Tag: in vitro | Page 5

Red-Light Activation of a Microtubule Polymerization Inhibitor via Amide Functionalization of the Ruthenium Photocage

Scientific papers / hypoxia, in vitro, in vivo, ML6600, oncology, PACT, photoactivated chemotherapy / December 7, 2023

Published in: Angew Chem Int Ed Authors: Ludovic Bretin, Yurii Husiev, Vadde Ramu, Liyan Zhang, Matthijs Hakkennes, Selda Abyar, Andrew C. Johns, Sylvia E. Le Dévédec, Tania Betancourt, Alexander Kornienko, Sylvestre Bonnet Leiden University A ruthenium-based compound was developed for PACT (photoactivated chemotherapy), which unlike most existing PACT compounds, can be also activated with clinically relevant [...]

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Modulight Spotlights: LASER-SHARP RESEARCH – November 2023

Laser-sharp Research / antibioticresistance, antimicrobial, Cell, drug resistance, in vitro, laser-sharp research, LaserSharpResearch, ML7710, verteporfin / November 14, 2023

Many infectious agents have developed resistance to antibiotics. To combat this problem, Professor Timothy Haystead’s team at Duke University developed a novel light-based antimicrobial strategy that targets non-essential enzyme on the surface of bacteria. Light activation was done using ML7710 with 693 nm laser light to generate reactive oxygen species that successfully sterilized the bacteria.

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Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development

Scientific papers / antimicrobial, Borrelia bugdorferi, Cell, drug resistance, enzyme, HtpG, in vitro, ML7710, verteporfin / November 1, 2023

Published in: Cell Chemical Biology Authors: Dave L. Carlson, Mark Kowalewski, Khaldon Bodoor, Matthew R. Redinbo, Neil Spector, Timothy A.J. Haystead Duke University

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Development of Robust Cationic Light-Activated Thermosensitive Liposomes: Choosing the Right Lipids

Scientific papers / 808 nm, in vitro, light activation, liposomes, ML8500, University of Helsinki / October 24, 2023

Published in: Molecular Pharmaceutics Authors: Puja Gangurde, Mohammad Mahmoudzadeh, Zahra Gounani, Artturi Koivuniemi, Patrick Laurén, Tatu Lajunen, Timo Laaksonen

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Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses

Scientific papers / antimicrobial, in vitro, in vivo, ML6600, ML7710, MRSA, Photoimmunotherapy, PIAS, PIT / October 4, 2023

Published in: Nature Protocols Authors: Tadayuki Iwase, Kimihiro Ito, Takashi Nishimura, Kei Miyakawa, Akihide Ryo, Hisataka Kobayashi, Makoto Mitsunaga The Jikei University School of Medicine

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Modulight Spotlights: LASER-SHARP RESEARCH – August 2023

Laser-sharp Research / abscopaleffects, combinationtherapy, IL15, immunotherapy, in vitro, in vivo, interleukin15, ML7710, NK cells, Photoimmunotherapy, T cells / August 24, 2023

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Intratumoral interleukin-15 improves efficacy of near-infrared photoimmunotherapy

Scientific papers / 690 nm, colon cancer, IL-15, immunotherapy, in vitro, in vivo, interleukin, intratumoral, ML7710, pancreatic cancer, Photoimmunotherapy / July 18, 2023

Published in: Molecular Cancer Therapeutics Authors: Hiroshi Fukushima, Aki Furusawa, Takuya Kato, Hiroaki Wakiyama, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi

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Transient fluid flow improves photoimmunoconjugate delivery and photoimmunotherapy efficacy

Scientific papers / 690 nm, benzoporphyrin, cetuximab, drug delivery, in vitro, liposomes, ML6600, oncology, ovarian cancer, PDT, peritoneal cavity, photoimmunoconjugates, Photoimmunotherapy, photosensitizer / June 26, 2023

Published in: iScience Authors: Aaron J. Sorrin, Keri Zhou, Katherine May, Cindy Liu, Kathryn McNaughton, Idrisa Rahman, Barry J. Liang, Imran Rizvi, Dana M. Roque, Huang-Chiao Huang

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Modulight Spotlights: LASER-SHARP RESEARCH – April 2023

Laser-sharp Research / Combination therapy, combinationtherapy, immunotherapy, in vitro, in vivo, laser-sharp research, ML6600, MLAKIT, Photoimmunotherapy, preclinical / April 13, 2023

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