Tag: in vitro | Page 8

In vitro illumination using ML8500: osmium-based anticancer photosensitizer with highest hypoxic activity reported to date

Application Note / drug discovery, in vitro, ML8500, photosensitizer, preclinical, University of Texas at Arlington / March 26, 2021

Sherri McFarland discussing how ML8500 is supporting her research Study protocol to determine wavelength, fluence, and irradiance activities of Os-4T: Key observations Illumination parameters significantly affected the phototoxicity of Os-4T. The green light (525 nm) was more effective than the red light (630 nm) at lower fluences, while the maximal potency was […]

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Towards high-throughput light-activated drug discovery using automated plate illuminator

Scientific papers / in vitro, Melanoma, ML8500, PDT, Photodynamic therapy, photosensitizer, Ruthenium / March 5, 2021

Published in: SPIE BIOS 2021 Authors: Robert Perttilä, John Roque III, Lasse Orsila, Zoe Ylöniemi, Elias Kokko, Colin G. Cameron, Sherri A. McFarland, Petteri Uusimaa

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Near-infrared Absorbing Ru(II) Complexes Act as Immunoprotective Photodynamic Therapy (PDT) Agents Against Aggressive Melanoma

Scientific papers / drug discovery, hypoxia, in vitro, Melanoma, ML8500, PDT, Ruthenium / September 9, 2020

Published in: Chemical Science Authors: Liubov M. Lifshits, A. Roque III, Prathyusha Konda, Susan Monro, Houston D. Cole, David von Dohlen, Susy Kim, Gagan Deep, Randolph P. Thummel, Colin G. Cameron, Shashi Gujar, Sherri A. McFarland

Near-infrared Absorbing Ru(II) Complexes Act as Immunoprotective Photodynamic Therapy (PDT) Agents Against Aggressive Melanoma Read More »

Breaking the barrier: an osmium photosensitizer with unprecedented hypoxic phototoxicity for real world photodynamic therapy

Scientific papers / 733 nm, hypoxia, in vitro, in vivo, ML8500, normoxia, Os-4T, PDT, Photodynamic therapy, photosensitizer / August 3, 2020

Published in: Chemical Science Authors: John A. Roque III, Patrick C. Barrett, Houston D. Cole, Liubov M. Lifshits, Ge Shi, Susan Monro, David von Dohlen, Susy Kim, Nino Russo, Gagan Deep, Colin G. Cameron, Marta E. Alberto, Sherri A. McFarland

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Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors

Scientific papers / 690 nm, breast cancer, HSP90, in vitro, ML7710, ML8500, PDT, Photodynamic therapy, preclinical, targeted therapies, verteporfin / May 8, 2020

Published in: Communications Biology Authors: Kensuke Kaneko, Takuya Osada, Michael A. Morse, William R. Gwin, Joshua D. Ginzel, Joshua C. Snyder, Xiao-Yi Yang, Cong-Xiao Liu, Márcio A. Diniz, Khaldon Bodoor, Philip F. Hughes, Timothy AJ. Haystead, H. Kim Lyerly

Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors Read More »

Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging

Scientific papers / 690 nm, in vitro, in vivo, IRDye700, IRDye700DX, ML7710, PDT, preclinical, targeted cancer PDT, targeted therapies / January 20, 2020

Published in: Theranostics Authors: Henriette S. de Bruijn, Vida Mashayekhi, Tom J.L. Schreurs, Pieter B.A.A. van Driel, Gustav J. Strijkers, Paul J. van Diest, Clemens W.G.M. Lowik, Ann L.B. Seynhaeve, Timo L.M. ten Hagen, Jeanine J. Prompers, Paul M.P. van Bergen en Henegouwen, Dominic J. Robinson, Sabrina Oliveira

Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging Read More »

Breaking the selectivity‑uptake trade‑off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi‑tier cancer targeting

Scientific papers / 690 nm, BPD, cancer, cetuximab, in vitro, liposomes, ML6600, PIC-Nal, targeted photoimmunotherapy, targeted therapies / January 2, 2020

Published in: Journal of Nanobiotechnology Authors: Barry J. Liang, Michael Pigula, Yan Baglo, Daniel Najafali , Tayyaba Hasan, Huang‑Chiao Huang

Breaking the selectivity‑uptake trade‑off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi‑tier cancer targeting Read More »

Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells

Scientific papers / 690 nm, benzoporphyrin derivative, BPD, breast, in vitro, ML6600, ML8500, PDT, Photodynamic therapy, photosensitizer / August 10, 2019

Published in: Cancer Letters Authors: Yan Baglo, Barry J. Liang, Robert W. Robey, Suresh V. Ambudkar, Michael M. Gottesman, Huang-Chiao Huang

Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells Read More »

Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels

Scientific papers / 488 nm, fluorescence imaging, in vitro, ML6600, SPIM, stem cells / February 13, 2019

Published in: Materials Science & Engineering C Authors: Kaisa Vuornos, Miina Ojansivu, Janne T. Koivisto, Heikki Häkkänen, Birhanu Belay, Toni Montonen, Heini Huhtala, Minna Kääräinen, Leena Hupa, Minna Kellomäki, Jari Hyttinen, Janne A. Ihalainen, Susanna Miettinen

Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels Read More »