Modulight Spotlights: LASER-SHARP RESEARCH – February 2023
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ML6500
Light-induced drug delivery with indocyanine green liposomes
Introduction to light-controlled drug delivery systems Study description It is important that light-triggered liposomes efficiently release their contents, while the liposome stability should be maintained in the absence of laser light. The aim of this study is to determine how liposomal stability and drug release are affected by liposomal formulation. Indocyanine green was used as the light-sensitizing compound
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Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW
Published in: Frontiers in Oncology Authors: Chanda Bhandari, John Fakhry, Menitte Eroy, Jane Junghwa Song, Kimberley Samkoe, Tayyaba Hasan, Kenneth Hoyt, Girgis Obaid
Modulight Spotlights: LASER-SHARP RESEARCH – February 2022
The positive effects of blue light cystoscopy could extend beyond visualization and result in the induction of systemic antitumor immunity, which can be further boosted with immune checkpoint inhibitors.
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Antitumor Effect and Induced Immune Response Following Exposure of Hexaminolevulinate and Blue Light in Combination with Checkpoint Inhibitor in an Orthotopic Model of Rat Bladder Cancer
Published in: Biomedicines Authors: Laureline Lamy, Jacques Thomas, Agnès Leroux, Jean-François Bisson, Kari Myren, Aslak Godal, Gry Stensrud, Lina Bezdetnaya
Light delivery optimization for H&N cancer treatment
Results Illumination with one fiber Some level of tissue heating was observed at all used light intensities. At lower intensities (60-100 mW/cm), less than 5% of the tumor was subjected to >60 ⁰C temperature, a point where irreversible thermal damage will immediately occur (photothermal ablation). At intensities of 150-200 mW/cm, 15-20% of the tumor was
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Protected: New approach for targeted PDT of glioblastoma
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