Tag Archives: ML6600

Light-induced drug delivery with indocyanine green liposomes

Introduction to light-controlled drug delivery systems Study description It is important that light-triggered liposomes efficiently release their contents, while the liposome stability should be maintained in the absence of laser light. The aim of this study is to determine how liposomal stability and drug release are affected by liposomal formulation. Indocyanine green was used as the light-sensitizing compound in the liposomes since it is clinically approved light-sensitive agent. Three different liposomal formulations were prepared: Formulation A: ICG in the aqueous core, liposomes coated Formulation B: ICG in the liposomal Continue reading →Customer case Faculty of Pharmacy at University of Helsinki is specialized in top-level pharmaceutical research. Multidisciplinary research fields include clinical pharmacy, experimental drugs, nanomedicines, and pharmaceutical drug design. Drug delivery unit led by Professor Arto Urtti focuses on design and testing of advanced drug delivery systems especially for ocular indications. Light is studied as an important tool to control the drug delivery to the target tissues. Modulight products: ML6600 (810 nm) + Modulight in vitro illumination kit (MLAKIT) Professor Arto Urtti   Senior Pharmaceutical Researcher Tatu Continue reading →

Flow cytometry

Introduction Flow cytometry is a widely used method in biomedical research and increasingly also in clinical diagnostics. It is a powerful and rapid technique to analyze physical and chemical properties of single cells or particles as they are suspended in liquid and pass in a narrow line across laser beams. Fluorescence together with scattered laser light is then filtered, detected, and analyzed on the other side of the sample. In addition to analysis, many flow cytometers can also sort and purify cell populations of interest Continue reading →Introduction Flow cytometry is a widely used method in biomedical research and increasingly also in clinical diagnostics. It is a powerful and rapid technique to analyze physical and chemical properties of single cells or particles as they are suspended in liquid and pass in a narrow line across laser beams. Fluorescence together with scattered laser light is then filtered, detected, and analyzed on the other side of the sample. In addition to analysis, many flow cytometers can also sort and purify cell populations of interest Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – November 2021

     Modulight Spotlights: LASER-SHARP RESEARCH – November 2021 Dr. Aaron Sorrin and researchers at the University of Maryland found a new potential combination therapy for ovarian cancer. This combination includes a novel light-based technology, called photodynamic priming, and a targeted therapeutic against a specific cancer cell receptor, effectively suppressing invasion of cancer cells. Modulight’s scientific board wanted to highlight this research especially because novel therapeutic solutions are urgently needed against this aggressive disease, which despite the best possible current therapies, recurs in most patients leading to Continue reading →

Light penetration depth in brain with different photosensitizers

  Motivation for the study Glioblastoma is the most aggressive and lethal brain cancer with an average prognosis of 15 months. Fluorescence-guided surgery (FGS) for glioblastoma was FDA-approved in 2017, while photodynamic therapy (PDT) remains an active area of clinical investigation with very promising results so far. The aim of PDT is to eradicate the invasive cancer cells within 2 cm of the resected area where the glioblastoma most often recurs. However, a significant hurdle of this therapy modality is the limited light penetration depth Continue reading →Customer case Research by: University of Maryland, Optical Therapeutics & Nanotechnology Laboratory led by Prof. Huang. Research focuses on precision cancer nanomedicine, drug delivery strategies, overcoming cancer resistance, mechanism-based combination therapies, site-directed photochemistry and fluorescence diagnostics. Modulight has started a joint R&D program with Dr. Huang lab to study novel EGFR-targeted combination therapy/diagnostic agent PIC-Nal-IRI developed by Huang lab. Modulight products: ML6600 laser system (635 nm and 689 nm). Professor Huang-Chiao Huang Laser use: Targeted photodynamic therapy/photoimmunotherapy with benzoporphyrin derivative (BPD) & 5-aminolevulinic acid (5-ALA) photosensitizers. Continue reading →

Multimodal imaging microscope for tissue engineering applications

  Motivation for the study Tissue engineering is an evolving field of medicine that aims to grow new viable tissue for repairing or regenerating damaged tissues in the body. These tissue constructs are typically made by placing cells in support matrices that have proper growth-inducing factors. However, visualizing the development and composition of these tissue constructs is challenging with currently available optical imaging methods: they are either not capable of producing 3D images at sufficient depth or lack the bright-field imaging functionality. To answer this Continue reading →Customer case Research by: Computational biophysics and imaging research group at Tampere University. Research topics include development of bioimaging, analysis and biophysics based in-silico tools for new personalized treatments and diagnostics. Modulight products: ML6600 (488, 561, and 635 nm) Laser use: Light source for in-house built multimodal 3D imaging microscope used for imaging tissue engineering processes and products.   Professor Jari Hyttinen     Link to the study:   Toni Montonen, Doctoral Researcher     Motivation for the study Tissue engineering is an evolving field of Continue reading →

Photothermal therapy with platinum nanoparticles

Photothermal therapy efficiency Human ovarian cancer cells were plated on Petri dishes and incubated with platinum nanoparticles of varying sizes between 30 and 70 nm. After 24-hour incubation, irradiation was performed using a Modulight ML6600 laser at 808 nm together with an illumination kit (MLAKIT) tailored for Petri dish illumination. A small area of the dish was illuminated with the laser for five minutes with 45 W/cm2 irradiance. Calcein cell viability staining was performed 24 hours after the laser treatment and cells were examined with a Continue reading →Customer case Experimental Biophysics and Optical Manipulation research group studies biophysical properties of the cells using advanced optical techniques like optical trapping and nanoscale thermoplasmonics. Biophysical studies include the dynamics of plasma membrane, the effect of proteins on the membrane mechanisms of plasma membrane ruptures. Another important research area is photothermal therapy (PTT) using near-infrared laser to heat metallic nanoparticles. This heating of nanoparticles is also studied to deliver RNA therapeutics into the tumor tissue.  PET imaging is used to monitor treatment effects. Modulight products: ML6600 Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – June 2021

Modulight Spotlights: LASER-SHARP RESEARCH – June 2021 The findings by Prof. Lothar Lilge and his team might enable improved treatment of diffuse lung metastasis which are difficult to treat with standard therapies. A novel lung perfusion platform significantly reduced tissue absorption and allowed better light penetration, resulting in up to 3-fold increased treatment volumes.   Read original publication   Modulight is very happy to be supporting this research. We would like to deliver our warmest congratulations to the research team!   #LaserSharpResearch  #ModulightInScience   #LasersInScience Continue reading →