Published in: Molecular Pharmaceutics Authors: Puja Gangurde, Mohammad Mahmoudzadeh, Zahra Gounani, Artturi Koivuniemi, Patrick Laurén, Tatu Lajunen, Timo Laaksonen
Presented in: SPIE BIOS 2023 Authors: Laura Vesala, Robert Perttilä, Elias Kokko, Johannes Kivelä, Lasse Orsila, Petteri Uusimaa
Light-induced cytotoxicity in cells utilizing an automated well plate illuminator Read More »
Published in: Cancers Authors: Kensuke Kaneko, Hiroshi Nagata, Xiao-Yi Yang, Joshua Ginzel, Zachary Hartman, Jeffrey Everitt, Philip Hughes, Timothy Haystead, Michael Morse, Herbert Kim Lyerly, Takuya Osada
Presented in: SPIE BIOS 2022 Authors: Laura Vesala, Robert Perttilä, Elias Kokko, Lasse Orsila, Modulight Corporation (Finland), Tampere Univ. Hospital (Finland); Petteri Uusimaa, Modulight Corporation (Finland)
Light-activated drug release using an automated well plate illuminator Read More »
Motivation of the study In photodynamic therapy (PDT), systemically administered photosensitizer is activated within the tumor using focused near-infrared light, typically a laser with a wavelength matching the absorption peak of the photosensitizer. Several photosensitizers have been clinically approved for the treatment of different cancers; however, their accumulation is non-tumor exclusive which exposes healthy tissues
Development of heat shock protein 90-targeted PDT for inflammatory breast cancer Read More »
Sherri McFarland discussing how ML8500 is supporting her research Study protocol to determine wavelength, fluence, and irradiance activities of Os-4T: Key observations Illumination parameters significantly affected the phototoxicity of Os-4T. The green light (525 nm) was more effective than the red light (630 nm) at lower fluences, while the maximal potency was
Published in: SPIE BIOS 2021 Authors: Robert Perttilä, John Roque III, Lasse Orsila, Zoe Ylöniemi, Elias Kokko, Colin G. Cameron, Sherri A. McFarland, Petteri Uusimaa
Towards high-throughput light-activated drug discovery using automated plate illuminator Read More »
Presented in: SPIE BIOS 2021 Authors: Elias Kokko, Robert Perttilä, Lasse Orsila, Zoe Ylöniemi, Johannes Kivelä, Petteri Uusimaa
Published in: Chemical Science Authors: Liubov M. Lifshits, A. Roque III, Prathyusha Konda, Susan Monro, Houston D. Cole, David von Dohlen, Susy Kim, Gagan Deep, Randolph P. Thummel, Colin G. Cameron, Shashi Gujar, Sherri A. McFarland
