Tag Archives: NIR

Cyanine Phototruncation Enables Spatiotemporal Cell Labeling

June 13, 2022 by Modulight Content
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Published in: Journal of the American Chemical Society Authors: Hiroshi Fukushima, Siddharth S. Matikonda, Syed Muhammad Usama, Aki Furusawa, Takuya Kato, Lenka Štacková, Petr Klán, Hisataka Kobayashi, Martin J. Schnermann  Published in: Journal of the American Chemical Society Authors: Hiroshi Fukushima, Siddharth S. Matikonda, Syed Muhammad Usama, Aki Furusawa, Takuya Kato, Lenka Štacková, Petr Klán, Hisataka Kobayashi, Martin J. Schnermann In this study, phototruncation-assisted cell tracking (PACT) was developed to enable spatiotemporal tracking of immune cell populations in vivo. It is based on cyanine photoconversion reaction that leads to 2-carbon truncation and blue shift in the emission wavelength when irradiated with NIR light. ML6600 (780 nm) was used to induce photoconversion both in vitro and Continue reading →

Photothermal therapy with platinum nanoparticles

August 16, 2021 by Modulight Content
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Photothermal therapy efficiency Human ovarian cancer cells were plated on Petri dishes and incubated with platinum nanoparticles of varying sizes between 30 and 70 nm. After 24-hour incubation, irradiation was performed using a Modulight ML6600 laser at 808 nm together with an illumination kit (MLAKIT) tailored for Petri dish illumination. A small area of the dish was illuminated with the laser for five minutes with 45 W/cm2 irradiance. Calcein cell viability staining was performed 24 hours after the laser treatment and cells were examined with a Continue reading →Customer case Experimental Biophysics and Optical Manipulation research group studies biophysical properties of the cells using advanced optical techniques like optical trapping and nanoscale thermoplasmonics. Biophysical studies include the dynamics of plasma membrane, the effect of proteins on the membrane mechanisms of plasma membrane ruptures. Another important research area is photothermal therapy (PTT) using near-infrared laser to heat metallic nanoparticles. This heating of nanoparticles is also studied to deliver RNA therapeutics into the tumor tissue.  PET imaging is used to monitor treatment effects. Modulight products: ML6600 Continue reading →