Tag Archives: ML6600

Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells

Published in: Cancer Letters Authors: Yan Baglo, Barry J. Liang, Robert W. Robey, Suresh V. Ambudkar, Michael M. Gottesman, Huang-Chiao Huang    Published in: Cancer Letters Authors: Yan Baglo, Barry J. Liang, Robert W. Robey, Suresh V. Ambudkar, Michael M. Gottesman, Huang-Chiao Huang   The study investigates the transport and retention of benzoporphyrin derivative (BPD) photosensitizers in cancer cells, focusing on the role of various ATP-binding cassette (ABC) transporters. The team studied PDT resistance mechanisms by activating BPD in cancer cell lines and subsequently determining the cell viabilities. The lipidation of BPD is shown to decrease its efflux from cells and increase PDT effectiveness.   Read the Continue reading →

Effects and side-effects of plasmonic photothermal therapy in brain tissue

Published in: Cancer Nanotechnology Authors: Yue He, Kristoffer Laugesen, Dana Kamp, Salik Ahmad Sultan, Lene Broeng Oddershede, Liselotte Jauffred    Published in: Cancer Nanotechnology Authors: Yue He, Kristoffer Laugesen, Dana Kamp, Salik Ahmad Sultan, Lene Broeng Oddershede, Liselotte Jauffred   Laser was used for plasmonic photothermal therapy (PPTT) studies using gold nanoshells in brain tissue phantom and different porcine cerebral tissues. The electromagnetic field of a laser beam resonates with the plasmonic field of the nanoparticles, which absorb the incident light. The absorbed energy is dissipated as heat and causes hyperthermia in tumor.   Read the article here

Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels

Published in: Materials Science & Engineering C Authors: Kaisa Vuornos, Miina Ojansivu, Janne T. Koivisto, Heikki Häkkänen, Birhanu Belay, Toni Montonen, Heini Huhtala, Minna Kääräinen, Leena Hupa, Minna Kellomäki, Jari Hyttinen, Janne A. Ihalainen, Susanna Miettinen    Published in: Materials Science & Engineering C Authors: Kaisa Vuornos, Miina Ojansivu, Janne T. Koivisto, Heikki Häkkänen, Birhanu Belay, Toni Montonen, Heini Huhtala, Minna Kääräinen, Leena Hupa, Minna Kellomäki, Jari Hyttinen, Janne A. Ihalainen, Susanna Miettinen   Laser was used as a light source for in-house-built Selective Plane Illumination Microscopy (SPIM) multimodal system for fluorescence imaging to study activation process of stem cell osteogenesis in hydrogels for bone constructs.   Read the article here

Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer

Published in: British Journal of Cancer Authors: Gal Shafirstein, David A. Bellnier, Emily Oakley, Sasheen Hamilton, Michael Habitzruther, Lawrence Tworek, Alan Hutson, Joseph A. Spernyak, Sandra Sexton, Leslie Curtin, Steven G. Turowski, Hassan Arshad, Barbara Henderson    Published in: British Journal of Cancer Authors: Gal Shafirstein, David A. Bellnier, Emily Oakley, Sasheen Hamilton, Michael Habitzruther, Lawrence Tworek, Alan Hutson, Joseph A. Spernyak, Sandra Sexton, Leslie Curtin, Steven G. Turowski, Hassan Arshad, Barbara Henderson   Currently delivered light dose (J/cm2) is the principal parameter guiding interstitial photodynamic therapy (I-PDT) of refractory locally advanced cancer. The aim of this study was to investigate the impact of light dose rate (irradiance, mW/cm2) and associated heating on tumour response and cure. Laser was used to activate Continue reading →

Platinum nanoparticles: a non-toxic, effective and thermally stable alternative plasmonic material for cancer therapy and bioengineering

Published in: Nanoscale Authors: Akbar Samadi, Henrik Klingberg, Liselotte Jauffred, Andreas Kjær, Poul Martin Bendix, Lene B. Oddershede    Published in: Nanoscale Authors: Akbar Samadi, Henrik Klingberg, Liselotte Jauffred, Andreas Kjær, Poul Martin Bendix, Lene B. Oddershede   Absorption of near infrared (NIR) light by metallic nanoparticles can cause extreme heating and is of interest for instance in cancer treatment since NIR light has a relatively large penetration depth into biological tissue. The research group has used laser to study effectiveness of platinum nanoparticles (PtNPs) for photothermal cancer therapy using ovarian cancer cell lines. They demonstrated that PtNPs are non-toxic themselves but upon laser Continue reading →

An Infrared Dye–Conjugated Virus-like Particle for the Treatment of Primary Uveal Melanoma

Published in: Molecular Cancer Therapeutics Authors: Rhonda C. Kines, Isabella Varsavsky, Sanghamitra Choudhary, Debaditya Bhattacharya, Sean Spring, Roger McLaughlin, Shin J. Kang, Hans E. Grossniklaus, Demetrios Vavvas, Stephen Monks, John R. MacDougall, Elisabet de los Pinos, and John T. Schiller    Published in: Molecular Cancer Therapeutics Authors: Rhonda C. Kines, Isabella Varsavsky, Sanghamitra Choudhary, Debaditya Bhattacharya, Sean Spring, Roger McLaughlin, Shin J. Kang, Hans E. Grossniklaus, Demetrios Vavvas, Stephen Monks, John R. MacDougall, Elisabet de los Pinos, and John T. Schiller   The research group studied a novel recombinant papillomavirus-like particle (VLP) drug conjugate and its initial evaluation as a potential treatment for primary uveal melanoma. Laser was used for evaluating tumor-specific targeting and cellular toxicity of their novel IRDye 700DX-conjugated papillomavirus-like particle (AU-011) in vitro Continue reading →

ML6600 – Cloud-powered Laser Solution Platform

ML6600 - Cloud-Powered Laser Solution PlatformML6600 is an established product platform, originally launched in 2013. ML6600 can host different laser technologies (diode, fiber, DPSS). Specifications will be tailored to the application. Wavelength in the range from UV to 2+ µm, power from mW up to 100 W, and linewidths down to kHz. Easy-to-integrate light engine ML6600 is a compact, easy-to-integrate laser solution that can be flexibly tailored to various applications, such as Flow Cytometry, Semiconductor Metrology, Quantum Computing, Diagnostics, Genetics, and various medical applications. It’s Continue reading →