Tag Archives: lasers in science

Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids

February 6, 2024 by Modulight
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Published in: Cell & Bioscience Authors: Aaron Sorrin, Anika Dasgupta, Kathryn McNaughton, Carla Arnau Del Valle, Keri Zhou, Cindy Liu, Dana M. Roque & Huang Chiao Huang Within the last decade, poly(ADP-ribose) polymerase inhibitors (PARPi) have emerged in the clinic as an effective treatment for numerous malignancies. Preclinical data have demonstrated powerful combination effects of PARPi paired with photodynamic therapy (PDT), which involves light-activation of specialized dyes (photosensitizers) to stimulate cancer cell death through reactive oxygen species generation. In this study, a novel combination strategy was Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – July 2022

July 11, 2022 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – July 2022 Modulight congratulates Dr. Makoto Mitsunaga et al. Jikei University School of Medicine for publishing their promising results in Communications Biology journal. The team developed a next-generation light-based approach to tackle pathogens, called photoimmuno-antimicrobial strategy (PIAS). This technology was shown to eliminate a broad spectrum of different classes of pathogens, such as viruses, fungi, and bacteria. Unlike antibiotics, PIAS was also effective against drug-resistant pathogens and didn’t damage natural, beneficial microbiota in the host’s tissues. As COVID-19 pandemic and Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – November 2021

December 7, 2021 by Modulight Content
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     Modulight Spotlights: LASER-SHARP RESEARCH – November 2021 Dr. Aaron Sorrin and researchers at the University of Maryland found a new potential combination therapy for ovarian cancer. This combination includes a novel light-based technology, called photodynamic priming, and a targeted therapeutic against a specific cancer cell receptor, effectively suppressing invasion of cancer cells. Modulight’s scientific board wanted to highlight this research especially because novel therapeutic solutions are urgently needed against this aggressive disease, which despite the best possible current therapies, recurs in most patients leading to Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – October 2021

November 1, 2021 by Modulight Content
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   Modulight Spotlights: LASER-SHARP RESEARCH – October 2021 This time we wanted to highlight Professor Tebello Nyokong’s team at Rhodes University, since their latest research tackles two big unmet needs in cancer therapy: tumor hypoxia and side effects of the drugs. The team designed multifunctional liposomes that can locally generate oxygen within tumors to alleviate hypoxia, which is a significant contributor to resistance to radio- and chemotherapies. These nanodrugs also hold the potential to reduce problematic side effects of standard cancer therapies as a result of Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – September 2021

October 1, 2021 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – September 2021 Laser-Sharp Research nomination goes to this month for Professor Kobayashi’s team and Dr. Noriko Sato’s team at National Cancer Institute, National Institute of Health, USA. Their research published in a prestigious Cancer Research journal showed that photoimmunotherapy can not only target tumor cells, but can also be harnessed to target body’s own tumor-promoting immune cells within the tumor. These special cells called intratumoral Tregs were selectively killed by photoimmunotherapy upon illumination with ML7710 laser, which led to activation Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – August 2021

September 1, 2021 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – August 2021 Modulight would like to congratulate Dr. Sabrina Oliveira and members of the Molecular Targeted Therapies research group at Utrecht University on their recent work published in Nanophotonics journal. They have developed nanobody-targeted phototherapy for feline oral carcinoma with high potency and specificity towards oral cancer cells. This is an important step towards treating cats with oral cancers for which there are currently no effective therapeutic options available in the veterinary clinics. This type of research overall is critical Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – July 2021

August 4, 2021 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – July 2021 Congratulations for Gina Manda and her team at Victor Babes National Institute of Pathology! Their genetic study unveiled a network of stress responses in tumor cells triggered by PDT. These results expand knowledge of different mechanisms behind therapy-induced cell death and treatment resistance. Read original publication   Modulight is very happy to be supporting this research. We would like to deliver our warmest congratulations to the research team!   #LaserSharpResearch  #ModulightInScience   #LasersInScience #KillCancer  #ColonCancer #Genetics     Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – June 2021

June 28, 2021 by Modulight Content
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Modulight Spotlights: LASER-SHARP RESEARCH – June 2021 The findings by Prof. Lothar Lilge and his team might enable improved treatment of diffuse lung metastasis which are difficult to treat with standard therapies. A novel lung perfusion platform significantly reduced tissue absorption and allowed better light penetration, resulting in up to 3-fold increased treatment volumes.   Read original publication   Modulight is very happy to be supporting this research. We would like to deliver our warmest congratulations to the research team!   #LaserSharpResearch  #ModulightInScience   #LasersInScience Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – May 2021

June 1, 2021 by Modulight Content
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Modulight Spotlights: LASER-SHARP RESEARCH – May 2021 The renowned pioneer in photoimmunotherapy (PIT), Professor Hisataka Kobayashi, has published an outstanding article with his team at National Cancer Institute / NIH. The article is about improving the antitumor efficacy of near-infrared photoimmunotherapy (NIR-PIT) by simultaneous targeting of cancer cells and regulatory T cells in the tumor microenvironment. Read original publication   Modulight is very happy to be supporting this research. We would like to deliver our warmest congratulations to the research team!   #LaserSharpResearch  #ModulightInScience   Continue reading →

Modulight Spotlights: LASER-SHARP RESEARCH – April 2021

May 7, 2021 by Modulight Content
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Modulight Spotlights: LASER-SHARP RESEARCH – April 2021 Dr. Rhonda Kines and the team at Aura Biosciences reported promising results of their VLP (virus-like particle) photosensitizer-conjugate eliciting strong and long-lasting anti-tumor immune responses, as well as potential to combine this agent with immune checkpoint inhibitors for even improved antitumor efficacy. Read original publication   Modulight is very happy to be supporting this research. We would like to deliver our warmest congratulations to the research team!   #LaserSharpResearch #ModulightInScience   #LasersInScience #KillCancer #UvealMelanoma   Modulight products used: Continue reading →