Tag: in vitro | Page 4

Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells

Scientific papers / 690 nm, 780 nm, cancer, in vitro, in vivo, ML6600, ML7710, PACT, Photoimmunotherapy

Published in: eBioMedicine Authors: Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S. Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L. Choyke, Martin J. Schnermann, Hisataka Kobayashi

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Development of thermosensitive liposomes with the help of ML8500

Application Note / 808 nm, application note, drug delivery, drug discovery, illumination system, in vitro, indocyanine green, light activation, liposomes, ML6600, ML8500, MLAKIT, University of Helsinki

Background The proper delivery and release of therapeutic drugs to a specific site or cell type is one of the main challenges in the treatment of diseases. Liposomes, which are vesicles composed of lipids, serve as carriers for drug delivery thanks to their long circulation time. This results to reduced toxicity in healthy tissues and

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Photoimmuno-antimicrobial therapy for Staphylococcus aureus implant infection

Scientific papers / 690 nm, in vitro, in vivo, IRDye700, ML7710, Photoimmunotherapy, photosensitizer

Published in: PLoS One Authors: Bruce van Dijk, Sabrina Oliveira, J. Fred F. Hooning van Duyvenbode, F. Ruben H. A. Nurmohamed, Vida Mashayekhi, Irati Beltrán Hernández, Jos van Strijp, Lisanne de Vor, Piet C. Aerts, H. Charles Vogely, Harrie Weinans, Bart C. H. van der Wal

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Modulight Spotlights: LASER-SHARP RESEARCH – February 2024

Laser-sharp Research / hypoxia, in vitro, in vivo, laser-sharp research, ML6600, oncology, PACT, photoactivated chemotherapy

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Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids

Scientific papers / in vitro, lasers in science, ML8500, photosensitizer, well plate

Published in: Cell & Bioscience Authors: Aaron Sorrin, Anika Dasgupta, Kathryn McNaughton, Carla Arnau Del Valle, Keri Zhou, Cindy Liu, Dana M. Roque & Huang Chiao Huang Within the last decade, poly(ADP-ribose) polymerase inhibitors (PARPi) have emerged in the clinic as an effective treatment for numerous malignancies. Preclinical data have demonstrated powerful combination effects of PARPi

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Modulight Spotlights: LASER-SHARP RESEARCH – December 2023

Laser-sharp Research / cancer, in vitro, laser-sharp research, ML7710, photocatalysis, pollutant degradation, rhodamine 6g

Modulight Spotlights: LASER-SHARP RESEARCH – December 2023 Organic compounds are one of the leading causes of water pollution. Rhodamine 6G is a commonly used dye in the food and textile industries and can cause cancer when consumed in contaminated water. To tackle this problem, Professor T. Nyokong’s team at Rhodes University studied photocatalysis with ML7710 for

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Red-Light Activation of a Microtubule Polymerization Inhibitor via Amide Functionalization of the Ruthenium Photocage

Scientific papers / hypoxia, in vitro, in vivo, ML6600, oncology, PACT, photoactivated chemotherapy

Published in: Angew Chem Int Ed Authors: Ludovic Bretin, Yurii Husiev, Vadde Ramu, Liyan Zhang, Matthijs Hakkennes, Selda Abyar, Andrew C. Johns, Sylvia E. Le Dévédec, Tania Betancourt, Alexander Kornienko, Sylvestre Bonnet Leiden University A ruthenium-based compound was developed for PACT (photoactivated chemotherapy), which unlike most existing PACT compounds, can be also activated with clinically relevant

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Modulight Spotlights: LASER-SHARP RESEARCH – November 2023

Laser-sharp Research / antibioticresistance, antimicrobial, Cell, drug resistance, in vitro, laser-sharp research, LaserSharpResearch, ML7710, verteporfin

Many infectious agents have developed resistance to antibiotics. To combat this problem, Professor Timothy Haystead’s team at Duke University developed a novel light-based antimicrobial strategy that targets non-essential enzyme on the surface of bacteria. Light activation was done using ML7710 with 693 nm laser light to generate reactive oxygen species that successfully sterilized the bacteria.

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Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development

Scientific papers / antimicrobial, Borrelia bugdorferi, Cell, drug resistance, enzyme, HtpG, in vitro, ML7710, verteporfin

Published in: Cell Chemical Biology Authors: Dave L. Carlson, Mark Kowalewski, Khaldon Bodoor, Matthew R. Redinbo, Neil Spector, Timothy A.J. Haystead Duke University

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