Tag Archives: intratumoral

Intratumoral interleukin-15 improves efficacy of near-infrared photoimmunotherapy

Published in: Molecular Cancer Therapeutics Authors: Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Hiroaki Wakiyama, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi    Published in: Molecular Cancer Therapeutics Authors: Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Hiroaki Wakiyama, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi   Interleukin 15 (IL-15) is inducer of differentiation and proliferation of CD8+ T cells and NK cells and thus promising candidate for cancer immunotherapy. This study showed therapeutic efficacy increase in vivo when IL15 was combined with cancer cell-targeted photoimmunotherapy using ML7710 laser system. Intratumoral injection of IL-15 was more effective than intraperitoneal in suppressing tumor growth and inducing intratumoral immune responses, Continue reading →

Optimizing photosensitizer administration for cancer therapy

  Motivation While Photofrin PDT is an approved oncological therapy for multiple indications, its wider use is hindered by prolonged skin photosensitivity lasting several weeks. The aim of this study is to investigate intratumoral Photofrin administration as a way to decrease skin photosensitivity compared to the standard IV injection protocol. Tumor necrosis after PDT was assessed with immunohistochemical staining and Photofrin distributions by fluorescence microscopy.       Results   Anti-tumor efficacy was similar between intratumoral and IV administration; however, smaller doses of Photofrin were Continue reading →Customer case University of Rochester belongs among the nation’s top research universities. Research at the Baran lab focuses on anti-microbial PDT and optical image processing. The aim is to develop methods for utilizing quantitative information from CT, MR and PET imaging for PDT treatment planning as well as in the search of new biomarkers and therapeutic targets. Modulight products: ML7710 (630 & 665 nm) Link to the study: Timothy M. Baran (Ph.D., PI) Laser use: Ongoing clinical Phase 1 safety & feasibility study for methylene Continue reading →