Tag Archives: liposomes

Medical laser platform to induce and monitor drug release from nano-constructs in vitro and in vivo

March 5, 2021 by Modulight Content
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Presented in: SPIE BIOS 2021 Authors: Zoe Ylöniemi, Johannes Kivelä, Elias Kokko, Robert Perttilä, Visa Kaivosoja, Lasse Orsila, Petteri Uusimaa    Presented in: SPIE BIOS 2021 Authors: Zoe Ylöniemi, Johannes Kivelä, Elias Kokko, Robert Perttilä, Visa Kaivosoja, Lasse Orsila, Petteri Uusimaa Fighting cancer involves more and more combination of modalities and drugs to maximize the long-term tumor resistance and cure. The rationale for combination therapy is to use treatment modalities or drug combinations that work by different mechanisms, decreasing the likelihood that resistant cancer cells will develop. The combination of light induced therapy like photodynamic therapy (PDT) and chemotherapy has the potential to overcome the limitations traditionally associated with light-based therapies and Continue reading →

Breaking the selectivity‑uptake trade‑off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi‑tier cancer targeting

January 2, 2020 by Modulight Content
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Published in: Journal of Nanobiotechnology Authors: Barry J. Liang, Michael Pigula, Yan Baglo, Daniel Najafali , Tayyaba Hasan, Huang‑Chiao Huang    Published in: Journal of Nanobiotechnology Authors: Barry J. Liang, Michael Pigula, Yan Baglo, Daniel Najafali , Tayyaba Hasan, Huang‑Chiao Huang   The ML6600 laser was used to test the PDT efficacy of a novel photoimmunoconjugate-nanoliposome (PIC-Nal) comprising of EGFR-targeted Cetuximab, BPD photosensitizer and irinotecan chemoterapy inside a liposome. Different cancer cell lines were used and cell viability was determined after PDT.   Read the article here

The effect of light sensitizer localization on the stability of indocyanine green liposomes

August 28, 2018 by Modulight Content
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Published in: Journal of Controlled Release Authors: Tatu Lajunen, Riikka Nurmi, Danny Wilbie, Teemu Ruoslahti, Niklas G. Johansson, Ossi Korhonen, Tomasz Rog, Alex Bunker, Marika Ruponen, Arto Urtti    Published in: Journal of Controlled Release Authors: Tatu Lajunen, Riikka Nurmi, Danny Wilbie, Teemu Ruoslahti, Niklas G. Johansson, Ossi Korhonen, Tomasz Rog, Alex Bunker, Marika Ruponen, Arto Urtti   Targeted delivery of drugs using external light trigger is feasible in light-accessible organs, e.g. eye and skin, and it may offer several benefits compared to passive drug leakage from the drug carrier. The research group has used ML6600 laser and illumination kit (MLAKIT) for light-triggered release studies of calcein from ICG liposomes to optimize the liposome composition Continue reading →