Tag Archives: fluorescence imaging

Modulight Spotlights: LASER-SHARP RESEARCH – August 2022

August 10, 2022 by Modulight Content
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 Modulight Spotlights: LASER-SHARP RESEARCH – August 2022 Impressive research on head & neck cancer was published by Obaid Lab for molecular imaging and optical nanotherapeutics, at University of Texas, Dallas. The group used Modulight’s ML6500 for a subtherapeutic modulation of tumor microenvironment of H&N. This significantly improved delivery of molecular imaging agent to the tumors as well as improved diagnostic accuracy in detecting tumor tissue by fluorescence. Since incomplete resection and consequent recurrences are common problem with current H&N cancer treatment, this discovery answers unmet Continue reading →

Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW

June 28, 2022 by Modulight
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Published in: Frontiers in Oncology Authors: Chanda Bhandari, John Fakhry, Menitte Eroy, Jane Junghwa Song, Kimberley Samkoe, Tayyaba Hasan, Kenneth Hoyt, Girgis Obaid    Published in: Frontiers in Oncology Authors: Chanda Bhandari, John Fakhry, Menitte Eroy, Jane Junghwa Song, Kimberley Samkoe, Tayyaba Hasan, Kenneth Hoyt, Girgis Obaid   The study showed that photodynamic priming (subtherapeutic doses of light using ML6500) of tumor microenvironment with nanoliposomal BPD is highly beneficial for delivery of antibodies (Cet-IR800) to H&N tumor in mice. Priming significantly improved the tumor accumulation of Cet-IR800 and diagnostic accuracy of tumor detection, as monitored with fluroescence imaging.   Read the article here

Configurable multi-wavelength laser light engine for endoscopic fluorescence imaging

March 3, 2022 by Modulight
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Presented in: SPIE BIOS 2022 Authors: Zoe Ylöniemi, Visa Kaivosoja, Lasse Orsila, Tero Vierimaa, Petteri Uusimaa, Modulight Corporation (Finland)    Presented in: SPIE BIOS 2022 Authors: Zoe Ylöniemi, Visa Kaivosoja, Lasse Orsila, Tero Vierimaa, Petteri Uusimaa, Modulight Corporation (Finland)   Using different fluorescent dyes for clinical applications need endoscopic illumination sources with multiple wavelengths. Fluorescent imaging with simultaneous white light overlay image benefit from laser light sources for fluorescence excitation and white light illumination to allow for easy spectral filtering on imaging side. Imaging of complementary fluorescent dyes adds requirements for the light source. Modulight ML7710 oncology laser platform was developed to fulfill the requirements Continue reading →

ML7710 for fluorescence imaging: Detection of colorectal polyps in humans using c-Met targeted fluorescent peptide

May 4, 2021 by Modulight Content
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Motivation for the study Polyps are small growths on the inner lining of the colon or rectum, affecting around 1 in 4 people over the age of 50. Certain types of polyps may eventually become cancerous, and colon cancer prevention relies on colonoscopy using white light to detect and remove the polyps. However, small and flat polyps are difficult to detect and frequently missed with this technique. More precise methods to detect polyps before they progress to colorectal cancer are urgently needed. GE Healthcare’s patented EMI-137 Continue reading →Customer Case Research by: GE Healthcare is a manufacturer and distributor of diagnostic imaging agents and radiopharmaceuticals, R&D collaborations with Leiden University MC for early detection of colorectal tumors. Modulight products: ML7710 series clinical laser system (635 nm, 3 W) Laser use: Clinical single-wavelength laser device used for exciting novel fluorescence probe used to detect colorectal polyps. Link to the study: Dr. James Hardwick, Professor of gastroenterology & hepatology Research topics: Professor Hardwick’s research has contributed to many key improvements in the detection and treatment of colorectal Continue reading →

Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels

February 13, 2019 by Modulight
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Published in: Materials Science & Engineering C Authors: Kaisa Vuornos, Miina Ojansivu, Janne T. Koivisto, Heikki Häkkänen, Birhanu Belay, Toni Montonen, Heini Huhtala, Minna Kääräinen, Leena Hupa, Minna Kellomäki, Jari Hyttinen, Janne A. Ihalainen, Susanna Miettinen    Published in: Materials Science & Engineering C Authors: Kaisa Vuornos, Miina Ojansivu, Janne T. Koivisto, Heikki Häkkänen, Birhanu Belay, Toni Montonen, Heini Huhtala, Minna Kääräinen, Leena Hupa, Minna Kellomäki, Jari Hyttinen, Janne A. Ihalainen, Susanna Miettinen   Laser was used as a light source for in-house-built Selective Plane Illumination Microscopy (SPIM) multimodal system for fluorescence imaging to study activation process of stem cell osteogenesis in hydrogels for bone constructs.   Read the article here