Tag: H&N cancer

Modulight Spotlights: LASER-SHARP RESEARCH – September 2023

Laser-sharp Research / 650 nm, bleomycin, drug delivery, fimaporfin, H&N cancer, head & neck cancer, HNSCC, laser-sharp research, ML6600, PCI, Photochemical Internalization, squamous cell carcinoma

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Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW

Scientific papers / 690 nm, BPD, cetuximab, fluorescence imaging, H&N cancer, in vivo, IRDye800CW, ML6500, Photoimmunotherapy, PIT, targeted therapies, tumor

Published in: Frontiers in Oncology Authors: Chanda Bhandari, John Fakhry, Menitte Eroy, Jane Junghwa Song, Kimberley Samkoe, Tayyaba Hasan, Kenneth Hoyt, Girgis Obaid

Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW Read More »

Light delivery optimization for H&N cancer treatment

Application Note / 630 nm, cancer, dosimetry, H&N cancer, head & neck cancer, in vivo, iPDT, ML6500, ML7710, oncology, PDT, Roswell Park

Results Illumination with one fiber Some level of tissue heating was observed at all used light intensities. At lower intensities (60-100 mW/cm), less than 5% of the tumor was subjected to >60 ⁰C temperature, a point where irreversible thermal damage will immediately occur (photothermal ablation). At intensities of 150-200 mW/cm, 15-20% of the tumor was

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Rapid Depletion of Intratumoral Regulatory T cells Induces Synchronized CD8 T and NK Cell Activation and IFN-γ-dependent Tumor Vessel Regression

Scientific papers / 690 nm, H&N cancer, head & neck cancer, in vivo, IR700, ML7710, Photoimmunotherapy, targeted photoimmunotherapy, tumor

Published in: Cancer Research Authors: Yutaka Kurebayashi, Colleen P. Olkowski, Kelly C. Lane, Olga V. Vasalatiy, Biying C. Xu, Ryuhei Okada, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi, Noriko Sato

Rapid Depletion of Intratumoral Regulatory T cells Induces Synchronized CD8 T and NK Cell Activation and IFN-γ-dependent Tumor Vessel Regression Read More »

Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer

Scientific papers / 630 nm, Barrett's esophagus, esophageal cancer, H&N cancer, head & neck cancer, high-grade dysplasia, in vivo, iPDT, Lung cancer, ML6600, ML7710, PDT, photofrin, preclinical

Published in: British Journal of Cancer Authors: Gal Shafirstein, David A. Bellnier, Emily Oakley, Sasheen Hamilton, Michael Habitzruther, Lawrence Tworek, Alan Hutson, Joseph A. Spernyak, Sandra Sexton, Leslie Curtin, Steven G. Turowski, Hassan Arshad, Barbara Henderson

Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer Read More »

Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial

Scientific papers / 652 nm, clinical, H&N cancer, head & neck cancer, ML7710, Phase 1, Photochemical internalisation, TPCS2a

Published in: Lancet Oncology Authors: Ahmed A Sultan, Waseem Jerjes, Kristian Berg, Anders Høgset, Charles A Mosse, Rifat Hamoudi, Zaid Hamdoon, Celia Simeon, Dawn Carnell, Martin Forster, Colin Hopper

Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial Read More »

EGFR targeted nanobody–photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer

Scientific papers / 690 nm, H&N cancer, head & neck cancer, IRDye700, ML7710, PDT, Photodynamic therapy, preclinical, targeted therapies

Published in: Journal of Controlled Release Authors: Pieter B.A.A. van Driel, Martin C. Boonstra, Maxime D. Slooter, Raimond Heukers, Marieke A. Stammes, Thomas J.A. Snoeks, Henriette S. de Bruijn, Paul J. van Diest, Alexander L. Vahrmeijer, Paul M.P. van Bergen en Henegouwen, Cornelis J.H. van de Velde, Clemens W.G.M. Löwik, Dominic J. Robinson, Sabrina Oliveira

EGFR targeted nanobody–photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer Read More »