: Journal of the American Chemical Society Authors: Hiroshi Fukushima, Siddharth S. Matikonda, Syed Muhammad Usama, Aki Furusawa, Takuya Kato, Lenka Štacková, Petr Klán, Hisataka Kobayashi, Martin J. Schnermann In this study, phototruncation-assisted cell tracking (PACT) was developed to enable spatiotemporal tracking of immune cell populations in vivo. It is based on cyanine photoconversion reaction that leads to 2-carbon truncation and blue shift in the emission wavelength when irradiated with NIR light. ML6600 (780 nm) was used to induce photoconversion both in vitro and Continue reading →

Flow cytometry

March 28, 2022 by Modulight Content
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Introduction Flow cytometry is a widely used method in biomedical research and increasingly also in clinical diagnostics. It is a powerful and rapid technique to analyze physical and chemical properties of single cells or particles as they are suspended in liquid and pass in a narrow line across laser beams. Fluorescence together with scattered laser light is then filtered, detected, and analyzed on the other side of the sample. In addition to analysis, many flow cytometers can also sort and purify cell populations of interest Continue reading →Introduction Flow cytometry is a widely used method in biomedical research and increasingly also in clinical diagnostics. It is a powerful and rapid technique to analyze physical and chemical properties of single cells or particles as they are suspended in liquid and pass in a narrow line across laser beams. Fluorescence together with scattered laser light is then filtered, detected, and analyzed on the other side of the sample. In addition to analysis, many flow cytometers can also sort and purify cell populations of interest Continue reading →

Rising star in immunotherapy

September 15, 2015 by Seppo Orsila
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San Jose, California & Tampere FINLAND, September 15, 2015 – Modulight, Inc., a leading biomedical laser manufacturer, announces today a rising star in immunotherapy competition. The objective is to help clinicians and biomedical researchers below 35 years old to get their hands on the best possible tools to support photo immunotherapy. All clinicians, residents and biomedical researchers worldwide are eligible to participate the contest by submitting their application via web (research plan, CV and publication list). Final selection of the winner will be done by an independent board of Continue reading →

University & research centre discount program

September 8, 2014 by Modulight
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Good news for research groups at universities & research centres! To celebrate our success with medical systems and good improvement in our fiscal year profit, Modulight has launched a 2-month university discount program to demonstrate our commitment to support research and development in the field of laser medicine. Any qualifying customer that issues a new medical laser system order by the end of October 2014 will receive an automatic 10% discount.     PRODUCT LINKS | ML7710-PDT » | ML7700 turnkey laser platform » | ML6700-PDT laser modules » | Illumination kit »Good news for research groups at universities & research centres! To celebrate our success with medical systems and good improvement in our fiscal year profit, Modulight has launched a 2-month university discount program to demonstrate our commitment to support research and development in the field of laser medicine. Any qualifying customer that issues a new medical laser system order by the end of October 2014 will receive an automatic 10% discount.   Click here to get your discount!   PRODUCT LINKS | ML7710-PDT » | ML7700 turnkey laser platform » | ML6700-PDT laser modules » | Illumination kit »