Tag Archives: ex vivo

Photothermal therapy with platinum nanoparticles

August 16, 2021 by Modulight Content
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Photothermal therapy efficiency Human ovarian cancer cells were plated on Petri dishes and incubated with platinum nanoparticles of varying sizes between 30 and 70 nm. After 24-hour incubation, irradiation was performed using a Modulight ML6600 laser at 808 nm together with an illumination kit (MLAKIT) tailored for Petri dish illumination. A small area of the dish was illuminated with the laser for five minutes with 45 W/cm2 irradiance. Calcein cell viability staining was performed 24 hours after the laser treatment and cells were examined with a Continue reading →Customer case Experimental Biophysics and Optical Manipulation research group studies biophysical properties of the cells using advanced optical techniques like optical trapping and nanoscale thermoplasmonics. Biophysical studies include the dynamics of plasma membrane, the effect of proteins on the membrane mechanisms of plasma membrane ruptures. Another important research area is photothermal therapy (PTT) using near-infrared laser to heat metallic nanoparticles. This heating of nanoparticles is also studied to deliver RNA therapeutics into the tumor tissue.  PET imaging is used to monitor treatment effects. Modulight products: ML6600 Continue reading →

Selective laser vaporization of polypropylene mesh in tissue

June 22, 2021 by Modulight Content
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  Motivation for the study Surgical mesh is used to treat female stress urinary incontinence (SUI) and transvaginal pelvic organ prolapse (POP). However, erosion of this synthetic, non-absorbable mesh is a common complication and in more than half of these cases, a surgical excision of the mesh in the operating room is required. The mesh removal is technically challenging, may damage healthy adjacent tissues, and in some cases must be repeated several times. This study aims to explore the feasibility of selective laser vaporization, which Continue reading →Customer case University of North Carolina at Charlotte is a public research university founded in 1946. Department of Physics and Optical Science is dedicated on developing minimally invasive optics solutions for biomedical indications, such as tissue ablation, nerve simulation and surgical applications. Collaborations with Carolinas Medical Center at Charlotte and John Hopkins University at Maryland. Most recent research activities have focused on development of thulium fiber laser (TFL) as an alternative to the gold standard Holmium: YAG laser for lithotripsy (destruction of kidney stones), and Continue reading →

Effects and side-effects of plasmonic photothermal therapy in brain tissue

February 18, 2019 by Modulight
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Published in: Cancer Nanotechnology Authors: Yue He, Kristoffer Laugesen, Dana Kamp, Salik Ahmad Sultan, Lene Broeng Oddershede, Liselotte Jauffred    Published in: Cancer Nanotechnology Authors: Yue He, Kristoffer Laugesen, Dana Kamp, Salik Ahmad Sultan, Lene Broeng Oddershede, Liselotte Jauffred   Laser was used for plasmonic photothermal therapy (PPTT) studies using gold nanoshells in brain tissue phantom and different porcine cerebral tissues. The electromagnetic field of a laser beam resonates with the plasmonic field of the nanoparticles, which absorb the incident light. The absorbed energy is dissipated as heat and causes hyperthermia in tumor.   Read the article here