Selective depletion of polymorphonuclear myeloid derived suppressor cells in tumor beds with near infrared photoimmunotherapy enhances host immune response
Published in: OncoImmunology Authors: Takuya Kato, Hiroshi Fukushima, Aki Furusawa, Ryuhei Okada, Hiroaki Wakiyama, Hideyuki Furumoto, Shuhei Okuyama, Seiichiro Takao, Peter L. Choyke, Hisataka Kobayashi Published in: OncoImmunology Authors: Takuya Kato, Hiroshi Fukushima, Aki Furusawa, Ryuhei Okada, Hiroaki Wakiyama, Hideyuki Furumoto, Shuhei Okuyama, Seiichiro Takao, Peter L. Choyke, Hisataka Kobayashi Myeloid-derived suppressor cells were selectively eliminated within tumors by Ly6G-targeted NIR-PIT, using ML7710 for in vitro and in vivo PIT. Significant tumor growth suppression and survival benefit, as well as abscopal effects, were observed in animal models, showing promise as a cancer immunotherapy. Read the article here