Tag Archives: photothermal therapy

Photothermal therapy with platinum nanoparticles

Photothermal therapy efficiency Human ovarian cancer cells were plated on Petri dishes and incubated with platinum nanoparticles of varying sizes between 30 and 70 nm. After 24-hour incubation, irradiation was performed using a Modulight ML6600 laser at 808 nm together with an illumination kit (MLAKIT) tailored for Petri dish illumination. A small area of the dish was illuminated with the laser for five minutes with 45 W/cm2 irradiance. Calcein cell viability staining was performed 24 hours after the laser treatment and cells were examined with a Continue reading →Customer case Experimental Biophysics and Optical Manipulation research group studies biophysical properties of the cells using advanced optical techniques like optical trapping and nanoscale thermoplasmonics. Biophysical studies include the dynamics of plasma membrane, the effect of proteins on the membrane mechanisms of plasma membrane ruptures. Another important research area is photothermal therapy (PTT) using near-infrared laser to heat metallic nanoparticles. This heating of nanoparticles is also studied to deliver RNA therapeutics into the tumor tissue.  PET imaging is used to monitor treatment effects. Modulight products: ML6600 Continue reading →

Theranostic Prospects of Graphene Quantum Dots in Breast Cancer

Published in: ACS Biomaterials Science and Engineering Authors: Rahul S. Tade, Pravin O. Patil  Published in: ACS Biomaterials Science and Engineering Authors: Rahul S. Tade, Pravin O. Patil   Breast cancer (BC) is increasing as a significant cause of mortality among women. In this context, early diagnosis and treatment strategies for BC are being developed by researchers at the cellular level using advanced nanomaterials. However, immaculate etiquette is the prerequisite for their implementation in clinical practice. Considering the stolid nature of cancer, combining diagnosis and therapy (theranostics) using graphene quantum dots (GQDs) is a prime focus and challenge for Continue reading →

Effects and side-effects of plasmonic photothermal therapy in brain tissue

Published in: Cancer Nanotechnology Authors: Yue He, Kristoffer Laugesen, Dana Kamp, Salik Ahmad Sultan, Lene Broeng Oddershede, Liselotte Jauffred    Published in: Cancer Nanotechnology Authors: Yue He, Kristoffer Laugesen, Dana Kamp, Salik Ahmad Sultan, Lene Broeng Oddershede, Liselotte Jauffred   Laser was used for plasmonic photothermal therapy (PPTT) studies using gold nanoshells in brain tissue phantom and different porcine cerebral tissues. The electromagnetic field of a laser beam resonates with the plasmonic field of the nanoparticles, which absorb the incident light. The absorbed energy is dissipated as heat and causes hyperthermia in tumor.   Read the article here

Platinum nanoparticles: a non-toxic, effective and thermally stable alternative plasmonic material for cancer therapy and bioengineering

Published in: Nanoscale Authors: Akbar Samadi, Henrik Klingberg, Liselotte Jauffred, Andreas Kjær, Poul Martin Bendix, Lene B. Oddershede    Published in: Nanoscale Authors: Akbar Samadi, Henrik Klingberg, Liselotte Jauffred, Andreas Kjær, Poul Martin Bendix, Lene B. Oddershede   They have used laser to study effectiveness of platinum nanoparticles (PtNPs) for photothermal cancer therapy using ovarian cancer cell lines. They demonstrated that PtNPs are non-toxic themselves but upon laser irradiation kill effectively cancer cells.   Read the article here