Tag: ML7710 | Page 8

Combining photoimmunotherapy with immune checkpoint inhibition

Application Note / 689nm, in vivo, IRDye700, ML7710, National Cancer Institute, National Institutes of Health, NCI, NIH, oncology, Photoimmunotherapy, PIT, targeted agents / July 14, 2021

Motivation for the study The motivation was to study if photoimmunotherapy could enhance anti-tumor immunity when combined with immune checkpoint inhibition. CD44-targeted photoimmunotherapy was applied against poorly immunogenic, “cold” tumor and antitumor effect was studied alone and in combination with anti-PD-1 immune checkpoint inhibition. Sensitization of this “cold” tumor to immune checkpoint inhibition after photoimmunotherapy […]

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Light-emitting fabrics for dermatological diseases

Application Note / 635nm, actinic keratosis, dermatology, EMPV, glioma, immunotherapy, light-emitting fabrics, ML7710, oncology, OncoThAI, PDT, skin cancer, squamous cell carcinoma, University of Lille / June 26, 2021

Related Modulight products and Services Related Publications Light emitting fabrics for PDT: technology and results of clinical studies Serge R. Mordon, Elise Thecua, Fabienne Lecomte, Anne-Sophie Vignion-Dewalle, Pascal Deleporte, Cyril Maire, Henry Abi-Rached, Claire Vicentini, Theresa Hommel, R. Markus Szeimies, Laurent Mortier SPIE, 2019 Photodynamic Therapy Using a New Painless Light-Emitting

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Selective laser vaporization of polypropylene mesh in tissue

Application Note / 647nm, ex vivo, ML7710, pelvic prolapse, polypropylene mesh, pulsed laser, surgery, sutures, UNC Charlotte, University of North Carolina at Charlotte, urinary incontinence, vaporization / June 22, 2021

Motivation for the study Surgical mesh is used to treat female stress urinary incontinence (SUI) and transvaginal pelvic organ prolapse (POP). However, erosion of this synthetic, non-absorbable mesh is a common complication and in more than half of these cases, a surgical excision of the mesh in the operating room is required. The mesh

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ML7710 for photoimmunotherapy against regulatory T cells in tumors

Application Note / cancer, customer, in vivo, Kill cancer, ML7710, Modulight in science, National Cancer Institute, National Institutes of Health, NCI, NIH, oncology, Photoimmunotherapy / June 14, 2021

Results Tumor growth was significantly suppressed by photoimmunotherapy, compared to control or IgG without light activation. Tumor growth suppression, as well as overall survival after photoimmunotherapy, were significantly better with F(ab´)2 fragments than with full IgG. This efficacy improvement might be related to killer T cells, which were detected in much higher numbers

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Rapid Depletion of Intratumoral Regulatory T cells Induces Synchronized CD8 T and NK Cell Activation and IFN-γ-dependent Tumor Vessel Regression

Scientific papers / 690 nm, H&N cancer, head & neck cancer, in vivo, IR700, ML7710, Photoimmunotherapy, targeted photoimmunotherapy, tumor / June 1, 2021

Published in: Cancer Research Authors: Yutaka Kurebayashi, Colleen P. Olkowski, Kelly C. Lane, Olga V. Vasalatiy, Biying C. Xu, Ryuhei Okada, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi, Noriko Sato

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Modulight Spotlights: LASER-SHARP RESEARCH – May 2021

Laser-sharp Research / Kill cancer, laser-sharp research, lasers in science, ML7710, Modulight in science, Photoimmunotherapy / June 1, 2021

Modulight Spotlights: LASER-SHARP RESEARCH – May 2021 The renowned pioneer in photoimmunotherapy (PIT), Professor Hisataka Kobayashi, has published an outstanding article with his team at National Cancer Institute / NIH. The article is about improving the antitumor efficacy of near-infrared photoimmunotherapy (NIR-PIT) by simultaneous targeting of cancer cells and regulatory T cells in the tumor

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ML7710 for glioblastoma treatment

Application Note / 5-ALA, brain cancer, fluorescence-guided surgery, glioblastoma, ML7710, PDT, Photodynamic therapy, PPIX, reactive oxygen species, UKM, University Hospital Münster / May 25, 2021

Customer case Research by: University Hospital Münster provides cutting-edge medical treatments for patients all over the world. The department of neurosurgery provides a full spectrum of neurosurgical care with interdisciplinary vascular and neuro-oncological specialization. Modulight products: ML7710, ML7710i Laser use: Randomized controlled PDT trials for both newly diagnosed and recurrent glioblastoma, as well as compassionate care

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Development of heat shock protein 90-targeted PDT for inflammatory breast cancer

Application Note / 665 nm, 689 nm, 750 nm, breast cancer, Duke University, HS201, HSP90, in vitro, in vivo, ML7710, ML8500, verteporfin / May 17, 2021

Motivation of the study In photodynamic therapy (PDT), systemically administered photosensitizer is activated within the tumor using focused near-infrared light, typically a laser with a wavelength matching the absorption peak of the photosensitizer. Several photosensitizers have been clinically approved for the treatment of different cancers; however, their accumulation is non-tumor exclusive which exposes healthy tissues

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ML7710 for fluorescence imaging: Detection of colorectal polyps in humans using c-Met targeted fluorescent peptide

Application Note / cancer, clinical, colonoscopy, colorectal cancer, customer, diagnostics, fluorescence detection, fluorescence imaging, GE Healthcare, imaging, Leiden University Medical Center, ML7710, oncology, polyps, targeted agents / May 4, 2021

Motivation for the study Polyps are small growths on the inner lining of the colon or rectum, affecting around 1 in 4 people over the age of 50. Certain types of polyps may eventually become cancerous, and colon cancer prevention relies on colonoscopy using white light to detect and remove the polyps. However, small and

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