Tag Archives: ML6600

AI-based laser alignment for Flow Cytometry

Next generation flow cytometry Lasers have been historically the key light sources utilized in flow cytometry due to their ability to deliver the precise amount of energy needed to trigger the Stokes shift, which is the key phenomena underlying flow cytometry operation. For the same reason lasers and optical system in general are referred to as the “heart of flow cytometer”, since they are the integral component initiating the instrument operation. To ensure smooth and repeatable flow cytometer performance laser source needs to exhibit excellent Continue reading →

Photobiomodulation for pain treatment using ML6600

Background Photobiomodulation with low-level laser or light therapy is an effective treatment for pain. It has various effects, such as analgesic (pain-relieving) effects, anti-inflammatory effects, tissue regeneration promoting effects, and wound healing effects. Photobiomodulation can be used to relief both acute and chronic pain and has the advantage of being noninvasive and safe. Earlier studies have shown that photobiomodulation affects the activity of pain-transmitting nerves, even though the mechanisms are not fully understood. Because lasers are scattered and absorbed by biological tissues, the laser intensity Continue reading →Customer case University of Toyama is a Japanese national university located in Toyama City and Takaoka City and established in 1949. It is comprised of 3 former national universities Toyama University, Toyama Medical and Pharmaceutical University, and Takaoka National College. Naoya Ishibashi Daisuke Uta Modulight products: ML6600 Laser use: Studying pain treatment with photobiomodulation. Links to articles:     Background Photobiomodulation with low-level laser or light therapy is an effective treatment for pain. It has various effects, such as analgesic (pain-relieving) effects, anti-inflammatory effects, tissue regeneration Continue reading →

Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells

Published in: eBioMedicine Authors: Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S. Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L. Choyke, Martin J. Schnermann, Hisataka Kobayashi  Published in: eBioMedicine Authors: Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S. Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L. Choyke, Martin J. Schnermann, Hisataka Kobayashi A new method called phototruncation-assisted cell tracking (PACT) can be used to noninvasively track migration of immune cells to understand anti-cancer immunity mechanisms. PACT is based on irreversible photo-induced truncation reaction, transforming Cy7 into Cy5 when exposed to NIR light (780 nm). PACT was used in this study to monitor spatiotemporal migration of immune cells between tumor and Continue reading →

Development of thermosensitive liposomes with the help of ML8500

Background The proper delivery and release of therapeutic drugs to a specific site or cell type is one of the main challenges in the treatment of diseases. Liposomes, which are vesicles composed of lipids, serve as carriers for drug delivery thanks to their long circulation time. This results to reduced toxicity in healthy tissues and improved therapeutic efficacy of encapsulated drugs. However, conventional liposomes can often be even too stabile, leading to insufficient drug release at the target site. Light activation can offer a solution Continue reading →Customer case Pharmaceutical Nanotechnology led by Professor Timo Laaksonen on controlled drug release and delivery using modern methods and materials. Particular interest lies in using light to both monitor nanomaterial behavior and to trigger e.g. drug release processes. Modulight products: ML8500, ML6600, MLAKIT Prof. Timo Laaksonen Dr. Tatu Lajunen Laser use: Light-triggered drug release studies from light-activated liposomes. ML8500 with 808 nm wavelength was used to induce the release of calcein from liposomes under different temperatures. The effect of different type of lipids on liposomal Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – March 2024

 Modulight Spotlights: LASER-SHARP RESEARCH – March 2024 Glioblastoma is the most aggressive type of brain tumor. It is hard to treat because of its invasion into functioning brain tissues, limited drug delivery due to blood-brain-barrier, and evolved treatment resistance. To address these challenges, a light-activated nanoformulation, called nanoVP, was developed for glioblastoma in a new study co-led by John Quinlan and Collin Inglut in Dr. Huang’s team at the University of Maryland. Published in a prestigious journal Advanced Science, this novel therapy resulted in an improved tumor control and survival Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – February 2024

 Modulight Spotlights: LASER-SHARP RESEARCH – February 2024 Photoactivated chemotherapy (PACT) is a novel anticancer therapy where cytotoxic drug is attached into a photocage, which is cleaved by light to release the drug at the tumor site. A new study led by Prof. Sylvestre Bonnet’s group at Leiden University, demonstrated a significantly improved agent for photoactivated chemotherapy. ML6600 laser was used to study the drug release from the photocage, comparing efficacy between red and green light. It was shown that the agent could be effectively released Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – January 2024

 Modulight Spotlights: LASER-SHARP RESEARCH – January 2024 Phototherapy is widely established treatment for skin diseases like actinic keratosis, cutaneous infections, and skin tumors, resulting in excellent cosmetic outcomes. However, some clinically used light sensitizing drugs have drawbacks such as limited penetration depth and high painfulness to patient. In a new study by Andreea Burloiu and the teams at Carol Davila University of Medicine and Pharmacy, new photoactivated drugs were developed for treatment of skin diseases. ML6600 laser with MLAKIT was used to evaluate the effect Continue reading →

Hyperspectral imaging for flow cytometry

Published in: SPIE BIOS 2024 Authors: Anna Filipchuk, Robert Perttilä, Ana Colucci, Petteri Uusimaa  Published in: SPIE BIOS 2024 Authors: Anna Filipchuk, Robert Perttilä, Ana Colucci, Petteri Uusimaa Flow cytometry is a widely used analysis technique in biomedical sciences. It has found extensive utilization in both clinical diagnostics and cutting-edge biological research. As the method has been gaining greater recognition, its underlying technologies have undergone rapid development to further expand its range of applications. A notable trend is the introduction of imaging modalities to flow cytometry to expand the information content of the analyzed sample.   Read the article Continue reading →

Distributed Bragg Reflector (DBR) Laser Diodes

Introduction to DRB lasers Distributed Bragg Reflector (DBR) laser diodes are a class of single-frequency monolithic semiconductor lasers. Monolithic semiconductor lasers in general are small in size, mechanically robust, and have good power conversion efficiency. They also provide opportunities for hybrid integration with photonic integrated circuits (PICs). This application note provides an overview of DBR lasers, their principles of operation, their modal behavior, and their diverse applications. Principles of DBR Laser Operation A DBR laser is a semiconductor laser with one or several quantum wells Continue reading →

Modulight launches ML6600 for Flow Cytometry and Quantum Computing

Next week at Photonics West 2024, Modulight will unveil significant new additions to the ML6600 laser solution platform. These new innovations include a specialized laser engine tailored for Flow Cytometry applications, and advanced DBR laser cores designed specifically for the Quantum Computing market. Our #LaserFamily are presenting 11 conference papers plus participating in a technical panel, across the Photonics West conferences BIOS, OPTO, LASE and QUANTUM WEST. You can see the list here. ML6600 for Flow Cytometry – Laser engine with active beam steering The newest product utilizing the ML6600 platform is a specialized laser engine for the Continue reading →Next week at Photonics West 2024, Modulight will unveil significant new additions to the ML6600 laser solution platform. These new innovations include a specialized laser engine tailored for Flow Cytometry applications, and advanced DBR laser cores designed specifically for the Quantum Computing market. Our #LaserFamily are presenting 11 conference papers plus participating in a technical panel, across the Photonics West conferences BIOS, OPTO, LASE and QUANTUM WEST. You can see the list here. ML6600 for Flow Cytometry – Laser engine with active beam steering The newest product utilizing the ML6600 platform is a specialized laser engine for the Continue reading →