Tag Archives: endoscopy

Modulight Spotlights: LASER-SHARP RESEARCH – August 2024

August 7, 2024 by Modulight Content
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                    Modulight Spotlights: LASER-SHARP RESEARCH – August 2024 This month’s research highlight goes to Hirofumi Hanaoka and the team at Kansai Medical University, Japan. They developed a new laser fiber and method for illumination of narrow cavities, such as esophagus. With typical laser fibers, it is difficult to precisely illuminate target tumor in a narrow space at an oblique angle, since there is not enough space for fiber bending. The new lateral (side) emitting laser fiber was developed and evaluated for near-infrared photoimmunotherapy, which combines light, Continue reading →

Fluorescence endoscopy

June 23, 2023 by Modulight
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Fluorescence endoscopyFluorescence endoscopy is the latest advancement in endoscopy technology, which uses specialized dyes to highlight specific areas of interest and provide better visibility and image quality during procedures. This technology has revolutionized the way we view the inside of the body, enabling doctors to obtain more detailed images of the gastrointestinal tract, lungs, bladder, and reproductive organs.Endoscopy Endoscopy is a powerful tool in diagnosing and treating a wide range of medical conditions. With its minimally invasive approach and high accuracy, it has become a Continue reading →

Laser platform and light delivery optimization for bladder cancer treatment with a novel photosensitive drug

March 14, 2023 by Modulight Content
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Presented in: SPIE BIOS 2023 Authors: Zoe Ylöniemi, Elias Kokko, Visa Kaivosoja, Ana Colucci, Eerika Suokas, Jukka-Pekka Alanko, Petteri Uusimaa, Modulight Corp.    Presented in: SPIE BIOS 2023 Authors: Zoe Ylöniemi, Elias Kokko, Visa Kaivosoja, Ana Colucci, Eerika Suokas, Jukka-Pekka Alanko, Petteri Uusimaa, Modulight Corp.   Non-muscle invasive bladder cancer (NMIBC) is a form of cancer with a relatively high 5-year survival rate but also very high recurrence rate. Photodynamic diagnosis is commonly used in standard clinical practice to visualize bladder cancer lesions as part of a TURBT procedure but photodynamic treatments utilizing photosensitive drugs have had limited success in clinical setting partly because of limitations in light Continue reading →

Fluorescence imaging & endoscopy for tumor visualization and diagnostics

July 6, 2022 by Modulight Content
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Several fluorescent agents have been approved for fluorescence based diagnosis & intraoperative imaging: Dye generic name Countries Excitation Detection Indications Indocyanine Green (ICG) Worldwide 800 nm Near-infrared (820 nm) Multiple uses: lymphatic mapping, tissue perfusion, visualization of biliary ducts and blood veins, retinal angiography Fluorescein Worldwide 490 nm Green fluorescence (525 nm) Fluorescein angiography or angioscopy (ophthalmology) Methylene Blue Worldwide 665 nm 688 nm Endoscopic polypectomy, chromoendoscopy, lymphatic drainage 5-ALA Hydrochloride (converted to Pp-IX) Worldwide 400 – 410 nm Red fluorescence (620 – 710 nm) Continue reading →Introduction to fluorescence imaging Fluorescence is a phenomenon where substance that has absorbed certain wavelength of light emits it back at another wavelength. These substances are called fluorophores or fluorescent dyes. The emitted light has a longer wavelength than the absorbed one since some energy of the photon is lost in the process. The difference in wavelengths between absorbed and emitted light, called Stokes shift, allows very low background for fluorescence detection by separating it from the excitation light. The process of fluorescence generation is Continue reading →

Configurable multi-wavelength laser light engine for endoscopic fluorescence imaging

March 3, 2022 by Modulight Content
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Presented in: SPIE BIOS 2022 Authors: Zoe Ylöniemi, Visa Kaivosoja, Lasse Orsila, Tero Vierimaa, Petteri Uusimaa, Modulight Corporation (Finland)    Presented in: SPIE BIOS 2022 Authors: Zoe Ylöniemi, Visa Kaivosoja, Lasse Orsila, Tero Vierimaa, Petteri Uusimaa, Modulight Corporation (Finland)   Using different fluorescent dyes for clinical applications need endoscopic illumination sources with multiple wavelengths. Fluorescent imaging with simultaneous white light overlay image benefit from laser light sources for fluorescence excitation and white light illumination to allow for easy spectral filtering on imaging side. Imaging of complementary fluorescent dyes adds requirements for the light source. Modulight ML7710 oncology laser platform was developed to fulfill the requirements Continue reading →